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Figure 9 from: Zheng G, You M, Li X, Zhou Q, Wang Z, Wang H, Lu Q (2022) Diversity of fungi associated with Monochamus alternatus larval habitats in Bursaphelenchus xylophilus-infected Pinus massoniana and identification of two new ophiostomatalean species (Ascomycota, Ophiostomatales). MycoKeys 92: 1-25. https://doi.org/10.3897/mycokeys.92.80682

Zheng, Guiheng ; You, Minqi ; Li, Xuening ; [et al.]

Pensoft Publishers ; 2022

In: MycoKeys Vol. 92 ( 2022-08-01), p. 1-25

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In: MycoKeys, Pensoft Publishers, Vol. 92 ( 2022-08-01), p. 1-25

Abstract: Bursaphelenchus xylophilus , a pathogenic pine wood nematode (PWN), is responsible for pine wilt disease (PWD), which has caused significant economic and ecological damage worldwide, particularly in East Asia. Multiple biological factors, such as the beetle vector Monochamus , symbiotic bacteria and associated fungi, are involved in the disease infection cycle. This study isolated and identified the fungal communities of Monochamus alternatus larval galleries and pupal chambers from different instars through field investigation, morphological observation and multi-locus DNA sequence analyses in Zhejiang Province, China. A total of 255 and 454 fungal strains were isolated from M. alternatus galleries and pupal chambers infected with PWN, from the 2 nd –3 rd and 4 th –5 th instar larvae, respectively. A total of 18 species of fungi were identified, 14 species were isolated from the 2 nd –3 rd instar larval galleries and six species from the galleries and pupal chambers of the 4 th –5 th instar larvae. Amongst them were six species belonging to four genera of ophiostomatalean fungi, including two novel species, Graphilbum xianjuensis sp. nov. and Ophiostoma taizhouense sp. nov. and four known species, Ceratocystiopsis weihaiensis , Ophiostoma ips , Sporothrix zhejiangensis and S. macroconidia . The findings revealed that the fungal diversity and abundance of the 2 nd –3 rd instar larvae differed markedly from those of the 4 th –5 th instar larvae. This difference could be the result of fungal succession. This study provides a thorough understanding of the fungi associated with PWD and lays the groundwork for future research.

Type of Medium: Online Resource

ISSN: 1314-4049 , 1314-4057

URL: Article

DOI: 10.3897/mycokeys.92.80682

DOI: 10.3897/mycokeys.92.80682.figure1

DOI: 10.3897/mycokeys.92.80682.figure10

DOI: 10.3897/mycokeys.92.80682.figure11

DOI: 10.3897/mycokeys.92.80682.figure2

DOI: 10.3897/mycokeys.92.80682.figure3

DOI: 10.3897/mycokeys.92.80682.figure4

DOI: 10.3897/mycokeys.92.80682.figure5

DOI: 10.3897/mycokeys.92.80682.figure6

DOI: 10.3897/mycokeys.92.80682.figure7

DOI: 10.3897/mycokeys.92.80682.figure8

DOI: 10.3897/mycokeys.92.80682.figure9

Language: Unknown

Publisher: Pensoft Publishers

Publication Date: 2022

detail.hit.zdb_id: 2630648-7

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Pharmacokinetics of Icosapent Ethyl: An Open‐Label, Multiple Oral Dose, Parallel Design Study in Healthy Chinese Subjects

Yuan, Fei ; Li, Hui ; Yang, Mengjie ; [et al.]

Wiley ; 2023

In: Clinical Pharmacology in Drug Development Vol. 12, No. 1 ( 2023-01), p. 6-13

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In: Clinical Pharmacology in Drug Development, Wiley, Vol. 12, No. 1 ( 2023-01), p. 6-13

Abstract: Icosapent ethyl (IPE) is a high‐purity prescription form of eicosapentaenoic acid (EPA) ethyl ester that has been approved to lower triglyceride levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia. Before this study, there were no pharmacokinetics (PK) or safety data in Chinese patients after receiving IPE. The purpose of this study was to evaluate the PK of EPA in plasma and red blood cells and safety after oral administration of IPE capsules for 28 consecutive days in healthy Chinese subjects. It was a randomized, open‐label, parallel‐designed multiple‐dose, phase I study. Twenty‐four subjects were enrolled and randomly assigned to 2 groups, including 6 men and 6 women in each group. Group A received IPE 2.0 g/day (1×1 g twice daily), and group B received IPE 4.0 g/day (2×1 g twice daily) with dosing after standard meals for 28 days. During the treatment period, PK samples were collected from all subjects before the morning dose on days 1, 14, 26, and 28. Following completion of the last study drug administration in the morning on day 28, an 18‐day posttreatment PK sample collection period was followed. Twenty‐four eligible subjects were enrolled in this study, and 1 subject withdrew from the study. The main PK parameters (baseline‐corrected maximum observed plasma concentration and area under the plasma concentration–time curve during a dosing interval) of plasma total EPA, RBC EPA, and plasma unesterified EPA increased with dose. Chinese healthy subjects who took IPE capsules orally in the dose range of 2.0 to 4.0 g/day for 28 consecutive days were safe and tolerable.

Type of Medium: Online Resource

ISSN: 2160-763X , 2160-7648

URL: Issue

URL: Article

DOI: 10.1002/cpdd.v12.1

DOI: 10.1002/cpdd.1130

Language: English

Publisher: Wiley

Publication Date: 2023

detail.hit.zdb_id: 2649010-9

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Evolution under Spatially Heterogeneous Selection in Solid Tumors

Li, Guanghao ; Yang, Zuyu ; Wu, Dafei ; [et al.]

Oxford University Press (OUP) ; 2022

In: Molecular Biology and Evolution Vol. 39, No. 1 ( 2022-01-07)

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In: Molecular Biology and Evolution, Oxford University Press (OUP), Vol. 39, No. 1 ( 2022-01-07)

Abstract: Spatial genetic and phenotypic diversity within solid tumors has been well documented. Nevertheless, how this heterogeneity affects temporal dynamics of tumorigenesis has not been rigorously examined because solid tumors do not evolve as the standard population genetic model due to the spatial constraint. We therefore, propose a neutral spatial (NS) model whereby the mutation accumulation increases toward the periphery; the genealogical relationship is spatially determined and the selection efficacy is blunted (due to kin competition). In this model, neutral mutations are accrued and spatially distributed in manners different from those of advantageous mutations. Importantly, the distinctions could be blurred in the conventional model. To test the NS model, we performed a three-dimensional multiple microsampling of two hepatocellular carcinomas. Whole-genome sequencing (WGS) revealed a 2-fold increase in mutations going from the center to the periphery. The operation of natural selection can then be tested by examining the spatially determined clonal relationships and the clonal sizes. Due to limited migration, only the expansion of highly advantageous clones can sweep through a large part of the tumor to reveal the selective advantages. Hence, even multiregional sampling can only reveal a fraction of fitness differences in solid tumors. Our results suggest that the NS patterns are crucial for testing the influence of natural selection during tumorigenesis, especially for small solid tumors.

Type of Medium: Online Resource

ISSN: 0737-4038 , 1537-1719

URL: Article

DOI: 10.1093/molbev/msab335

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2022

detail.hit.zdb_id: 2024221-9

SSG: 12

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Oral enzyme-responsive nanoprobes for targeted theranostics of inflammatory bowel disease

Cao, Lin ; Duan, Dengyi ; Peng, Jing ; [et al.]

Springer Science and Business Media LLC ; 2024

In: Journal of Nanobiotechnology Vol. 22, No. 1 ( 2024-08-13)

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In: Journal of Nanobiotechnology, Springer Science and Business Media LLC, Vol. 22, No. 1 ( 2024-08-13)

Type of Medium: Online Resource

ISSN: 1477-3155

URL: Article

DOI: 10.1186/s12951-024-02749-1

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2024

detail.hit.zdb_id: 2100022-0

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The role of redox-mediated lysosomal dysfunction and therapeutic strategies

He, Xiaomeng ; Li, Xuening ; Tian, Wei ; [et al.]

Elsevier BV ; 2023

In: Biomedicine & Pharmacotherapy Vol. 165 ( 2023-09), p. 115121-

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In: Biomedicine & Pharmacotherapy, Elsevier BV, Vol. 165 ( 2023-09), p. 115121-

Type of Medium: Online Resource

ISSN: 0753-3322

URL: Article

DOI: 10.1016/j.biopha.2023.115121

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 1501510-5

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PSMA1-mediated ultrasmall gold nanoparticles facilitate tumor targeting and MR/CT/NIRF multimodal detection of early-stage prostate cancer

Wang, Jiahui ; Li, Liang ; Li, Yanbo ; [et al.]

Elsevier BV ; 2023

In: Nanomedicine: Nanotechnology, Biology and Medicine Vol. 47 ( 2023-01), p. 102617-

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In: Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier BV, Vol. 47 ( 2023-01), p. 102617-

Type of Medium: Online Resource

ISSN: 1549-9634

URL: Article

DOI: 10.1016/j.nano.2022.102617

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2183417-9

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Lipid raft-associated PI3K/Akt/SREBP1 signaling regulates coxsackievirus A16 (CA16) replication

Wu, Zhijun ; Li, Xingzhi ; Guo, Dexuan ; [et al.]

Elsevier BV ; 2021

In: Veterinary Microbiology Vol. 252 ( 2021-01), p. 108921-

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In: Veterinary Microbiology, Elsevier BV, Vol. 252 ( 2021-01), p. 108921-

Type of Medium: Online Resource

ISSN: 0378-1135

URL: Article

DOI: 10.1016/j.vetmic.2020.108921

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 1498996-7

SSG: 22

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The accessory protein ORF3 of porcine epidemic diarrhea virus inhibits cellular interleukin-6 and interleukin-8 productions by blocking the nuclear factor-κB p65 activation

Wu, Zhijun ; Cheng, Lixin ; Xu, Jiaxin ; [et al.]

Elsevier BV ; 2020

In: Veterinary Microbiology Vol. 251 ( 2020-12), p. 108892-

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In: Veterinary Microbiology, Elsevier BV, Vol. 251 ( 2020-12), p. 108892-

Type of Medium: Online Resource

ISSN: 0378-1135

URL: Article

DOI: 10.1016/j.vetmic.2020.108892

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 1498996-7

SSG: 22

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Distinct Effects of Body Mass Index and Waist/Hip Ratio on Risk of Breast Cancer by Joint Estrogen and Progestogen Receptor Status: Results from a Case-Control Study in Northern and Eastern China and Implications for Chemoprevention

Wang, Fei ; Liu, Liyuan ; Cui, Shude ; [et al.]

Oxford University Press (OUP) ; 2017

In: The Oncologist Vol. 22, No. 12 ( 2017-12-01), p. 1431-1443

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In: The Oncologist, Oxford University Press (OUP), Vol. 22, No. 12 ( 2017-12-01), p. 1431-1443

Abstract: Obesity is a consideration in the pharmacologic intervention for estrogen receptor (ER) positive (ER+) breast cancer risk. Body mass index (BMI) and waist/hip ratio (WHR) have demonstrated different effects on breast cancer risk in relation to estrogen receptor (ER) status, but the results have been inconsistent. Furthermore, the situation in Chinese women remains unclear. Materials and Methods We conducted a case-control study including 1,439 breast cancer cases in Northern and Eastern China. Both ER and progesterone receptor (PR) statuses were available for 1,316 cases. Associations between body size-related factors and breast cancer risk defined by receptor status were assessed by multiple polytomous unconditional logistic regression analysis. Results Body mass index and WHR were positively associated with overall breast cancer risk. Body mass index was positively associated with both ER+/PR positive (PR+) and ER negative (ER−)/PR negative(PR−) subtype risks, although only significantly for ER+/PR+ subtype. Waist–hip ratio was only positively correlated with ER−/PR− subtype risk, although independent of BMI. Body mass index was positively associated with risk of ER+/PR+ and ER−/PR− subtypes in premenopausal women, whereas WHR was inversely correlated with ER+/PR− and positively with ER−/PR− subtype risks. Among postmenopausal women, WHR & gt;0.85 was associated with increased risk of ER−/PR− subtype. Conclusion Both general and central obesity contribute to breast cancer risk, with different effects on specific subtypes. General obesity, indicated by BMI, is more strongly associated with ER+/PR+ subtype, especially among premenopausal women, whereas central obesity, indicated by WHR, is more specific for ER−/PR− subtype, independent of menopausal status. These results suggest that different chemoprevention strategies may be appropriate in selected individuals.

Type of Medium: Online Resource

ISSN: 1083-7159 , 1549-490X

URL: Article

DOI: 10.1634/theoncologist.2017-0148

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2017

detail.hit.zdb_id: 2023829-0

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Aminopeptidase N-targeting nanomolecule-assisted delivery of VEGF siRNA to potentiate antitumour therapy by suppressing tumour revascularization and enhancing radiation response

Li, Xue ; Li, Jiang ; Li, Chunyin ; [et al.]

Royal Society of Chemistry (RSC) ; 2021

In: Journal of Materials Chemistry B Vol. 9, No. 36 ( 2021), p. 7530-7543

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In: Journal of Materials Chemistry B, Royal Society of Chemistry (RSC), Vol. 9, No. 36 ( 2021), p. 7530-7543

Abstract: Tumour revascularization and the consequent radioresistance activated by the up-regulated angiogenic pathway after radiation exposure remain a major bottleneck for improving the tumouricidal effect of radiotherapy (RT) in hepatocellular carcinoma (HCC). Herein, we show that fabricated aminopeptidase N (ANP/CD13)-targeting Gd-hybridized gold nanomolecules (tGd–GNMs) can efficaciously suppress tumour revascularization and the consequent radioresistance, and then synergize in augmenting the RT response. Both in vitro and in vivo experiments demonstrate that the targeted delivery of vascular endothelial growth factor (VEGF) siRNA into the tumour site and the generation of an abundance of intratumourally cytotoxic reactive oxygen species (ROS) under X-ray radiation by the tGd–GNMs siRNA complex has the capability to down-regulate VEGF gene expression and strengthen the radiation response. Furthermore, the tGd–GNMs siRNA complex contributes to excellent active tumour targeting ability, remarkably enhancing tumour contrast in the fluorescence, computed tomography (CT) and magnetic resonance (MR) imaging modalities in real-time with a long imaging time window. Overall, the synthesized tGd–GNMs siRNA complex with excellent potentiation of the antitumour ability and real-time multimodal imaging ability represents a promising visualized theranostic nanoplatform for the treatment of HCC.

Type of Medium: Online Resource

ISSN: 2050-750X , 2050-7518

URL: Article

DOI: 10.1039/D1TB00990G

Language: English

Publisher: Royal Society of Chemistry (RSC)

Publication Date: 2021

detail.hit.zdb_id: 2702241-9

detail.hit.zdb_id: 2705149-3

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