In:
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, Wiley, Vol. 171, No. 6 ( 2016-09), p. 839-847
Abstract:
PARK16 was identified as a risk factor for Parkinson's disease in a Japanese cohort; however, subsequent studies in the other populations including the Chinese, European, Caucasian, and Chilean have shown a protective role instead. To investigate this locus in our Malaysian cohort, 1,144 individuals were screened for five SNPs in the PARK16 locus and logistic regression analysis showed that the A allele of the rs947211 SNP reduced the risk of developing PD via a recessive model (Odds ratio 0.57, P ‐value 0.0003). Pooled analysis with other Asian studies showed that A allele of the rs947211 SNP decreased the risk of developing PD via a recessive model (Odds ratio 0.71, P ‐value 0.0001). In addition, when meta‐analysis was performed with other Asian population, three SNPs (rs823128, rs823156, and rs11240572) reduced risk of developing PD via a dominant model. © 2016 Wiley Periodicals, Inc.
Type of Medium:
Online Resource
ISSN:
1552-4841
,
1552-485X
DOI:
10.1002/ajmg.b.v171.6
DOI:
10.1002/ajmg.b.32454
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2143866-3
SSG:
12
Bookmarklink