In:
BioMed Research International, Hindawi Limited, Vol. 2013 ( 2013), p. 1-6
Abstract:
The purpose of this study was to determine the effect of apigenin on the pharmacokinetics of imatinib and N-desmethyl imatinib in rats. Healthy male SD rats were randomly divided into four groups: A group (the control group), B group (the long-term administration of 165 mg/kg apigenin for 15 days), C group (a single dose of 165 mg/kg apigenin), and D group (a single dose of 252 mg/kg apigenin). The serum concentrations of imatinib and N-desmethyl imatinib were measured by HPLC, and pharmacokinetic parameters were calculated using DAS 3.0 software. The parameters of AUC ( 0 - t ) , AUC ( 0 − ∞ ) , T max , V z / F , and CL z / F for imatinib in group B were different from those in group A ( P 〈 0.05 ). Besides, MRT ( 0 − t ) and MRT ( 0 − ∞ ) in groups C and D differed distinctly from those in group A as well. The parameters of AUC ( 0 - t ) and C max for N-desmethyl imatinib in group C were significantly lower than those in group A ( P 〈 0.05 ); however, compared with groups B and D, the magnitude of effect was modest. Those results indicated that apigenin in the short-term study inhibited the metabolism of imatinib and its metabolite N-desmethyl imatinib, while in the long-term study the metabolism could be accelerated.
Type of Medium:
Online Resource
ISSN:
2314-6133
,
2314-6141
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2013
detail.hit.zdb_id:
2698540-8
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