In:
BJU International, Wiley, Vol. 118, No. 2 ( 2016-08), p. 313-319
Abstract:
To prospectively investigate the association of endothelial nitric oxide synthase ( eNOS ) G894T gene polymorphism with responsiveness to a selective α 1 ‐blocker in men with benign prostatic hyperplasia related lower urinary tract symptoms ( BPH / LUTS ), as nitric oxide has recently gained increasing recognition as an important neurotransmitter of functions in the lower urinary tract. Patients and Methods In all, 136 men with BPH / LUTS were recruited from urology outpatient clinics in a university hospital. Oral therapy with doxazosin gastrointestinal therapeutic system ( GITS ) 4 mg once‐daily was given for 12 weeks. The drug efficacy was assessed by the changes from baseline in the total International Prostate Symptom Score ( IPSS ), maximum urinary flow rate ( Q max ) and post‐void residual urine volume ( PVR ) at 12 weeks of treatment. The ‘responders’ to doxazosin GITS were defined as those who had a total IPSS decrease of 〉 4 points from baseline. eNOS G894T polymorphism was determined using the polymerase chain reaction‐restriction fragment length polymorphism method. Results Patients had statistically significant improvements in total IPSS , quality of life score, and Q max ( P 〈 0.01) after a 12‐week period of treatment. Using multiple logistic regression analysis adjusted for age and IPSS , our results showed that being a eNOS 894T allele carrier was an independent risk factor for being a drug non‐responder ( P = 0.03, odds ratio 4.19). Moreover, a decreased responder rate ( P = 0.01), as well as the lower improvements in IPSS ( P = 0.02) and Q max ( P = 0.03) were significantly associated with increment in the T allele number. Conclusions The presence of the eNOS 894T allele had a significantly negative impact on responsiveness to a selective α 1 ‐blocker in BPH / LUTS treatment, suggesting that eNOS G894T gene polymorphism may be a genetic susceptibility factor for α 1 ‐blocker efficacy in men with BPH /LUTS.
Type of Medium:
Online Resource
ISSN:
1464-4096
,
1464-410X
DOI:
10.1111/bju.2016.118.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
2019983-1
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