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Effect of synchronous irrigation on cyclic fatigue of nickel-titanium instrument in the dynamic and static models

Liu, Haiyun ; Li, Yanfeng ; Chai, Guangquan ; [et al.]

SAGE Publications ; 2021

In: Journal of Applied Biomaterials & Functional Materials Vol. 19 ( 2021-01)

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In: Journal of Applied Biomaterials & Functional Materials, SAGE Publications, Vol. 19 ( 2021-01)

Abstract: To evaluate the effect of synchronous water irrigation on the fatigue resistance of nickel-titanium instrument. Methods: A standardized cyclic fatigue test models were established, and five types of nickel-titanium instruments (PTU F1, WO, WOG, RE, and M3) were applied. Each instrument was randomly divided into two groups ( N = 12). There was synchronous water irrigation in the experimental group, and no water irrigation in the control group. Besides, ProTaper Universal F1 was randomly divided into 10 groups ( N = 20). In the static group, nickel-titanium instruments were divided into one control group (no irrigation, N = 20) and six experimental group (irrigation, N = 20) based on different flow rate, angle and position; while in the dynamic group, instruments were divided into one control group (no irrigation, N = 20) and two experimental group (irrigation, N = 20) based on different flow rate. The rotation time (Time to Failure, TtF) of instruments was recorded and analyzed. Results: According to the static experiments, the TtF of instruments in all experimental groups was significantly higher than that in the static control group. Besides, the dynamic tests of PTU F1 showed that the TtF in the experimental group was significantly higher than that in the dynamic control group. Compared with control group, the TtF in the experimental groups increased by at least about 30% and up to 160%. The static and dynamic tests of PTU F1 showed that the TtF of nickel-titanium instrument in all experimental groups was significantly higher than that in the control group. However, there was no significant difference between any two experimental groups. Conclusion: Regardless of dynamic or static model, TtF with irrigation was longer than that with non-irrigation, indicating that synchronous irrigation can increase the fatigue resistance of nickel-titanium instrument. However, different irrigation conditions may have the same effect on the fatigue resistance.

Type of Medium: Online Resource

ISSN: 2280-8000 , 2280-8000

URL: Article

DOI: 10.1177/2280800020987403

Language: English

Publisher: SAGE Publications

Publication Date: 2021

detail.hit.zdb_id: 2673624-X

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2

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Prognostic significance of sphingosine kinase 2 expression in non-small cell lung cancer

Wang, Qiushi ; Li, Jingyuan ; Li, Guanghua ; [et al.]

Springer Science and Business Media LLC ; 2014

In: Tumor Biology Vol. 35, No. 1 ( 2014-1), p. 363-368

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In: Tumor Biology, Springer Science and Business Media LLC, Vol. 35, No. 1 ( 2014-1), p. 363-368

Type of Medium: Online Resource

ISSN: 1010-4283 , 1423-0380

URL: Article

DOI: 10.1007/s13277-013-1051-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2014

detail.hit.zdb_id: 605825-5

detail.hit.zdb_id: 1483579-4

SSG: 12

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3

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Quantitative proteomics insights into gel properties changes of myofibrillar protein from Procambarus clarkii under cold stress

Li, Xuehong ; Li, Shugang ; Shi, Gangpeng ; [et al.]

Elsevier BV ; 2022

In: Food Chemistry Vol. 372 ( 2022-03), p. 130935-

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In: Food Chemistry, Elsevier BV, Vol. 372 ( 2022-03), p. 130935-

Type of Medium: Online Resource

ISSN: 0308-8146

URL: Article

DOI: 10.1016/j.foodchem.2021.130935

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 1483647-6

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MiR-361-3p regulates ERK1/2-induced EMT via DUSP2 mRNA degradation in pancreatic ductal adenocarcinoma

Hu, Jisheng ; Li, Le ; Chen, Hongze ; [et al.]

Springer Science and Business Media LLC ; 2018

In: Cell Death & Disease Vol. 9, No. 8 ( 2018-07-24)

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In: Cell Death & Disease, Springer Science and Business Media LLC, Vol. 9, No. 8 ( 2018-07-24)

Abstract: Metastasis remains one of the most intractable challenges in pancreatic ductal adenocarcinoma (PDAC) biology, and epithelial-to-mesenchymal transition (EMT) is essential to the epithelium-originated solid tumor metastasis cascade. Emerging evidence demonstrates that aberrant miRNA expression is involved in pancreatic cancer progression. We found that miR-361-3p was associated with an advanced stage of PDAC and poor prognosis. Hence, the effect of miR-361-3p on metastasis of PDAC cells was evaluated using Transwell assay and wound healing assay in vitro as well as orthotopic and liver metastasis pancreatic cancer models in vivo. Overexpression of miR-361-3p promoted pancreatic cancer cell migration and invasion in vitro, and miR-361-3p-elevated PDAC cells were prone to generating metastatic nodules in vivo. However, miR-361-3p showed no significant effect on the proliferation of PDAC cells in vivo or in vitro. Further study demonstrated that miR-361-3p could enhance EMT and ERK pathway activation, and ERK inhibitor could attenuate miR-361-3p-induced EMT. Luciferase assays, qPCR, and western blot and Ago2 co-immunoprecipitation were performed to identify the direct target of miR-361-3p. Mechanistic investigations identified DUSP2 as a direct target of miR-361-3p, and DUSP2 was revealed to be involved in miR-361-3p-induced EMT by directly leading to the inactivation of the ERK pathway. Moreover, we found that miR-361-3p-induced EMT was dependent on Ago2, the core component of RNA-induced silencing complex, while enforced expression of Ago2 enhanced the miR-361-3p-induced effect by promoting interference efficacy and specificity rather than regulating miR-361-3p stability and biogenesis. Thus, this study revealed that miR-361-3p functions as an oncomiR for promoting metastasis and identified the miR-361-3p/DUSP2/ERK axis as a novel EMT axis dependent on Ago2 in PDAC.

Type of Medium: Online Resource

ISSN: 2041-4889

URL: Article

DOI: 10.1038/s41419-018-0839-8

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2018

detail.hit.zdb_id: 2541626-1

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Effect of microstructure and chemical proximate composition on mechanical properties of Procambarus clarkii shell

Wang, Chao ; Shi, Gangpeng ; Que, Feng ; [et al.]

Elsevier BV ; 2022

In: LWT Vol. 165 ( 2022-08), p. 113731-

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In: LWT, Elsevier BV, Vol. 165 ( 2022-08), p. 113731-

Type of Medium: Online Resource

ISSN: 0023-6438

URL: Article

DOI: 10.1016/j.lwt.2022.113731

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 1469139-5

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Biological role of GITR/GITRL in attributes and immune responses of macrophage

Fu, Zhuo ; Wang, Shuang ; Li, Jinhua ; [et al.]

Oxford University Press (OUP) ; 2020

In: Journal of Leukocyte Biology Vol. 107, No. 2 ( 2020-02-01), p. 309-321

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In: Journal of Leukocyte Biology, Oxford University Press (OUP), Vol. 107, No. 2 ( 2020-02-01), p. 309-321

Abstract: Glucocorticoid-induced tumor necrosis factor receptor family-related protein ligand (GITRL), a member of the tumor necrosis factor superfamily, is expressed in APCs and acts as a costimulatory molecule in the immune system. Although the glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR)/GITRL system has been modulated to promote or decrease T cell-related responses in multiple diseases, studies in macrophages are limited. To address this issue, we compared the expression of GITRL in various types of macrophages and analyzed whether GITRL can affect the fundamental properties and major functions of these cells. Our results demonstrated that M1 polarized macrophages had the highest GITRL levels. Furthermore, GITRL overexpression skewed macrophage polarization toward the M1 phenotype, accelerating proliferation and migration and regulating phagocytosis and killing function. Moreover, GITRL-silenced cells showed a loss of these functions, further confirming its vital role. We also developed an acute peritonitis mouse model, in which macrophages were driven to differentiate into a proinflammatory phenotype with GITRL up-regulation, triggering a positive feedback loop. Our results provide molecular insight into how the GITR/GITRL system modulates innate immune responses, suggesting that manipulation of the GITR/GITRL system to treat diseases depends not only on T cell regulation but also on macrophage participation.

Type of Medium: Online Resource

ISSN: 1938-3673 , 0741-5400

URL: Article

DOI: 10.1002/JLB.3A0919-387RR

RVK:

XA 10000

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2020

detail.hit.zdb_id: 2026833-6

SSG: 12

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7

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Liver X receptor activation attenuates plaque formation and improves vasomotor function of the aortic artery in atherosclerotic ApoE−/− mice

Chen, Jianghong ; Zhao, Li ; Sun, Dongdong ; [et al.]

Springer Science and Business Media LLC ; 2012

In: Inflammation Research Vol. 61, No. 12 ( 2012-12), p. 1299-1307

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In: Inflammation Research, Springer Science and Business Media LLC, Vol. 61, No. 12 ( 2012-12), p. 1299-1307

Type of Medium: Online Resource

ISSN: 1023-3830 , 1420-908X

URL: Article

DOI: 10.1007/s00011-012-0529-4

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2012

detail.hit.zdb_id: 1459194-7

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8

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DataSheet1.docx

Kong, Lingrong ; Li, Shaojun ; Zhao, Zhenhua ; [et al.]

Frontiers Media SA ; 2021

In: Frontiers in Genetics Vol. 12 ( 2021-12-14)

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In: Frontiers in Genetics, Frontiers Media SA, Vol. 12 ( 2021-12-14)

Abstract: Noninvasive prenatal diagnosis (NIPD) of single-gene disorders has recently become the focus of clinical laboratories. However, reports on the clinical application of NIPD of Duchenne muscular dystrophy (DMD) are limited. This study aimed to evaluate the detection performance of haplotype-based NIPD of DMD in a real clinical environment. Twenty-one DMD families at 7–12 weeks of gestation were prospectively recruited. DNA libraries of cell-free DNA from the pregnant and genomic DNA from family members were captured using a custom assay for the enrichment of DMD gene exons and spanning single-nucleotide polymorphisms, followed by next-generation sequencing. Parental haplotype phasing was based on family linkage analysis, and fetal genotyping was inferred using the Bayes factor through target maternal plasma sequencing. Finally, the entire experimental process was promoted in the local clinical laboratory. We recruited 13 complete families, 6 families without paternal samples, and 2 families without probands in which daughter samples were collected. Two different maternal haplotypes were constructed based on family members in all 21 pedigrees at as early as 7 gestational weeks. Among the included families, the fetal genotypes of 20 families were identified at the first blood collection, and a second blood collection was performed for another family due to low fetal concentration. The NIPD result of each family was reported within 1 week. The fetal fraction in maternal cfDNA ranged from 1.87 to 11.68%. In addition, recombination events were assessed in two fetuses. All NIPD results were concordant with the findings of invasive prenatal diagnosis (chorionic villus sampling or amniocentesis). Exon capture and haplotype-based NIPD of DMD are regularly used for DMD genetic diagnosis, carrier screening, and noninvasive prenatal diagnosis in the clinic. Our method, haplotype-based early screening for DMD fetal genotyping via cfDNA sequencing, has high feasibility and accuracy, a short turnaround time, and is inexpensive in a real clinical environment.

Type of Medium: Online Resource

ISSN: 1664-8021

URL: Article

DOI: 10.3389/fgene.2021.791856

DOI: 10.3389/fgene.2021.791856.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2021

detail.hit.zdb_id: 2606823-0

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Lnc-PFAR facilitates autophagy and exacerbates pancreatic fibrosis by reducing pre-miR-141 maturation in chronic pancreatitis

Zhang, Tao ; Zhang, Guangquan ; Yang, Wenbo ; [et al.]

Springer Science and Business Media LLC ; 2021

In: Cell Death & Disease Vol. 12, No. 11 ( 2021-10-25)

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In: Cell Death & Disease, Springer Science and Business Media LLC, Vol. 12, No. 11 ( 2021-10-25)

Abstract: Chronic pancreatitis (CP) is described as progressive inflammatory fibrosis of pancreas, accompanied with irreversible impaired endocrine and exocrine insufficiency. Pancreatic stellate cells (PSCs) are widely distributed in the stroma of the pancreas and PSCs activation has been shown as one of the leading causes for pancreatic fibrosis. Our previous study has revealed that autophagy is dramatically activated in CP tissues, which facilitates PSCs activation and pancreatic fibrosis. Long non-coding RNAs (LncRNAs) have been recognized as crucial regulators for fibrosis-related diseases. LncRNAs interact with RNA binding protein or construct competitive endogenous RNA (ceRNA) hypothesis which elicited the fibrotic processes. Until now, the effects of lncRNAs on PSCs activation and pancreatic fibrosis have not been clearly explored. In this study, a novel lncRNA named Lnc-PFAR was found highly expressed in mouse and human CP tissues. Our data revealed that Lnc-PFAR facilitates PSCs activation and pancreatic fibrosis via RB1CC1-induced autophagy. Lnc-PFAR reduces miR-141 expression by suppressing pre-miR-141 maturation, which eventually upregulates the RB1CC1 and fibrosis-related indicators expression. Meanwhile, Lnc-PFAR enhanced PSCs activation and pancreatic fibrosis through trigging autophagy. Our study interrogates a novel lncRNA-induced mechanism in promoting the development of pancreatic fibrosis, and Lnc-PFAR is suggested to be a prospective therapeutic target in clinical scenarios.

Type of Medium: Online Resource

ISSN: 2041-4889

URL: Article

DOI: 10.1038/s41419-021-04236-z

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2021

detail.hit.zdb_id: 2541626-1

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Penetration of micro/nanoplastics into biological barriers in organisms and associated health effects

Qiu, Hao ; Li, Jingjing ; Chen, Guangquan ; [et al.]

Science China Press., Co. Ltd. ; 2023

In: Chinese Science Bulletin

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In: Chinese Science Bulletin, Science China Press., Co. Ltd.

Type of Medium: Online Resource

ISSN: 0023-074X

URL: Article

DOI: 10.1360/TB-2023-0295

Language: English

Publisher: Science China Press., Co. Ltd.

Publication Date: 2023

SSG: 6,25

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Kooperativer Bibliotheksverbund

Berlin Brandenburg