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  • 1
    Online Resource
    Online Resource
    Image_3.tif
    Frontiers Media SA ; 2022
    In:  Frontiers in Oncology Vol. 12 ( 2022-12-14)
    Details
    In: Frontiers in Oncology, Frontiers Media SA, Vol. 12 ( 2022-12-14)
    Abstract: In this study, DOTA-IBA was radiolabeled with 68 Ga and we determined the optimum labelling conditions and assessed the biological properties of 68 Ga-DOTA-IBA. We investigated the biodistribution of 68 Ga-DOTA-IBA in normal animals and undertook PET/CT imaging in humans. Finally, we explored the feasibility 68 Ga-DOTA-IBA as a bone imaging agent and demonstrated its potential for the therapeutic release of 177 Lu/ 225 Ac-DOTA-IBA. Methods The controlled variables method was used to assess the impact of variables on the radiochemical purity of 68 Ga-DOTA-IBA. The biological properties of 68 Ga-DOTA-IBA were investigated. 68 Ga-DOTA-IBA micro-PET/CT imaging was performed on animals. Volunteers were recruited for 68 Ga-DOTA-IBA imaging and data were compared to 99m Tc-MDP imaging studies to calculate the target to non-target ratio (T/NT) of the lesions. Results The prepared 68 Ga-DOTA-IBA had a radiochemical purity of & gt;97% and demonstrated good biological properties with a good safety profile in normal mice. PET/CT imaging of the animals showed rapid blood clearance with high contrast between the bone and stroma. Human imaging showed that 68 Ga-DOTA-IBA could detect more lesions compared to 99m Tc-MDP and had a higher targeted to untargeted ratio. Conclusions 68 Ga-DOTA-IBA is an osteophilic radiopharmaceutical that can be synthesized using a simple labelling method. 68 Ga-DOTA-IBA has high radiochemical purity and is stable in vitro stability. It is rapidly cleared from the blood, has low toxicity and has strong targeting to the bone with long retention times. We also found that it is rapidly cleared in non-target tissues and has high contrast on whole-body bone imaging. 68 Ga-DOTA-IBA PET/CT has potential as a novel bone imaging bone modality in patients with metastatic disease.
    Type of Medium: Online Resource
    ISSN: 2234-943X
    URL: Article
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fonc.2022.1027792
    DOI: 10.3389/fonc.2022.1027792.s001
    DOI: 10.3389/fonc.2022.1027792.s002
    DOI: 10.3389/fonc.2022.1027792.s003
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
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  • 2
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    Online Resource
    Statistical study of substorm timing sequence : STUDY OF SUBSTORM TIMING
    American Geophysical Union (AGU) ; 2009
    In:  Journal of Geophysical Research: Space Physics Vol. 114, No. A12 ( 2009-12), p. n/a-n/a
    Details
    In: Journal of Geophysical Research: Space Physics, American Geophysical Union (AGU), Vol. 114, No. A12 ( 2009-12), p. n/a-n/a
    Type of Medium: Online Resource
    ISSN: 0148-0227
    URL: Article
    DOI: 10.1029/2009JA014381
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2009
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    detail.hit.zdb_id: 3094268-8
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    SSG: 16,13
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  • 3
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    Online Resource
    VLF wave activity in the solar wind and the photoelectron effect in electric field measurements: Ulysses observations
    American Geophysical Union (AGU) ; 2003
    In:  Geophysical Research Letters Vol. 30, No. 19 ( 2003)
    Details
    In: Geophysical Research Letters, American Geophysical Union (AGU), Vol. 30, No. 19 ( 2003)
    Type of Medium: Online Resource
    ISSN: 0094-8276
    URL: Article
    DOI: 10.1029/2003GL017244
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2003
    detail.hit.zdb_id: 2021599-X
    detail.hit.zdb_id: 7403-2
    SSG: 16,13
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  • 4
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    Online Resource
    Very low frequency waves in the heliosphere: Ulysses observations
    American Geophysical Union (AGU) ; 1998
    In:  Journal of Geophysical Research: Space Physics Vol. 103, No. A6 ( 1998-06), p. 12023-12035
    Details
    In: Journal of Geophysical Research: Space Physics, American Geophysical Union (AGU), Vol. 103, No. A6 ( 1998-06), p. 12023-12035
    Abstract: An overall profile of plasma wave activity in a frequency range of 0.2 to 448 Hz in the solar wind is presented using 6 years of Ulysses data which cover a large range of heliographic latitudes (0° to ±80°) at distances from 1 to 5 AU from the Sun. The spacecraft has continuously observed wave activity with peak power below the local electron cyclotron frequency ƒ ce . Four distinct types of fluctuation phenomena have been observed: (1) enhanced electromagnetic fluctuations associated with the interplanetary shocks and heliospheric current sheet crossings and other solar wind turbulence; (2) enhanced electromagnetic fluctuations associated with compression regions of high‐speed stream interfaces, which were observed in periods of increasing solar wind velocity; (3) electric fluctuations associated with the expanding solar wind, which were observed in periods of decreasing solar wind velocity; and (4) enhanced electric fluctuations in the high‐latitude fast solar wind plasma. The fourth type of wave activity was observed nearly continuously with the relative power observed peaked near the local ƒ ce . The first three types of waves were observed in the heliomagnetic streamer belt flows, where the spacecraft frequently encountered enhanced solar wind turbulence, interplanetary shocks, and current sheet crossings. The electromagnetic wave bursts (types 1 and 2) are likely to be whistler mode. The occurrences of apparently electrostatic waves during periods of expanding solar wind are coincident with significant reductions in the electron heat flux intensity. The generation mechanism of these electrostatic waves is still under investigation, but the observations may imply that these waves reduce the intensity of the heat flux through enhanced wave particle scattering associated with a heat flux instability.
    Type of Medium: Online Resource
    ISSN: 0148-0227
    URL: Article
    DOI: 10.1029/98JA00764
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 1998
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    detail.hit.zdb_id: 161667-5
    detail.hit.zdb_id: 2969341-X
    detail.hit.zdb_id: 161665-1
    detail.hit.zdb_id: 3094268-8
    detail.hit.zdb_id: 710256-2
    detail.hit.zdb_id: 2016804-4
    detail.hit.zdb_id: 3094181-7
    detail.hit.zdb_id: 3094219-6
    detail.hit.zdb_id: 3094167-2
    detail.hit.zdb_id: 2220777-6
    detail.hit.zdb_id: 3094197-0
    SSG: 16,13
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  • 5
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    Online Resource
    Low frequency plasma waves in the solar wind: From ecliptic plane to the solar polar regions
    Elsevier BV ; 1997
    In:  Advances in Space Research Vol. 19, No. 6 ( 1997-1), p. 877-881
    Details
    In: Advances in Space Research, Elsevier BV, Vol. 19, No. 6 ( 1997-1), p. 877-881
    Type of Medium: Online Resource
    ISSN: 0273-1177
    URL: Article
    DOI: 10.1016/S0273-1177(97)00296-2
    Language: English
    Publisher: Elsevier BV
    Publication Date: 1997
    detail.hit.zdb_id: 2023311-5
    SSG: 16,12
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  • 6
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    Online Resource
    Accuracy of Gallium-68 Pentixafor Positron Emission Tomography–Computed Tomography for Subtyping Diagnosis of Primary Aldosteronism
    American Medical Association (AMA) ; 2023
    In:  JAMA Network Open Vol. 6, No. 2 ( 2023-02-16), p. e2255609-
    Details
    In: JAMA Network Open, American Medical Association (AMA), Vol. 6, No. 2 ( 2023-02-16), p. e2255609-
    Abstract: Adrenal vein sampling (AVS) is the recommended procedure for subtyping primary aldosteronism (PA) as unilateral PA (UPA) or bilateral PA (BPA), with different treatment needed for each: adrenalectomy for UPA and medication for BPA. However, AVS is invasive and technically difficult, and how to subtype PA noninvasively is currently a great challenge. Objective To evaluate the accuracy of gallium-68 pentixafor positron emission tomography–computed tomography (PET-CT) in subtyping PA using AVS as a reference standard. Design, Setting, and Participants This diagnostic study was conducted at a tertiary hospital in China among patients diagnosed with PA. Enrollment was started in November 2021, with follow-up ending in May 2022. Exposures : Patients were recruited to undergo gallium-68 pentixafor PET-CT and AVS. Main Outcomes and Measures Maximum standardized uptake value (SUVmax) of each adrenal gland during PET-CT was measured to calculate the lateralization index of SUVmax. Area under the receiver operating characteristic curve (AUROC), specificity, and sensitivity were used to analyze the accuracy of the lateralization index based on SUVmax for subtyping PA. Results Among 100 patients with PA who completed the study (47 female [47.0%] and 53 male [53.0%] ; median [IQR] age, 49 [38-56] years), 43 individuals had UPA and 57 individuals had BPA. Aldosterone-cortisol ratio (Spearman ρ = 0.26; P   & amp;lt; .001) in adrenal veins was positively correlated with SUVmax of adrenal glands at 10 minutes during PET-CT. Using lateralization index based on SUVmax at 10 minutes to identify UPA, the AUROC was 0.90 (95% CI, 0.83-0.97). A cutoff value for lateralization index based on SUVmax at 10 minutes set at 1.65 conferred a specificity of 1.00 (95% CI, 0.94-1.00) and sensitivity of 0.77 (95% CI, 0.61-0.88). The diagnostic concordance rate of PET-CT and AVS was 90 patients (90.0%) compared with 54 patients (54.0%) between traditional CT and AVS. Conclusions and Relevance This study found good diagnostic accuracy of gallium-68 pentixafor PET-CT in differentiating UPA from BPA. These findings suggest that gallium-68 pentixafor PET-CT may be used to avoid invasive AVS in some patients with PA.
    Type of Medium: Online Resource
    ISSN: 2574-3805
    URL: Article
    DOI: 10.1001/jamanetworkopen.2022.55609
    Language: English
    Publisher: American Medical Association (AMA)
    Publication Date: 2023
    detail.hit.zdb_id: 2931249-8
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  • 7
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    Online Resource
    Solar cycle variations in the electron heat flux: Ulysses observations
    American Geophysical Union (AGU) ; 2001
    In:  Geophysical Research Letters Vol. 28, No. 11 ( 2001-06), p. 2169-2172
    Details
    In: Geophysical Research Letters, American Geophysical Union (AGU), Vol. 28, No. 11 ( 2001-06), p. 2169-2172
    Abstract: Solar wind observations by the Ulysses spacecraft now include nearly ten years of continuous ion and electron measurements. In this study, we report detailed measurements of the electron heat flux in the solar wind. In particular, we examine the heat flux measurements for long‐term correlations with wave activity and solar wind speed. We find that the average heat flux, when scaled by R 2.9 to account for variations due to distance from the Sun, is constant and independent of heliographic latitude or solar cycle. We find that during both solar maximum and solar minimum, there is no significant correlation between the magnitude of the electron heat flux and the solar wind speed. Comparison of the electron heat flux data with wave activity indicates that the whistler heat flux instability does not play an important role in limiting the solar wind heat flux.
    Type of Medium: Online Resource
    ISSN: 0094-8276 , 1944-8007
    URL: Article
    DOI: 10.1029/2001GL012925
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 2001
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    detail.hit.zdb_id: 7403-2
    SSG: 16,13
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  • 8
    Online Resource
    Online Resource
    ULF waves in the Io torus: Ulysses observations
    American Geophysical Union (AGU) ; 1993
    In:  Journal of Geophysical Research: Space Physics Vol. 98, No. A12 ( 1993-12), p. 21151-21162
    Details
    In: Journal of Geophysical Research: Space Physics, American Geophysical Union (AGU), Vol. 98, No. A12 ( 1993-12), p. 21151-21162
    Abstract: Throughout the Io torus, Ulysses has observed intense ULF wave activity in both electric and magnetic components. Such ULF waves have been previously suggested as the source of ion precipitation leading to Jovian aurorae. The peaks of the wave spectra are closely related to the ion cyclotron frequencies, which is evidence of the waves being ion cyclotron waves (ICWs). Analysis of the dispersion relation using a multicomponent density model shows that at high latitudes (∼ 30°), peak frequencies of the waves fall into L mode branches of guided or unguided ICWs. Near the equator, in addition to the ICWs below fnof; c O ++, there are strong signals at ∼10 Hz which require an unexpectedly large energetic ion temperature anisotropy to be explained by the excitation of either convective or nonconvective ion cyclotron instabilities. Their generation mechanism remains open for the future study. Evaluation of the Poynting vector and the dispersion relation analysis suggest that the waves near the equator had a small wave angle relative to the magnetic field, while those observed at high latitudes were more oblique. The polarization of the waves below fnof; c H + is more random than that of the whistler mode waves, but left‐hand‐polarized components of the waves can still be seen. The intensity of the ICWs both near the equator and at high latitudes are strong enough to meet the requirement for producing strong pitch angle scattering of energetic ions.
    Type of Medium: Online Resource
    ISSN: 0148-0227
    URL: Article
    DOI: 10.1029/93JA02593
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 1993
    detail.hit.zdb_id: 2033040-6
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    detail.hit.zdb_id: 161665-1
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    detail.hit.zdb_id: 3094197-0
    SSG: 16,13
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  • 9
    Online Resource
    Online Resource
    Observations of plasma waves in magnetic holes
    American Geophysical Union (AGU) ; 1995
    In:  Geophysical Research Letters Vol. 22, No. 23 ( 1995-12-01), p. 3417-3420
    Details
    In: Geophysical Research Letters, American Geophysical Union (AGU), Vol. 22, No. 23 ( 1995-12-01), p. 3417-3420
    Type of Medium: Online Resource
    ISSN: 0094-8276
    URL: Article
    DOI: 10.1029/95GL03266
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 1995
    detail.hit.zdb_id: 2021599-X
    detail.hit.zdb_id: 7403-2
    SSG: 16,13
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  • 10
    Online Resource
    Online Resource
    Whistler mode waves in the Jovian magnetosheath
    American Geophysical Union (AGU) ; 1994
    In:  Journal of Geophysical Research: Space Physics Vol. 99, No. A12 ( 1994-12), p. 23527-23539
    Details
    In: Journal of Geophysical Research: Space Physics, American Geophysical Union (AGU), Vol. 99, No. A12 ( 1994-12), p. 23527-23539
    Abstract: During the Ulysses flyby of Jupiter in February 1992, the spacecraft traversed the Jovian magnetosheath for a few hours during the inbound pass and for a few days during the outbound pass. Burstlike electromagnetic waves at frequencies of ∼0.1‐0.4 of the local electron cyclotron frequency have been observed by the Unified Radio and Plasma Wave (URAP) experiment. The waves were more often observed in the regions which were probably the outer or middle magnetosheath, especially near the bow shock, and rarely seen in the magnetosphere/magnetosheath boundary layer. The propagation angles of the waves are estimated by comparing the measurements of the wave electric and magnetic fields in the spacecraft spin plane with the corresponding values calculated using the cold plasma dispersion relation under local field and plasma conditions. It is found that the waves propagate obliquely with wave angles between ∼30° and 50°. These waves are likely to be the whistler mode waves which are excited by suprathermal electrons with a few hundred eV and a slight anisotropy ( T ⊥ / T ∥ ∼1.1‐1.5). They are probably similar in nature to the lion roars observed in the Earth's magnetosheath. Signature of coupling between the mirror mode and the whistler mode have also been observed. The plasma conditions which favor the excitation of the whistler mode instability during the wave events exist as observed by the plasma experiment of Ulysses.
    Type of Medium: Online Resource
    ISSN: 0148-0227
    URL: Article
    DOI: 10.1029/94JA01998
    Language: English
    Publisher: American Geophysical Union (AGU)
    Publication Date: 1994
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    detail.hit.zdb_id: 2220777-6
    detail.hit.zdb_id: 3094197-0
    SSG: 16,13
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