In:
PLOS ONE, Public Library of Science (PLoS), Vol. 15, No. 12 ( 2020-12-2), p. e0242763-
Abstract:
In this study, we evaluated the efficacy of hydroxychloroquine (HCQ) against coronavirus disease 2019 (COVID-19) via a randomized controlled trial (RCT) and a retrospective study. Methods Subjects admitted to 11 designated public hospitals in Taiwan between April 1 and May 31, 2020, with COVID-19 diagnosis confirmed by pharyngeal real-time RT-PCR for SARS-CoV-2, were randomized at a 2:1 ratio and stratified by mild or moderate illness. HCQ (400 mg twice for 1 d or HCQ 200 mg twice daily for 6 days) was administered. Both the study and control group received standard of care (SOC). Pharyngeal swabs and sputum were collected every other day. The proportion and time to negative viral PCR were assessed on day 14. In the retrospective study, medical records were reviewed for patients admitted before March 31, 2020. Results There were 33 and 37 cases in the RCT and retrospective study, respectively. In the RCT, the median times to negative rRT-PCR from randomization to hospital day 14 were 5 days (95% CI; 1, 9 days) and 10 days (95% CI; 2, 12 days) for the HCQ and SOC groups, respectively ( p = 0.40). On day 14, 81.0% (17/21) and 75.0% (9/12) of the subjects in the HCQ and SOC groups, respectively, had undetected virus ( p = 0.36). In the retrospective study, 12 (42.9%) in the HCQ group and 5 (55.6%) in the control group had negative rRT-PCR results on hospital day 14 ( p = 0.70). Conclusions Neither study demonstrated that HCQ shortened viral shedding in mild to moderate COVID-19 subjects.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0242763
DOI:
10.1371/journal.pone.0242763.g001
DOI:
10.1371/journal.pone.0242763.g002
DOI:
10.1371/journal.pone.0242763.g003
DOI:
10.1371/journal.pone.0242763.t001
DOI:
10.1371/journal.pone.0242763.t002
DOI:
10.1371/journal.pone.0242763.t003
DOI:
10.1371/journal.pone.0242763.s001
DOI:
10.1371/journal.pone.0242763.s002
DOI:
10.1371/journal.pone.0242763.s003
DOI:
10.1371/journal.pone.0242763.s004
DOI:
10.1371/journal.pone.0242763.s005
DOI:
10.1371/journal.pone.0242763.s006
DOI:
10.1371/journal.pone.0242763.s007
DOI:
10.1371/journal.pone.0242763.s008
DOI:
10.1371/journal.pone.0242763.s009
DOI:
10.1371/journal.pone.0242763.r001
DOI:
10.1371/journal.pone.0242763.r002
DOI:
10.1371/journal.pone.0242763.r003
DOI:
10.1371/journal.pone.0242763.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2020
detail.hit.zdb_id:
2267670-3
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