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Impact of archived M184V/I mutation on the effectiveness of switch to co-formulated elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide among virally suppressed people living with HIV

Chen, Guan-Jhou ; Lee, Yu-Lin ; Lee, Chen-Hsiang ; [et al.]

Oxford University Press (OUP) ; 2020

In: Journal of Antimicrobial Chemotherapy Vol. 75, No. 10 ( 2020-10-01), p. 2986-2993

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In: Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 75, No. 10 ( 2020-10-01), p. 2986-2993

Abstract: Real-world experience regarding the effectiveness of co-formulated elvitegravir, cobicistat, emtricitabine and tenofovir alafenamide (EVG/C/FTC/TAF) as a switch regimen is sparse among people living with HIV (PLWH) harbouring the M184V/I mutation with or without thymidine analogue-associated mutations (TAMs). Methods In this retrospective multicentre study, PLWH who were switched to EVG/C/FTC/TAF after having achieved viral suppression (plasma HIV RNA & lt;200 copies/mL) for 6 months or longer were included. Patients with archived M184V/I mutation (case patients) were matched to controls without M184V/I mutation at a 1:4 ratio. Patients with a history of virological failure or resistance to elvitegravir were excluded. The primary endpoint was virological non-success (plasma HIV RNA ≥50 copies/mL) at Week 48 of switch using a modified FDA snapshot analysis. Results Overall, 100 case patients with the M184V/I mutation were identified, including 6 (6.0%) with K65R and 13 (13.0%) with at least one TAM, and were matched to 400 controls in terms of gender, age (mean = 40.3 versus 39.7 years) and cumulative exposure duration to tenofovir disoproxil fumarate (median = 146 versus 143 weeks). At Week 48, the rate of virological non-success for the case patients and controls was 5.0% (5/100) and 3.3% (13/400), respectively (difference = 1.7%; 95% CI = −2.9%–6.3%), while the rate of virological success was 88.0% and 89.5% for the case patients and controls, respectively. The presence of the K65R mutation or TAMs was not associated with virological non-response. Conclusions Among virally suppressed PLWH, EVG/C/FTC/TAF is effective in maintaining viral suppression at Week 48 despite archived M184V/I mutation with or without TAMs.

Type of Medium: Online Resource

ISSN: 0305-7453 , 1460-2091

URL: Article

DOI: 10.1093/jac/dkaa287

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2020

detail.hit.zdb_id: 1467478-6

SSG: 15,3

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Less Severe but Prolonged Course of Acute Hepatitis A in Human Immunodeficiency Virus (HIV)–Infected Patients Compared With HIV-Uninfected Patients During an Outbreak: A Multicenter Observational Study

Lee, Yu-Lin ; Chen, Guan-Jhou ; Chen, Nan-Yu ; [et al.]

Oxford University Press (OUP) ; 2018

In: Clinical Infectious Diseases Vol. 67, No. 10 ( 2018-10-30), p. 1595-1602

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In: Clinical Infectious Diseases, Oxford University Press (OUP), Vol. 67, No. 10 ( 2018-10-30), p. 1595-1602

Type of Medium: Online Resource

ISSN: 1058-4838 , 1537-6591

URL: Article

DOI: 10.1093/cid/ciy328

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Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2018

detail.hit.zdb_id: 2002229-3

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Abstracts from the 8th International Congress of the Asia Pacific Society of Infection Control (APSIC) : Bangkok, Thailand. 12-15 February 2017

Sutthiruk, Nantanit ; Botti, Mari ; Considine, Julie ; [et al.]

Springer Science and Business Media LLC ; 2017

In: Antimicrobial Resistance & Infection Control Vol. 6, No. S2 ( 2017-2)

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In: Antimicrobial Resistance & Infection Control, Springer Science and Business Media LLC, Vol. 6, No. S2 ( 2017-2)

Type of Medium: Online Resource

ISSN: 2047-2994

URL: Article

DOI: 10.1186/s13756-017-0176-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2017

detail.hit.zdb_id: 2666706-X

SSG: 15,3

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Screening for Cryptococcal Antigenemia and Burden of Cryptococcosis at the Time of HIV Diagnosis: A Retrospective Multicenter Study

Huang, Sung-Hsi ; Lee, Chun-Yuan ; Tsai, Chin-Shiang ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Infectious Diseases and Therapy Vol. 10, No. 3 ( 2021-09), p. 1363-1377

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In: Infectious Diseases and Therapy, Springer Science and Business Media LLC, Vol. 10, No. 3 ( 2021-09), p. 1363-1377

Type of Medium: Online Resource

ISSN: 2193-8229 , 2193-6382

URL: Article

DOI: 10.1007/s40121-021-00451-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2701611-0

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Care cascade of tuberculosis infection treatment for people living with HIV in the era of antiretroviral therapy scale-up

Lin, Kuan-Yin ; Yang, Chia-Jui ; Sun, Hsin-Yun ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Scientific Reports Vol. 12, No. 1 ( 2022-09-27)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 12, No. 1 ( 2022-09-27)

Abstract: Testing and treatment of tuberculosis infection (TBI) are recommended for people living with HIV (PLWH). We aimed to evaluate the care cascade of TBI treatment among PLWH in the era of antiretroviral therapy (ART) scale-up. This retrospective study included adult PLWH undergoing interferon-gamma release assay (IGRA)-based TBI screening during 2019–2021. PLWH testing IGRA-positive were advised to receive directly-observed therapy for TBI after active TB disease was excluded. The care cascade was evaluated to identify barriers to TBI management. Among 7951 PLWH with a median age of 38 years and CD4 count of 616 cells/mm 3 , 420 (5.3%) tested positive and 38 (0.5%) indeterminate for IGRA. The TBI treatment initiation rate was 73.6% (309/420) and the completion rate was 91.9% (284/309). More than 80% of PLWH concurrently received short-course rifapentine-based regimens and integrase strand transfer inhibitor (InSTI)-containing ART. The main barrier to treatment initiation was physicians’ concerns and patients’ refusal (85.6%). The factors associated with treatment non-completion were older age, female, anti-HCV positivity, and higher plasma HIV RNA. Our observation of a high TBI completion rate among PLWH is mainly related to the introduction of short-course rifapentine-based regimens in the InSTI era, which can be the strategy to improve TBI treatment uptake.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-022-20394-2

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2615211-3

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Evolution of hepatitis A virus seroprevalence among HIV-positive adults in Taiwan

Lee, Yu-Lin ; Lin, Kuan-Yin ; Cheng, Chien-Yu ; [et al.]

Public Library of Science (PLoS) ; 2017

In: PLOS ONE Vol. 12, No. 10 ( 2017-10-16), p. e0186338-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 12, No. 10 ( 2017-10-16), p. e0186338-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0186338

DOI: 10.1371/journal.pone.0186338.g001

DOI: 10.1371/journal.pone.0186338.g002

DOI: 10.1371/journal.pone.0186338.g003

DOI: 10.1371/journal.pone.0186338.t001

DOI: 10.1371/journal.pone.0186338.t002

DOI: 10.1371/journal.pone.0186338.t003

DOI: 10.1371/journal.pone.0186338.s001

DOI: 10.1371/journal.pone.0186338.s002

DOI: 10.1371/journal.pone.0186338.s003

DOI: 10.1371/journal.pone.0186338.s004

DOI: 10.1371/journal.pone.0186338.s005

DOI: 10.1371/journal.pone.0186338.s006

DOI: 10.1371/journal.pone.0186338.s007

DOI: 10.1371/journal.pone.0186338.s008

DOI: 10.1371/journal.pone.0186338.s009

DOI: 10.1371/journal.pone.0186338.s010

DOI: 10.1371/journal.pone.0186338.s011

DOI: 10.1371/journal.pone.0186338.s012

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2017

detail.hit.zdb_id: 2267670-3

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Nationwide surveillance of antimicrobial resistance in invasive isolates of Streptococcus pneumoniae in Taiwan from 2017 to 2019

Tsai, Yu-Te ; Lee, Yu-Lin ; Lu, Min-Chi ; [et al.]

Elsevier BV ; 2022

In: Journal of Microbiology, Immunology and Infection Vol. 55, No. 2 ( 2022-04), p. 215-224

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In: Journal of Microbiology, Immunology and Infection, Elsevier BV, Vol. 55, No. 2 ( 2022-04), p. 215-224

Type of Medium: Online Resource

ISSN: 1684-1182

URL: Article

DOI: 10.1016/j.jmii.2021.05.008

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2175858-X

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A 0.13 〈formula formulatype="inline"〉〈tex Notation="TeX"〉$\mu$〈/tex〉 〈/formula〉〈emphasis emphasistype="roman"〉m〈/emphasis〉 CMOS Quad-Band GSM/GPRS/EDGE RF Transceiver Using a Low-Noise Fractional-N Frequency Synthesizer and Direct-Conversion Architecture

Pei-Wei Chen ; Tser-Yu Lin ; Ling-Wei Ke ; [et al.]

Institute of Electrical and Electronics Engineers (IEEE) ; 2009

In: IEEE Journal of Solid-State Circuits Vol. 44, No. 5 ( 2009-5), p. 1454-1463

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In: IEEE Journal of Solid-State Circuits, Institute of Electrical and Electronics Engineers (IEEE), Vol. 44, No. 5 ( 2009-5), p. 1454-1463

Type of Medium: Online Resource

ISSN: 0018-9200 , 1558-173X

URL: Article

DOI: 10.1109/JSSC.2009.2015797

Language: Unknown

Publisher: Institute of Electrical and Electronics Engineers (IEEE)

Publication Date: 2009

detail.hit.zdb_id: 240580-5

detail.hit.zdb_id: 2040287-9

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Rapid establishment of a COVID-19 biobank in NHRI by National Biobank Consortium of Taiwan

Huang, Shiu-Feng ; Huang, Yhu-Chering ; Chang, Feng-Yee ; [et al.]

Elsevier BV ; 2020

In: Biomedical Journal Vol. 43, No. 4 ( 2020-08), p. 314-317

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In: Biomedical Journal, Elsevier BV, Vol. 43, No. 4 ( 2020-08), p. 314-317

Type of Medium: Online Resource

ISSN: 2319-4170

URL: Article

DOI: 10.1016/j.bj.2020.05.018

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2698541-X

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31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two : National Harbor, MD, USA. 9-13 November 2016

Ager, Casey ; Reilley, Matthew ; Nicholas, Courtney ; [et al.]

BMJ ; 2016

In: Journal for ImmunoTherapy of Cancer Vol. 4, No. S1 ( 2016-11)

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In: Journal for ImmunoTherapy of Cancer, BMJ, Vol. 4, No. S1 ( 2016-11)

Type of Medium: Online Resource

ISSN: 2051-1426

URL: Article

DOI: 10.1186/s40425-016-0173-6

Language: English

Publisher: BMJ

Publication Date: 2016

detail.hit.zdb_id: 2719863-7

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