In:
Liver International, Wiley, Vol. 34, No. 2 ( 2014-02), p. 220-226
Abstract:
Primary biliary cirrhosis ( PBC ) is an autoimmune liver disease. Genetic factors are critical in determining susceptibility to PBC . Among human leuocyte antigen ( HLA ) genes, an association between the DRB 1*08 allele and PBC has been reported in many populations, but not in Chinese patients. Methods We investigated HLA ‐A, B, DRB 1, and DQB 1 alleles and haplotypes in 145 PBC patients and 500 healthy subjects. Patients were also stratified according to autoantibody features, and associations between these and HLA alleles were analyzed. Results Significant associations existed between HLA ‐ DRB 1*08:03 (22.1% vs. 9.0%, Pc 〈 0.0001, OR = 2.86), DQ 2 (41.4% vs. 25.4%, Pc 〈 0.0001, OR = 2.07) and DQB 1*06:01 (31.0% vs. 17.8%, Pc = 0.014, OR = 2.08) alleles and PBC . DRB 1*08:03‐ DQB 1*06:01 (22.1% vs. 8.2%, P 〈 0.0001, OR = 3.17) and DRB 1*07:01‐ DQB 1*02:02 haplotypes (28.3% vs. 17.6%, P = 0.005, OR = 1.85) were also associated with PBC susceptibility. In contrast, the DQB 1*03:01 allele (21.4% vs. 39.2%, Pc 〈 0.0001, OR = 0.42) and DRB 1*12:02‐ DQB 1*03:01 haplotype (6.9% vs. 14.6%, P = 0.015, OR = 0.43) were significantly decreased in PBC patients compared with controls. DRB 1*14:54 and DQ 5(1) protected against antinuclear antibody ( ANA ) ( OR = 0.25) and anti‐gp210 antibody ( OR = 0.39) production, respectively, while HLA ‐B*44:03 predisposed patients to anti‐gp210 antibody ( OR = 5.70) production. Conclusion These results suggest that Chinese patients with PBC have a distinct genetic background in eastern Asia, and we confirmed the role of HLA genes in determining PBC susceptibility and autoantibody features in the Chinese population.
Type of Medium:
Online Resource
ISSN:
1478-3223
,
1478-3231
DOI:
10.1111/liv.2013.34.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2124684-1
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