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Studio della cistatina C (Cys C) in relazione al calcolo del filtrato glomerulare e a parametri bioimpedenziometrici in soggetti obesi affetti e non affetti da diabete tipo 2

Liani, Mario ; Trabassi, Ernesto ; Tresca, Ettore ; [et al.]

PAGEPress Publications ; 2012

In: Italian Journal of Medicine Vol. 6, No. 1 ( 2012-3), p. 33-37

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In: Italian Journal of Medicine, PAGEPress Publications, Vol. 6, No. 1 ( 2012-3), p. 33-37

Type of Medium: Online Resource

ISSN: 1877-9344

URL: Article

DOI: 10.1016/j.itjm.2011.07.012

Language: Italian

Publisher: PAGEPress Publications

Publication Date: 2012

detail.hit.zdb_id: 2515650-0

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Abstract 194: Determinants of Platelet Activation in Chronic Kidney Disease

Vazzana, Natale ; Liani, Mario ; Giacci, Luciano ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2012

In: Arteriosclerosis, Thrombosis, and Vascular Biology Vol. 32, No. suppl_1 ( 2012-05)

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In: Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 32, No. suppl_1 ( 2012-05)

Abstract: Background. Mechanisms of accelerated atherothrombosis in patients with chronic kidney disease (CKD) are only partly characterized. The aims of this study were to evaluate the extent of thromboxane (TX)-dependent platelet activation in patients with CKD, and to characterize the determinants of altered TX biosynthesis in this setting, with particular reference to enhanced lipid peroxidation and the hyperactivity of the ligand-RAGE axis. Methods. A cross sectional comparison between urinary 8-iso-PGF 2 α and 11-dehydro-TXB 2 , in vivo markers of oxidative stress and platelet activation, respectively, and plasma endogenous secretory (es)RAGE has been performed in 95 patients with CKD and 20 healthy controls. Results. Urinary 8-iso-PGF 2 α and 11-dehydro-TXB 2 were significantly higher in CKD patients as compared to healthy controls (P 〈 0.0001). A significant direct correlation has been found between urinary 8-iso-PGF 2 α and 11-dehydro-TXB 2 (Rho = 0.47, P 〈 0.0001). In CKD patients, urinary 11-dehydro-TXB 2 was inversely related with estimated glomerular filtration rate (eGFR) (Rho=-0.35, P=0.001) and hemoglobin levels (Rho = -0.53, P 〈 0.0001). In addition, plasma esRAGE levels were inversely related with eGFR (Rho=-0.30, P=0.006). On multivariate analysis, urinary 8-iso-PGF 2 α and hemoglobin levels were the only independent predictors of urinary 11-dehydro-TXB 2 levels. Discussion . This study provides biochemical evidence of persistent platelet activation in patients with CKD. This condition occurs early in the natural history of the disease and is related to kidney function and oxidative stress. Moreover, we found an independent inverse relationship between hemoglobin levels and thromboxane-dependent platelet activation. This finding may provide mechanicistic link between CKD-related anemia and increased cardiovascular risk.

Type of Medium: Online Resource

ISSN: 1079-5642 , 1524-4636

URL: Article

DOI: 10.1161/atvb.32.suppl_1.A194

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2012

detail.hit.zdb_id: 1494427-3

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Study of pulsed electrostatic field (PESF) in the perfusion of peripheral tissues: Microangiopathy, nutrition and quality of perceiver life

Liani, Rossella ; La Torre, Sara ; Liani, Valentina ; [et al.]

Public Library of Science (PLoS) ; 2022

In: PLOS ONE Vol. 17, No. 9 ( 2022-9-15), p. e0268497-

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In: PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 9 ( 2022-9-15), p. e0268497-

Abstract: Microangiopathy compromises the structural and functional integrity of organs and tissues in patients with type II diabetes mellitus (T2DM) negatively affecting the perceived quality of life. Nitric oxide (NO) is a multifunctional signalling molecule, acting as a vasodilator, neurotransmitter, and modulator of inflammatory processes. Patients with type II diabetes mellitus and chronic kidney disease, controlled from glycaemic status, were treated or not with pulsed electrostatic field (PESF) cycles to evaluate effect on the perfusion of peripheral tissues. Everyone was monitored for the metabolic profile, and we tested circulating NO with a commercial enzyme immunoassay kit. In addition, we tested the perceived quality of life of patients before/after a PESF cycle using a questionnaire. Patients treated with PESF were improved circulating NO levels, significant changes in systolic and diastolic blood pressure, heart rate and were more homogeneous for their metabolic profile. The questionnaire showed also a marked improvement in the perceived quality of life. The use of pulsed electrostatic fields has allowed us to observe an improvement in the metabolic, psychological, and clinical profile in patients with T2DM and chronic kidney disease whose pathological profile is strongly compromised.

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0268497

DOI: 10.1371/journal.pone.0268497.g001

DOI: 10.1371/journal.pone.0268497.g002

DOI: 10.1371/journal.pone.0268497.g003

DOI: 10.1371/journal.pone.0268497.t001

DOI: 10.1371/journal.pone.0268497.s001

DOI: 10.1371/journal.pone.0268497.s002

DOI: 10.1371/journal.pone.0268497.s003

DOI: 10.1371/journal.pone.0268497.r001

DOI: 10.1371/journal.pone.0268497.r002

DOI: 10.1371/journal.pone.0268497.r003

DOI: 10.1371/journal.pone.0268497.r004

DOI: 10.1371/journal.pone.0268497.r005

DOI: 10.1371/journal.pone.0268497.r006

DOI: 10.1371/journal.pone.0268497.r007

DOI: 10.1371/journal.pone.0268497.r008

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2022

detail.hit.zdb_id: 2267670-3

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Study of cystatin C (Cys C) in relation to the calculation of the glomerular filtration rate and bioelectrical impedance analysis parameters in obese patients with and without type 2 diabetes

Liani, Mario ; Trabassi, Ernesto ; Tresca, Ettore ; [et al.]

PAGEPress Publications ; 2012

In: Italian Journal of Medicine ( 2012-01-30), p. 33-37

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In: Italian Journal of Medicine, PAGEPress Publications, ( 2012-01-30), p. 33-37

Abstract: IntroductionAssessment of renal function based on quantification of the glomerular filtration rate (GFR) is essential for early detection of damage and progression of renal diseases. The purpose of our study was to determine the value of cystatin C (Cys C) assays in the calculation of the GFR and bioelectrical impedance analysis parameters in obese subjects aged 30-70 years with moderately damaged renal function.Materials and methodsCys C levels were measured with a new immunoturbidimetric kit (Roche Diagnostics) and an automated Cobas c6000 analyzer. In the GFR calculation, creatinine and Cys C levels were included. The GFR calculated with the equation that included Cys C in obese and normal-weight patients is not affected by changes in the lean body mass.ResultsObese patients (N = 70) had a mean (± SD) serum creatinine level of 1.52 ± 1.0 mg/dL and a mean Cys C level of 1.28 ± 0.59 mg/L. In this group, the GFR calculated on the basis of MDRD, Cys C, and creatinine clearance values showed similar filtered values between MDRD and Cys C and a DS value smaller in the case of Cys C. The correlation (R2) between GFR and its metabolite is higher in the case of Cys C when somatotype parameters (measured with bioelectrical impedance analysis) were introduced into the equation.ConclusionsWhen Cys C is included in calculations of GFR, the result shows a higher correlation degree compared to the MDRD system. Given that Cys C shows less intra-individual variability than creatinine, it can be applied in routine diagnostics in a larger number of patients.

Type of Medium: Online Resource

ISSN: 1877-9352 , 1877-9344

URL: Article

DOI: 10.4081/itjm.2012.33

Language: Unknown

Publisher: PAGEPress Publications

Publication Date: 2012

detail.hit.zdb_id: 2515650-0

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Effects of a pulsatile electrostatic field on ischemic injury to the diabetic foot: Evaluation of refractory ulcers

Liani, Mario ; Trabassi, Ernesto ; Cusaro, Claudio ; [et al.]

Elsevier BV ; 2014

In: Primary Care Diabetes Vol. 8, No. 3 ( 2014-10), p. 244-249

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In: Primary Care Diabetes, Elsevier BV, Vol. 8, No. 3 ( 2014-10), p. 244-249

Type of Medium: Online Resource

ISSN: 1751-9918

URL: Article

DOI: 10.1016/j.pcd.2013.11.009

Language: English

Publisher: Elsevier BV

Publication Date: 2014

detail.hit.zdb_id: 2273997-X

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In vivo thromboxane‐dependent platelet activation is persistently enhanced in subjects with impaired glucose tolerance

Santilli, Francesca ; Zaccardi, Francesco ; Liani, Rossella ; [et al.]

Wiley ; 2020

In: Diabetes/Metabolism Research and Reviews Vol. 36, No. 2 ( 2020-02)

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In: Diabetes/Metabolism Research and Reviews, Wiley, Vol. 36, No. 2 ( 2020-02)

Abstract: Impaired glucose tolerance (IGT) is associated with increased cardiovascular morbidity and mortality. Enhanced thromboxane (TX)‐dependent platelet activation plays a pivotal role in atherothrombosis and characterizes type 2 diabetes mellitus (DM). Whether this also pertains to IGT is currently unknown. We investigated whether TXA 2 ‐dependent platelet activation, as reflected by 11‐dehydro‐TXB 2 (TXM) urinary excretion, is comparably abnormal in IGT as in DM, is persistent over long‐term follow‐up, changes as a function of metabolic disease progression, and is influenced by food intake. Methods We prospectively investigated subjects with IGT (n = 48) and two control groups with DM diagnosed either less than 12 months (n = 60) or 12 months or more (n = 58). Results Baseline TXM excretion was comparable between subjects with IGT and DM, with no evidence of a circadian variation. During a 36‐month follow‐up, urinary TXM excretion was stable over time in the DM groups, while tended to increase in subjects with IGT. Increasing urinary TXM excretion over time was observed in the subjects who progressed to diabetes vs nonprogressors. Conclusions We conclude that TXA 2 ‐dependent platelet activation was at least as high in IGT as in patients with DM and further increased over time, especially in those who progressed to overt diabetes.

Type of Medium: Online Resource

ISSN: 1520-7552 , 1520-7560

URL: Issue

URL: Article

DOI: 10.1002/dmrr.v36.2

DOI: 10.1002/dmrr.3232

Language: English

Publisher: Wiley

Publication Date: 2020

detail.hit.zdb_id: 2001565-3

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Effects of atorvastatin and rosuvastatin on thromboxane-dependent platelet activation and oxidative stress in hypercholesterolemia

Puccetti, Luca ; Santilli, Francesca ; Pasqui, Anna Laura ; [et al.]

Elsevier BV ; 2011

In: Atherosclerosis Vol. 214, No. 1 ( 2011-01), p. 122-128

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In: Atherosclerosis, Elsevier BV, Vol. 214, No. 1 ( 2011-01), p. 122-128

Type of Medium: Online Resource

ISSN: 0021-9150

URL: Article

DOI: 10.1016/j.atherosclerosis.2010.10.006

Language: English

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 1499887-7

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Oxidative stress and thromboxane-dependent platelet activation in inflammatory bowel disease: effects of anti-TNF-α treatment

Guerci, Marco ; Simeone, Paola ; Ardizzone, Sandro ; [et al.]

Georg Thieme Verlag KG ; 2016

In: Thrombosis and Haemostasis Vol. 116, No. 09 ( 2016), p. 486-495

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In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 116, No. 09 ( 2016), p. 486-495

Abstract: Patients with inflammatory bowel disease (IBD) are at higher risk of venous thromboembolism and coronary artery disease despite having a lower burden of traditional risk factors. Platelets from IBD patients release more soluble CD40 ligand (CD40L), and this has been implicated in IBD platelet hyper-activation. We here measured the urinary F2-isoprostane 8-iso-prostaglandin (PG)2α (8-iso-PGF2α), urinary 11–dehydro–thromboxane (TX) B2 (11-dehydro–TXB2) and plasma CD40L in IBD patients, and explored the in vitro action of anti-tumour necrosis factor (TNF)–α antibody infliximab on IBD differentiating megakaryocytes. Urinary and blood samples were collected from 124 IBD patients and 37 healthy subjects. Thirteen IBD patients were also evaluated before and after 6–week infliximab treatment. The in vitro effect of infliximab on patient-derived megakaryocytes was evaluated by immunoflorescence microscopy and by flow cytometry. IBD patients had significantly (p 〈 0.0001) higher urinary 8–iso–PGF2α and 11–dehydro–TXB2 as well as plasma CD40L levels than controls, with active IBD patients displaying higher urinary and plasma values when compared to inactive patients in remission. A 6-week treatment with infliximab was associated with a significant reduction of the urinary excretion of 8–iso–PGF2α and 11–dehydro–TXB2 (p=0.008) and plasma CD40L (p=0.001). Infliximab induced significantly rescued pro-platelet formation by megakaryocytes derived from IBD patients but not from healthy controls. Our findings provide evidence for enhanced in vivo TX–dependent platelet activation and lipid peroxidation in IBD patients. Anti-TNF–α therapy with infliximab down-regulates in vivo isoprostane generation and TX biosynthesis in responder IBD patients. Further studies are needed to clarify the implication of infliximab induced-proplatelet formation from IBD megakaryocytes. Supplementary Material to this article is available online at www.thrombosis-online.com.

Type of Medium: Online Resource

ISSN: 0340-6245 , 2567-689X

URL: Article

DOI: 10.1160/TH16-02-0167

Language: English

Publisher: Georg Thieme Verlag KG

Publication Date: 2016

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Plasma levels of soluble CD36, platelet activation, inflammation, and oxidative stress are increased in type 2 diabetic patients

Liani, Rossella ; Halvorsen, Bente ; Sestili, Simona ; [et al.]

Elsevier BV ; 2012

In: Free Radical Biology and Medicine Vol. 52, No. 8 ( 2012-04), p. 1318-1324

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In: Free Radical Biology and Medicine, Elsevier BV, Vol. 52, No. 8 ( 2012-04), p. 1318-1324

Type of Medium: Online Resource

ISSN: 0891-5849

URL: Article

DOI: 10.1016/j.freeradbiomed.2012.02.012

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 1483653-1

SSG: 12

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Inflammation, oxidative stress and platelet activation in aspirin-treated critical limb ischaemia: Beneficial effects of iloprost

Cuccurullo, Chiara ; Di Michele, Dario ; Laurora, Giuseppe ; [et al.]

Georg Thieme Verlag KG ; 2011

In: Thrombosis and Haemostasis Vol. 105, No. 02 ( 2011), p. 321-328

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In: Thrombosis and Haemostasis, Georg Thieme Verlag KG, Vol. 105, No. 02 ( 2011), p. 321-328

Abstract: Platelets critically contribute to atherothrombosis and worsening ischaemia in patients with peripheral arterial disease (PAD), eventually leading to critical limb ischaemia (CLI). Furthermore, persistent platelet activation despite antiplatelet therapy has been reported in this setting. The prostacyclin analogue iloprost is currently recommended in CLI patients for its effects in relieving symptoms by promoting local perfusion. In this study, we investigated the effects of iloprost infusion on urinary 11-dehydro-TXB2 and 8-iso-PGF2α excretion rate, as in vivoindexes of thromboxane-dependent platelet activation and lipid peroxidation, respectively, and on platelet-derived proinflammatory sCD40L and nitric oxide bioavailability in 44 patients with CLI while on chronic treatment with low-dose aspirin. Daily iloprost infusion for one-week significantly decreased urinary 11-dehydro-TXB2 [499 (277 – 807) vs. 380 (189 – 560) pg/mg creatinine, p 〈 0.0001] and 8-iso-PGF2α [533 (316 – 842) vs. 334 (196 – 540) pg/mg creatinine, p 〈 0.0001] as well as plasma sCD40L [1540 (1005 – 3015) vs. 948 (845 – 2030) pg/ml, p 〈 0.0001]. Furthermore, a significant increase in plasma nitrate plus nitrite levels has been observed [26.8 (18.8 – 35.9) vs. 43.7 (33.0 – 75.5) μM, p 〈 0.0001]. A significant direct correlation was also found between urinary 8-iso-PGF2α and 11-dehydro-TXB2 before and after iloprost treatment (Rho = 0.695, p 〈 0.0001). In conclusion, we report that a short-term course of iloprost is able to significantly reduce residual thromboxane biosynthesis, oxidative stress, endothelial dysfunction and platelet-derived inflammation in low-dose aspirin treated patients with CLI.

Type of Medium: Online Resource

ISSN: 0340-6245 , 2567-689X

URL: Article

DOI: 10.1160/TH10-07-0499

Language: English

Publisher: Georg Thieme Verlag KG

Publication Date: 2011

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