In:
Scientific Reports, Springer Science and Business Media LLC, Vol. 10, No. 1 ( 2020-12-01)
Abstract:
This study was designed to identify whether the position and size of the
region of interest (ROI) influence extracellular volume fraction (ECV) measurements. Patients with localized (n = 203) or infiltrative (n = 215) cardiomyopathies and 36
normal controls were enrolled in this study. ECV measurements at 4 different regions, including the anterior, septal, posterior and lateral wall regions, were measured, and
all groups were compared. Regional ECV was correlated with the corresponding regional wall thickness. The diagnostic power to differentiate the myocardial abnormalities was
evaluated for each myocardial region. ECVs measured using five different ROI sizes within each myocardial region were compared. Our results showed that ECVs varied among
the myocardial regions, and this variation was significantly associated with regional wall thicknesses. For the detection of myocardial abnormalities, regional ECV revealed
similar results as ECV derived from the whole region except for the anterior region. No significant difference was found in the ECVs measured using the five different ROI
sizes. In conclusion, CMR-derived ECVs vary with myocardial region, and this variation is significantly associated with the regional wall thickness. In contrast, the measured
size of the ROI has less of an effect on the ECV.
Type of Medium:
Online Resource
ISSN:
2045-2322
DOI:
10.1038/s41598-020-78043-5
Language:
English
Publisher:
Springer Science and Business Media LLC
Publication Date:
2020
detail.hit.zdb_id:
2615211-3
Bookmarklink