In:
Cancer Medicine, Wiley, Vol. 7, No. 7 ( 2018-07), p. 3278-3291
Abstract:
Lymph node metastasis is an important prognosis factor in non‐small cell lung cancer ( NSCLC ) patients. The aim of this study was to investigate the role of epithelial to mesenchymal transition ( EMT ) in lymph node progression in the early stages of NSCLC . We studied a retrospective cohort of 160 consecutive surgically treated NSCLC patients with available frozen tumor samples for expression of EMT markers ( CDH 1, CTNNB 1, CDH 2, and VIMENTIN ), inducers ( TGFB 1, c‐ MET , and CAIX ), and transcription factors ( EMT ‐ TF : SNAI 1, SNAI 2, ZEB 1, TWIST 1, and TWIST 2 ). Partial EMT was more frequent in N1‐2 (N+) vs N0 patients ( P 〈 .01). TGFB 1 ( P = .02) as well as SNAI 2 ( P 〈 .01) and TWIST 1 ( P = .04) were the most differentially expressed genes in N+ tumors. In this group, ZEB 1 was correlated with all EMT inducers and other EMT ‐ TF s were overexpressed depending on the inducers. CAIX was an independent prognostic factor for overall survival ( IC 95% HR : 1.10‐5.14, P = .03). Partial EMT is involved in lymph node progression of NSCLC patients and depends on the TGF β pathway. EMT ‐ TF s are differentially expressed depending on EMT inducers. CAIX might be a relevant prognostic marker in early stage NSCLC .
Type of Medium:
Online Resource
ISSN:
2045-7634
,
2045-7634
DOI:
10.1002/cam4.2018.7.issue-7
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2659751-2
Bookmarklink
