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Figure 4 from: Shu J-P, Liu Z-Y, Gu Z-R, Chen L-J, Wei H-J, Zhou X-L, Yan Y-H, Wang R-J (2021) Dryopteris wulingshanensis (Dryopteridaceae), a new species from Hunan, China. PhytoKeys 185: 17-26. https://doi.org/10.3897/phytokeys.185.72019

Shu, Jiang-Ping ; Liu, Zi-Yue ; Gu, Zhi-Rong ; [et al.]

Pensoft Publishers ; 2021

In: PhytoKeys Vol. 185 ( 2021-11-10), p. 17-26

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In: PhytoKeys, Pensoft Publishers, Vol. 185 ( 2021-11-10), p. 17-26

Abstract: Dryopteris wulingshanensis , a new species growing on limestone in the Wulingshan Mountains, Hunan, China, is described and illustrated. This species is most similar to D. jishouensis and D. gymnophylla on general morphological traits, such as the form of scales, rhizome and sori, but differs by the number of vascular bundles at the base of the petiole, length to width ratio of lamina, stalk length of basal pinnae, division of the lamina, apex form of the pinnule and habitat. Moreover, molecular phylogenetic analysis using the chloroplast rbc L gene suggested that D. wulingshanensis , as the sister group of D. jishouensis , is a monophyletic clade. According to its restricted geographic range, small populations and few individuals, D. wulingshanensis should be considered endangered, according to the IUCN Red List criteria.

Type of Medium: Online Resource

ISSN: 1314-2003 , 1314-2011

URL: Article

DOI: 10.3897/phytokeys.185.72019

DOI: 10.3897/phytokeys.185.72019.figure1

DOI: 10.3897/phytokeys.185.72019.figure2

DOI: 10.3897/phytokeys.185.72019.figure3

DOI: 10.3897/phytokeys.185.72019.figure4

Language: Unknown

Publisher: Pensoft Publishers

Publication Date: 2021

detail.hit.zdb_id: 2579891-1

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DataSheet8.zip

Liu, Bu-Hui ; Tu, Yue ; Ni, Guang-Xia ; [et al.]

Frontiers Media SA ; 2021

In: Frontiers in Pharmacology Vol. 12 ( 2021-7-15)

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In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 12 ( 2021-7-15)

Abstract: Background: The total flavones of Abelmoschus manihot (TFA), a compound that is extracted from Abelmoschus manihot , has been widely used in China to reduce podocyte injury in diabetic kidney disease (DKD). However, the mechanisms underlying the therapeutic action of this compound have yet to be elucidated. Podocyte pyroptosis is characterized by activation of the NLRP3 inflammasome and plays an important role in inflammation-mediated diabetic kidneys. Regulation of the PTEN/PI3K/Akt pathway is an effective strategy for improving podocyte damage in DKD. Previous research has also shown that N6-methyladenosine (m 6 A) modification is involved in DKD and that m 6 A-modified PTEN regulates the PI3K/Akt pathway. In this study, we investigated whether TFA alleviates podocyte pyroptosis and injury by targeting m 6 A modification-mediated NLRP3-inflammasome activation and PTEN/PI3K/Akt signaling. Methods: We used MPC-5 cells under high glucose (HG) conditions to investigate the key molecules that are involved in podocyte pyroptosis and injury, including activation of the NLRP3 inflammasome and the PTEN/PI3K/Akt pathway. We detected alterations in the levels of three methyltransferases that are involved in m 6 A modification. We also investigated changes in the levels of these key molecules in podocytes with the overexpression or knockdown of methyltransferase-like (METTL)3. Results: Analysis showed that TFA and MCC950 protected podocytes against HG-induced pyroptosis and injury by reducing the protein expression levels of gasdermin D, interleukin-1β, and interleukin-18, and by increasing the protein expression levels of nephrin, ZO-1, WT1 and podocalyxin. TFA and 740Y-P inhibited activation of the NLRP3 inflammasome via the PI3K/Akt pathway by inhibiting the protein levels of NIMA-related kinase7, NLRP3, ASC, and caspase-1, and by increasing the protein expression levels of p-PI3K and p-Akt. TFA improved pyroptosis and injury in HG-stimulated podocytes by regulating METTL3-dependent m 6 A modification. Conclusion: Collectively, our data indicated that TFA could ameliorate pyroptosis and injury in podocytes under HG conditions by adjusting METTL3-dependent m 6 A modification and regulating NLRP3-inflammasome activation and PTEN/PI3K/Akt signaling. This study provides a better understanding of how TFA can protect podocytes in DKD.

Type of Medium: Online Resource

ISSN: 1663-9812

URL: Article

DOI: 10.3389/fphar.2021.667644

DOI: 10.3389/fphar.2021.667644.s001

DOI: 10.3389/fphar.2021.667644.s002

DOI: 10.3389/fphar.2021.667644.s003

DOI: 10.3389/fphar.2021.667644.s004

DOI: 10.3389/fphar.2021.667644.s005

DOI: 10.3389/fphar.2021.667644.s006

DOI: 10.3389/fphar.2021.667644.s007

DOI: 10.3389/fphar.2021.667644.s008

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2021

detail.hit.zdb_id: 2587355-6

SSG: 15,3

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Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study

Wang, Yang ; Li, Fei ; Chu, Chao ; [et al.]

Elsevier BV ; 2022

In: eClinicalMedicine Vol. 48 ( 2022-06), p. 101420-

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In: eClinicalMedicine, Elsevier BV, Vol. 48 ( 2022-06), p. 101420-

Type of Medium: Online Resource

ISSN: 2589-5370

URL: Article

DOI: 10.1016/j.eclinm.2022.101420

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2946413-4

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Data_Sheet_1.docx

Wang, Yang ; Chen, Chen ; Hu, Gui-Lin ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Cardiovascular Medicine Vol. 9 ( 2022-2-24)

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In: Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-2-24)

Abstract: Renalase, a novel secretory flavoprotein with amine oxidase activity, is secreted into the blood by the kidneys and is hypothesized to participate in blood pressure (BP) regulation. We investigated the associations of renalase with BP and the risk of hypertension by examining renalase single nucleopeptide polymorphism (SNPs), serum renalase levels, and renal expression of renalase in humans. Methods ① Subjects ( n = 514) from the original Baoji Salt-Sensitive Study cohort were genotyped to investigate the association of renalase SNPs with longitudinal BP changes and the risk of hypertension during 14 years of follow-up. ② Two thousand three hundred and ninety two participants from the Hanzhong Adolescent Hypertension Study cohort were used to examine the association of serum renalase levels with hypertension. Renalase expression in renal biopsy specimens from 193 patients were measured by immunohistochemistry. ③ Renalase expression was compared in hypertensive vs. normotensive patients. Results ① SNP rs7922058 was associated with 14-year change in systolic BP, and rs10887800, rs796945, rs1935582, rs2296545, and rs2576178 were significantly associated with 14-year change in diastolic BP while rs1935582 and rs2576178 were associated with mean arterial pressure change over 14 years. In addition, SNPs rs796945, rs1935582, and rs2576178 were significantly associated with hypertension incidence. Gene-based analysis found that renalase gene was significantly associated with hypertension incidence over 14-year follow-up after adjustment for multiple measurements. ② Hypertensive subjects had higher serum renalase levels than normotensive subjects (27.2 ± 0.4 vs. 25.1 ± 0.2 μg/mL). Serum renalase levels and BPs showed a linear correlation. In addition, serum renalase was significantly associated with the risk of hypertension [ OR = 1.018 (1.006–1.030)]. ③ The expression of renalase in human renal biopsy specimens significantly decreased in hypertensive patients compared to non-hypertensive patients (0.030 ± 0.001 vs. 0.038 ± 0.004). Conclusions These findings indicate that renalase may play an important role in BP progression and development of hypertension.

Type of Medium: Online Resource

ISSN: 2297-055X

URL: Article

DOI: 10.3389/fcvm.2022.800427

DOI: 10.3389/fcvm.2022.800427.s001

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2781496-8

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Image3.TIF

Wang, Mei-Zi ; Wang, Jie ; Cao, Dong-Wei ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Pharmacology Vol. 13 ( 2022-3-18)

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In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-3-18)

Abstract: Background: Fucoidan (FPS) has been widely used to treat renal fibrosis (RF) in patients with diabetic kidney disease (DKD); however, the precise therapeutic mechanisms remain unclear. Recently, research focusing on inflammation-derived podocyte pyroptosis in DKD has attracted increasing attention. This phenomenon is mediated by the activation of the nucleotide-binding oligomerization domain (Nod)-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, leading to RF during DKD progression. Therefore, we designed a series of experiments to investigate the ameliorative effects of FPS on RF in DKD and the mechanisms that are responsible for its effect on NLRP3 inflammasome-mediated podocyte pyroptosis in the diabetic kidney. Methods: The modified DKD rat models were subjected to uninephrectomy, intraperitoneal injection of streptozotocin, and a high-fat diet. Following induction of renal injury, the animals received either FPS, rapamycin (RAP), or a vehicle for 4 weeks. For in vitro research, we exposed murine podocytes to high glucose and MCC950, an NLRP3 inflammasome inhibitor, with or without FPS or RAP. Changes in the parameters related to RF and inflammatory podocyte injury were analyzed in vivo . Changes in podocyte pyroptosis, NLRP3 inflammasome activation, and activation of the adenosine monophosphate-activated protein kinase (AMPK)/mammalian target of rapamycin complex 1 (mTORC1)/NLRP3 signaling axis involved in these changes were analyzed in vivo and in vitro . Results: FPS and RAP ameliorated RF and inflammatory podocyte injury in the DKD model rats. Moreover, FPS and RAP attenuated podocyte pyroptosis, inhibited NLRP3 inflammasome activation, and regulated the AMPK/mTORC1/NLRP3 signaling axis in vivo and in vitro . Notably, our data showed that the regulative effects of FPS, both in vivo and in vitro , on the key signaling molecules, such as p-AMPK and p-raptor, in the AMPK/mTORC1/NLRP3 signaling axis were superior to those of RAP, but similar to those of metformin, an AMPK agonist, in vitro . Conclusion: We confirmed that FPS, similar to RAP, can alleviate RF in DKD by inhibiting NLRP3 inflammasome-mediated podocyte pyroptosis via regulation of the AMPK/mTORC1/NLRP3 signaling axis in the diabetic kidney. Our findings provide an in-depth understanding of the pathogenesis of RF, which will aid in identifying precise targets that can be used for DKD treatment.

Type of Medium: Online Resource

ISSN: 1663-9812

URL: Article

DOI: 10.3389/fphar.2022.790937

DOI: 10.3389/fphar.2022.790937.s001

DOI: 10.3389/fphar.2022.790937.s002

DOI: 10.3389/fphar.2022.790937.s003

DOI: 10.3389/fphar.2022.790937.s004

DOI: 10.3389/fphar.2022.790937.s005

DOI: 10.3389/fphar.2022.790937.s006

DOI: 10.3389/fphar.2022.790937.s007

DOI: 10.3389/fphar.2022.790937.s008

DOI: 10.3389/fphar.2022.790937.s009

DOI: 10.3389/fphar.2022.790937.s010

DOI: 10.3389/fphar.2022.790937.s011

DOI: 10.3389/fphar.2022.790937.s012

DOI: 10.3389/fphar.2022.790937.s013

DOI: 10.3389/fphar.2022.790937.s014

DOI: 10.3389/fphar.2022.790937.s015

DOI: 10.3389/fphar.2022.790937.s016

DOI: 10.3389/fphar.2022.790937.s017

DOI: 10.3389/fphar.2022.790937.s018

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2587355-6

SSG: 15,3

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Image3.TIFF

Wang, Wen-Wen ; Liu, Ying-Lu ; Wang, Mei-Zi ; [et al.]

Frontiers Media SA ; 2021

In: Frontiers in Pharmacology Vol. 12 ( 2021-8-2)

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In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 12 ( 2021-8-2)

Abstract: Background: The proximal renal tubule plays a critical role in diabetic kidney disease (DKD) progression. Early glomerular disease in DKD triggers a cascade of injuries resulting in renal tubulointerstitial disease. These pathophysiological responses are collectively described as diabetic tubulopathy (DT). Thus, therapeutic strategies targeting DT hold significant promise for early DKD treatment. Shenkang injection (SKI) has been widely used to treat renal tubulointerstitial fibrosis in patients with chronic kidney disease in China. However, it is still unknown whether SKI can alleviate DT. We designed a series of experiments to investigate the beneficial effects of SKI in DT and the mechanisms that are responsible for its effect on epithelial-to-mesenchymal transition (EMT) and endoplasmic reticulum (ER) stress-induced apoptosis in DT. Methods: The modified DKD rat models were induced by uni-nephrectomy, streptozotocin intraperitoneal injection, and a high-fat diet. Following the induction of renal injury, these animals received either SKI, rosiglitazone (ROS), or vehicle, for 42 days. For in vitro research, we exposed NRK-52E cells to high glucose (HG) and 4-phenylbutyric acid (4-PBA) with or without SKI or ROS. Changes in parameters related to renal tubular injury and EMT were analyzed in vivo. Changes in the proportion of apoptotic renal tubular cells and ER stress, and the signaling pathways involved in these changes, were analyzed both in vivo and in vitro . Results: SKI and ROS improved the general condition, the renal morphological appearance and the key biochemical parameters, and attenuated renal injury and EMT in the rat model of DKD. In addition, SKI and ROS alleviated apoptosis, inhibited ER stress, and suppressed PERK-eIF2α-ATF4-CHOP signaling pathway activation both in vivo and in vitro . Notably, our data showed that the regulatory in vitro effects of SKI on PERK-eIF2α-ATF4-CHOP signaling were similar to those of 4-PBA, a specific inhibitor of ER stress. Conclusion: This study confirmed that SKI can alleviate DT in a similar manner as ROS, and SKI achieves this effect by inhibiting EMT and ER stress-induced apoptosis. Our findings thereby provide novel information relating to the clinical value of SKI in the treatment of DT.

Type of Medium: Online Resource

ISSN: 1663-9812

URL: Article

DOI: 10.3389/fphar.2021.662706

DOI: 10.3389/fphar.2021.662706.s001

DOI: 10.3389/fphar.2021.662706.s002

DOI: 10.3389/fphar.2021.662706.s003

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2021

detail.hit.zdb_id: 2587355-6

SSG: 15,3

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Excess sarcoplasmic reticulum-mitochondria calcium transport induced by Sphingosine-1-phosphate contributes to cardiomyocyte hypertrophy

Qi, Ying ; Li, Jing-Jing ; Di, Xiao-Hui ; [et al.]

Elsevier BV ; 2021

In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research Vol. 1868, No. 5 ( 2021-04), p. 118970-

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In: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Elsevier BV, Vol. 1868, No. 5 ( 2021-04), p. 118970-

Type of Medium: Online Resource

ISSN: 0167-4889

URL: Article

DOI: 10.1016/j.bbamcr.2021.118970

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 2209512-3

SSG: 12

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Global trend analysis, mechanistic insights and future directions of autoimmune ear diseases: Based on comprehensive findings over the past 20 years

Liu, Yu-Chen ; Yang, Yi-Pin ; Han, Yan-Xun ; [et al.]

Elsevier BV ; 2024

In: Autoimmunity Reviews ( 2024-11), p. 103679-

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In: Autoimmunity Reviews, Elsevier BV, ( 2024-11), p. 103679-

Type of Medium: Online Resource

ISSN: 1568-9972

URL: Article

DOI: 10.1016/j.autrev.2024.103679

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 2099325-0

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Road dust exposure and human corneal damage in a plateau high geological background provincial capital city: Spatial distribution, sources, bioaccessibility, and cytotoxicity of dust heavy metals

Yang, Zi-Yue ; Liu, Hai ; Li, Jing-Ya ; [et al.]

Elsevier BV ; 2024

In: Science of The Total Environment Vol. 912 ( 2024-02), p. 169140-

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In: Science of The Total Environment, Elsevier BV, Vol. 912 ( 2024-02), p. 169140-

Type of Medium: Online Resource

ISSN: 0048-9697

URL: Article

DOI: 10.1016/j.scitotenv.2023.169140

RVK:

AR 10100

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 1498726-0

detail.hit.zdb_id: 121506-1

SSG: 12

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Associations of genetic variations in NEDD4L with salt sensitivity, blood pressure changes and hypertension incidence in Chinese adults

Niu, Ze‐Jiaxin ; Yao, Shi ; Zhang, Xi ; [et al.]

Wiley ; 2022

In: The Journal of Clinical Hypertension Vol. 24, No. 10 ( 2022-10), p. 1381-1389

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In: The Journal of Clinical Hypertension, Wiley, Vol. 24, No. 10 ( 2022-10), p. 1381-1389

Abstract: Neural precursor cell expressed developmentally downregulated 4‐like (NEDD4L), a member of the E3 ubiquitin‐protein ligases, encoded by NEDD4L gene, was found to be involved in in salt sensitivity by regulating sodium reabsorption in salt‐sensitive rats. The authors aimed to explore the associations of NEDD4L genetic variants with salt sensitivity, blood pressure (BP) changes and hypertension incidence in Chinese adults. Participants from 124 families in Northern China in the Baoji Salt‐Sensitive Study Cohort in 2004, who received the chronic salt intake intervention, including a 7‐day low‐salt diet (3.0 g/day) and a 7‐day high‐salt diet (18 g/day), were analyzed. Besides, the development of hypertension over 14 years was evaluated. NEDD4L single nucleotide polymorphism (SNP) rs74408486 was shown to be significantly associated with systolic BP (SBP), diastolic BP (DBP) and mean arterial pressure (MAP) responses to low‐salt diet, while SNPs rs292449 and rs2288775 were significantly associated with pulse pressure (PP) response to high‐salt diet. In addition, SNP rs4149605, rs73450471, and rs482805 were significantly associated with the longitudinal changes in SBP, DBP, MAP, or PP at 14 years of follow‐up. SNP rs292449 was significantly associated with hypertension incidence over the 14‐year follow‐up. Finally, this gene‐based analysis found that NEDD4L was significantly associated with longitudinal BP changes and the incidence of hypertension over the 14‐year follow‐up. This study indicated that gene polymorphism in NEDD4L serve an important function in salt sensitivity, longitudinal BP change and development of hypertension in the Chinese population.

Type of Medium: Online Resource

ISSN: 1524-6175 , 1751-7176

URL: Issue

URL: Article

DOI: 10.1111/jch.v24.10

DOI: 10.1111/jch.14566

Language: English

Publisher: Wiley

Publication Date: 2022

detail.hit.zdb_id: 2058690-5

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