In:
Pediatric Pulmonology, Wiley, Vol. 46, No. 3 ( 2011-03), p. 246-252
Abstract:
During the winter outbreak of 2009 influenza A (H1N1) infection in China, the number of confirmed cases and the fatal cases has grown rapidly. We describe the clinical characteristics of hospitalized children with 2009 influenza A (H1N1) infection in Shenzhen, China, November–December 2009. Methods Using a standardized form, we collected data on 148 hospitalized children. 2009 influenza A (H1N1) infection was confirmed in nasopharyngeal swab specimens with the use of a real‐time reverse transcriptase‐polymerase chain reaction assay. Results Of the 148 hospitalized children with 2009 influenza A (H1N1) infection, 81 (55%) were 5 years of age or older and 85% of the patients were previously healthy. The common presenting symptoms were fever (94%), cough (89%), runny nose (36.5%), vomiting (24%), sore throat (19.6%), wheezing (18%), abdominal pain (16%), mental status changes (9%), seizures (6%), diarrhea (6%), myalgia (6%), and chest pain (4%). Twenty‐nine (20%) patients were admitted to an ICU, 10 (7%) patients required mechanical ventilation. The overall complication rate was 65.5%, they were pneumonia in 94 (64%), neurologic complications in 18 (12%), parapneumonic effusion in 12 (8%) and myocarditis in 7 (5%). One hundred seven (72%) patients received oseltamivir treatment, 34 (23%) received within 48 hr after the onset of symptoms. All patients received antibiotics before admission or on admission. One hundred forty‐four (97%) patients were discharged; four (3%) previously healthy patients died, three died from severe encephalopathy, one died from secondary fungal meningitis. Conclusion Hospitalized children with 2009 influenza A (H1N1) infection can have a wide range of presentation and clinical complications including neurologic complications. The severe cases and deaths concentrate in previously healthy older children. Pediatr Pulmonol. 2011; 46:246–252. © 2011 Wiley‐Liss, Inc.
Type of Medium:
Online Resource
ISSN:
8755-6863
,
1099-0496
Language:
English
Publisher:
Wiley
Publication Date:
2011
detail.hit.zdb_id:
1491904-7
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