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1

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Recommendations for the diagnosis and management of childhood Prader-Willi syndrome in China

Yang-Li, Dai ; Fei-Hong, Luo ; Hui-Wen, Zhang ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Orphanet Journal of Rare Diseases Vol. 17, No. 1 ( 2022-12)

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In: Orphanet Journal of Rare Diseases, Springer Science and Business Media LLC, Vol. 17, No. 1 ( 2022-12)

Abstract: Prader-Willi syndrome (PWS) is a complex and multisystem neurobehavioral disease, which is caused by the lack of expression of paternally inherited imprinted genes on chromosome15q11.2-q13.1. The clinical manifestations of PWS vary with age. It is characterized by severe hypotonia with poor suck and feeding difficulties in the early infancy, followed by overeating in late infancy or early childhood and progressive development of morbid obesity unless the diet is externally controlled. Compared to Western PWS patients, Chinese patients have a higher ratio of deletion type. Although some rare disease networks, including PWS Cooperation Group of Rare Diseases Branch of Chinese Pediatric Society, Zhejiang Expert Group for PWS, were established recently, misdiagnosis, missed diagnosis and inappropriate intervention were usually noted in China. Therefore, there is an urgent need for an integrated multidisciplinary approach to facilitate early diagnosis and optimize management to improve quality of life, prevent complications, and prolong life expectancy. Our purpose is to evaluate the current literature and evidences on diagnosis and management of PWS in order to provide evidence-based guidelines for this disease, specially from China.

Type of Medium: Online Resource

ISSN: 1750-1172

URL: Article

DOI: 10.1186/s13023-022-02302-z

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2225857-7

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2

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Efficacy, safety, and immunogenicity of an Escherichia coli-produced Human Papillomavirus (16 and 18) L1 virus-like-particle vaccine: end-of-study analysis of a phase 3, double-blind, randomised, controlled trial

Zhao, Fang-Hui ; Wu, Ting ; Hu, Yue-Mei ; [et al.]

Elsevier BV ; 2022

In: The Lancet Infectious Diseases Vol. 22, No. 12 ( 2022-12), p. 1756-1768

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In: The Lancet Infectious Diseases, Elsevier BV, Vol. 22, No. 12 ( 2022-12), p. 1756-1768

Type of Medium: Online Resource

ISSN: 1473-3099

URL: Article

DOI: 10.1016/S1473-3099(22)00435-2

Language: English

Publisher: Elsevier BV

Publication Date: 2022

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Ulmoidol, an unusual nortriterpenoid from Eucommia ulmoides Oliv. Leaves prevents neuroinflammation by targeting the PU.1 transcriptional signaling pathway

Han, Rui ; Yuan, Tian ; Yang, Zhi ; [et al.]

Elsevier BV ; 2021

In: Bioorganic Chemistry Vol. 116 ( 2021-11), p. 105345-

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In: Bioorganic Chemistry, Elsevier BV, Vol. 116 ( 2021-11), p. 105345-

Type of Medium: Online Resource

ISSN: 0045-2068

URL: Article

DOI: 10.1016/j.bioorg.2021.105345

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 1462232-4

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4

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The use of phosphonates for constructing 3d–4f clusters at high oxidation states: synthesis and characterization of two unusual heterometallic CeMn complexes

Wang, Mei ; Yuan, Da-Qiang ; Ma, Cheng-Bing ; [et al.]

Royal Society of Chemistry (RSC) ; 2010

In: Dalton Transactions Vol. 39, No. 31 ( 2010), p. 7276-

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In: Dalton Transactions, Royal Society of Chemistry (RSC), Vol. 39, No. 31 ( 2010), p. 7276-

Type of Medium: Online Resource

ISSN: 1477-9226 , 1477-9234

URL: Article

DOI: 10.1039/c002474k

Language: English

Publisher: Royal Society of Chemistry (RSC)

Publication Date: 2010

detail.hit.zdb_id: 1472887-4

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5

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Effect of postprocedural full‐dose infusion of bivalirudin on acute stent thrombosis in patients with ST ‐elevation myocardial infarction undergoing primary percutaneous coronary intervention: Outcomes in a large real‐world population

Wang, Heyang ; Liang, Zhenyang ; Li, Yi ; [et al.]

Wiley ; 2017

In: Cardiovascular Therapeutics Vol. 35, No. 3 ( 2017-06)

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In: Cardiovascular Therapeutics, Wiley, Vol. 35, No. 3 ( 2017-06)

Abstract: This study aimed to evaluate the effect of prolonged full‐dose bivalirudin infusion in real‐world population with ST ‐elevation myocardial infarction ( STEMI ). Background Subgroup data as well as meta‐analysis from randomized clinical trials have shown the potency of postprocedural full‐dose infusion (1.75 mg/kg/h) of bivalirudin on attenuating acute stent thrombosis ( ST ) after primary percutaneous coronary intervention ( PCI ). Methods In this multicenter retrospective observational study, 2047 consecutive STEMI patients treated with bivalirudin during primary PCI were enrolled in 65 Chinese centers between July 2013 and May 2016. The primary outcome was acute ST defined as ARC definite/probable within 24 hours after the index procedure, and the secondary endpoints included total ST , major adverse cardiac or cerebral events ( MACCE , defined as death, reinfarction, stroke, and target vessel revascularization), and any bleeding at 30 days. Results Among 2047 STEMI patients, 1123 (54.9%) were treated with postprocedural bivalirudin full‐dose infusion (median 120 minutes) while the other 924 (45.1%) received low‐dose (0.25 mg/kg/h) or null postprocedural infusion. A total of three acute ST (0.3%) occurred in STEMI patients with none or low‐dose prolonged infusion of bivalirudin, but none was observed in those treated with post‐ PCI full‐dose infusion (0.3% vs 0.0%, P =.092). Outcomes on MACCE (2.1% vs 2.7%, P =.402) and total bleeding (2.1% vs 1.4%, P =.217) at 30 days showed no significant difference between the two groups, and no subacute ST was observed. Conclusion Post‐ PCI full‐dose bivalirudin infusion is safe and has a trend to protect against acute ST in STEMI patients undergoing primary PCI in real‐world settings.

Type of Medium: Online Resource

ISSN: 1755-5914 , 1755-5922

URL: Issue

URL: Article

DOI: 10.1111/cdr.2017.35.issue-3

DOI: 10.1111/1755-5922.12251

Language: English

Publisher: Wiley

Publication Date: 2017

detail.hit.zdb_id: 2417088-4

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6

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The Influence of Physical and Chemical Reactions on Water Leakage in a Multiarch Tunnel

Shi, Jian-Xun ; Li, Zhao-Hui ; He, Yong-Qiang ; [et al.]

Hindawi Limited ; 2020

In: Advances in Civil Engineering Vol. 2020 ( 2020-09-23), p. 1-8

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In: Advances in Civil Engineering, Hindawi Limited, Vol. 2020 ( 2020-09-23), p. 1-8

Abstract: In many tunnels in China, the groundwater is acidic and carbonated, causing in challenges in the prevention and control of leakages of the existing tunnels and tunnels under construction. Research on tunnel leakage and the physical and chemical effects of water due to water-rock interactions is a trending topic. In addition, there is a big difference between the waterproof and drainage of multiarch tunnels and separate tunnels. In this study, the mechanism of the interaction between the groundwater and the surrounding rock of a multiarch tunnel were analyzed. The relationship between the leakage of a multiarch tunnel and the interaction between the surrounding rocks and groundwater was determined by analyzing the interaction between the chemical components in the groundwater, rocks, and the concrete lining. A mathematical model was established based on the physical and chemical reactions in the rock surrounding the tunnel, and the RNCDX.FOR program was compiled using the simplex Monte Carlo method. The total free energy in the entire system varied significantly, and the value of objective function ( J ) reflected the trend of the system's spontaneous reaction. As J decreased, the reaction power of the system increased. The more significant the erosion of the rocks was by the groundwater, the more channels were created by the groundwater in the rock, and the more likely the water leakage was.

Type of Medium: Online Resource

ISSN: 1687-8086 , 1687-8094

URL: Article

DOI: 10.1155/2020/8830739

Language: English

Publisher: Hindawi Limited

Publication Date: 2020

detail.hit.zdb_id: 2449760-5

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7

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AIE-based super-resolution imaging probes for β-amyloid plaques in mouse brains

Wang, Ya-Long ; Fan, Cheng ; Xin, Bo ; [et al.]

Royal Society of Chemistry (RSC) ; 2018

In: Materials Chemistry Frontiers Vol. 2, No. 8 ( 2018), p. 1554-1562

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In: Materials Chemistry Frontiers, Royal Society of Chemistry (RSC), Vol. 2, No. 8 ( 2018), p. 1554-1562

Type of Medium: Online Resource

ISSN: 2052-1537

URL: Article

DOI: 10.1039/C8QM00209F

Language: English

Publisher: Royal Society of Chemistry (RSC)

Publication Date: 2018

detail.hit.zdb_id: 2867881-3

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8

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Preparation and Antioxidant Activities of Peanut (〈i〉Arachin conarachin 〈/i〉L.〈i〉) 〈/i〉Protein Peptides by Bacillus Subtilis Solid State Fermentation Method

Yu, Li Na ; Feng, Jian Xiong ; Ming, Qiang Qiang ; [et al.]

Trans Tech Publications, Ltd. ; 2014

In: Advanced Materials Research Vol. 887-888 ( 2014-2), p. 601-604

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In: Advanced Materials Research, Trans Tech Publications, Ltd., Vol. 887-888 ( 2014-2), p. 601-604

Abstract: The objective of this work is to study on preparation of peanut protein peptide by bacillus subtilis solid state fermentation method. Results indicated that soluble nitrogen concentration of protein peptide could reach 122.86mg/mL, 1, 1-diphenyl-2-picryl-hydrazyl (DPPH) and hydroxyl free radicals scavenging rates were 85.22% and 84.88%, respectively, under the following optimum conditions: nutrient salt solution of 16.3mL, bacterial suspension volume of 3.8mL, temperature of 45°C, and time of 41h. IC 50 values for scavenging of DPPH, hydroxyl and superoxide anion free radicals rates, iron and copper ion chelating rates, inhibition rate of anti-lipid peroxidation were 2.88mg/mL, 4.63mg/mL, 1.22mg/mL, 0.04mg/mL, 0.94mg/mL, 3.78mg/mL, respectively. When absorbance value of iron and molybdenum reduction capacities was 0.5, the required protein peptide concentrations were 7.28mg/mL and 1.85mg/mL, respectively.

Type of Medium: Online Resource

ISSN: 1662-8985

URL: Issue

URL: Article

DOI: 10.4028/www.scientific.net/AMR.887-888

DOI: 10.4028/www.scientific.net/AMR.887-888.601

Language: Unknown

Publisher: Trans Tech Publications, Ltd.

Publication Date: 2014

detail.hit.zdb_id: 2265002-7

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9

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Optical Nanoimaging for Block Copolymer Self-Assembly

Yan, Jie ; Zhao, Ling-Xi ; Li, Chong ; [et al.]

American Chemical Society (ACS) ; 2015

In: Journal of the American Chemical Society Vol. 137, No. 7 ( 2015-02-25), p. 2436-2439

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In: Journal of the American Chemical Society, American Chemical Society (ACS), Vol. 137, No. 7 ( 2015-02-25), p. 2436-2439

Type of Medium: Online Resource

ISSN: 0002-7863 , 1520-5126

URL: Article

DOI: 10.1021/ja512189a

RVK:

VA 1120 ; VA 1752

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2015

detail.hit.zdb_id: 1472210-0

detail.hit.zdb_id: 3155-0

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Geminal cross-coupling synthesis, ion-induced emission and lysosome imaging of cationic tetraarylethene oligoelectrolytes

Zhou, Qi-Yuan ; Xin, Bo ; Wang, Ya-Long ; [et al.]

Royal Society of Chemistry (RSC) ; 2018

In: Chemical Communications Vol. 54, No. 29 ( 2018), p. 3617-3620

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In: Chemical Communications, Royal Society of Chemistry (RSC), Vol. 54, No. 29 ( 2018), p. 3617-3620

Type of Medium: Online Resource

ISSN: 1359-7345 , 1364-548X

URL: Article

DOI: 10.1039/C8CC00533H

Language: English

Publisher: Royal Society of Chemistry (RSC)

Publication Date: 2018

detail.hit.zdb_id: 1472881-3

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Kooperativer Bibliotheksverbund

Berlin Brandenburg