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Global access to technologies to support safe and effective inguinal hernia surgery: prospective, international cohort study

National Institute for Health and Care Research (NIHR) Global Health Research Unit on Global Surgery ; Picciochi, M ; Ademuyiwa, A O ; [et al.]

Oxford University Press (OUP) ; 2024

In: British Journal of Surgery Vol. 111, No. 7 ( 2024-07-02)

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In: British Journal of Surgery, Oxford University Press (OUP), Vol. 111, No. 7 ( 2024-07-02)

Type of Medium: Online Resource

ISSN: 0007-1323 , 1365-2168

URL: Article

DOI: 10.1093/bjs/znae164

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2024

detail.hit.zdb_id: 2006309-X

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Inhibition of Staphyloxanthin Virulence Factor Biosynthesis in Staphylococcus aureus : In Vitro, in Vivo, and Crystallographic Results

Song, Yongcheng ; Liu, Chia-I ; Lin, Fu-Yang ; [et al.]

American Chemical Society (ACS) ; 2009

In: Journal of Medicinal Chemistry Vol. 52, No. 13 ( 2009-07-09), p. 3869-3880

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In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 52, No. 13 ( 2009-07-09), p. 3869-3880

Type of Medium: Online Resource

ISSN: 0022-2623 , 1520-4804

URL: Article

DOI: 10.1021/jm9001764

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2009

detail.hit.zdb_id: 1491411-6

SSG: 15,3

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Mortality Risk Profiling of Staphylococcus aureus Bacteremia by Multi-omic Serum Analysis Reveals Early Predictive and Pathogenic Signatures

Wozniak, Jacob M. ; Mills, Robert H. ; Olson, Joshua ; [et al.]

Elsevier BV ; 2020

In: Cell Vol. 182, No. 5 ( 2020-09), p. 1311-1327.e14

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In: Cell, Elsevier BV, Vol. 182, No. 5 ( 2020-09), p. 1311-1327.e14

Type of Medium: Online Resource

ISSN: 0092-8674

URL: Article

DOI: 10.1016/j.cell.2020.07.040

RVK:

XA 36269

RVK:

WA 15000

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 187009-9

detail.hit.zdb_id: 2001951-8

SSG: 12

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Comparative transcriptome analysis of acne vulgaris, rosacea, and hidradenitis suppurativa supports high‐dose dietary zinc as a therapeutic agent

Li, Li ; Hajam, Irshad ; McGee, Jean S. ; [et al.]

Wiley ; 2024

In: Experimental Dermatology Vol. 33, No. 7 ( 2024-07)

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In: Experimental Dermatology, Wiley, Vol. 33, No. 7 ( 2024-07)

Abstract: Acne vulgaris, rosacea, and hidradenitis suppurativa are enduring inflammatory skin conditions that frequently manifest with akin clinical attributes, posing a considerable challenge for their distinctive diagnosis. While these conditions do exhibit certain resemblances, they also demonstrate distinct underlying pathophysiological mechanisms and treatment modalities. Delving into both the molecular parallels and disparities among these three disorders can yield invaluable insights for refined diagnostics, effective management, and targeted therapeutic interventions. In this report, we present a comparative analysis of transcriptomic data across these three diseases, elucidating differentially expressed genes and enriched pathways specific to each ailment, as well as those shared among them. Specifically, we identified multiple zinc‐binding proteins (SERPINA1, S100A7, S100A8, S100A9 and KRT16) as consistently highly upregulated genes across all three diseases. Our hypothesis suggests that these proteins could bind and sequester zinc, potentially leading to localized zinc deficiency and heightened inflammation. We identified high‐dose dietary zinc as a promising therapeutic approach and confirmed its effectiveness through validation in an acne mouse model.

Type of Medium: Online Resource

ISSN: 0906-6705 , 1600-0625

URL: Issue

URL: Article

DOI: 10.1111/exd.v33.7

DOI: 10.1111/exd.15145

RVK:

XA 42446

Language: English

Publisher: Wiley

Publication Date: 2024

detail.hit.zdb_id: 2026228-0

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Detection of a TLR 2 agonist by hematopoietic stem and progenitor cells impacts the function of the macrophages they produce

Yáñez, Alberto ; Hassanzadeh‐Kiabi, Nargess ; Ng, Madelena Y. ; [et al.]

Wiley ; 2013

In: European Journal of Immunology Vol. 43, No. 8 ( 2013-08), p. 2114-2125

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In: European Journal of Immunology, Wiley, Vol. 43, No. 8 ( 2013-08), p. 2114-2125

Abstract: Several groups have shown that detection of microbial components by TLR s on hematopoietic stem and progenitor cells ( HSPC s) instructs myeloid cell generation, raising interest in the possibility of targeting TLR s on HSPC s to boost myelopoiesis. However, although “ TLR ‐derived” cells exhibit myeloid cell characteristics (phagocytosis, cytokine production, antigen presentation), it is not clear whether they are functionally equivalent to macrophages derived in the absence of TLR activation. Our in vitro and in vivo studies show that macrophages derived from mouse and human HSPC subsets (including stem cells) exposed to a TLR 2 agonist prior to or during macrophage differentiation produce lower levels of inflammatory cytokines ( TNF ‐α, IL ‐6, and IL ‐1β) and reactive oxygen species. This is in contrast to prior exposure of differentiated macrophages to the TLR 2 agonist (“tolerance”), which suppresses inflammatory cytokine production, but elevates reactive oxygen species. Soluble factors produced following exposure of HSPC s to a TLR 2 agonist can also act in a paracrine manner to influence the function of macrophages derived from unexposed HSPC s. Our data demonstrate that macrophage function can be influenced by TLR signaling in the HSPC s from which they are derived, and that this may impact the clinical utility of targeting TLR s on HSPC s to boost myelopoiesis.

Type of Medium: Online Resource

ISSN: 0014-2980 , 1521-4141

URL: Issue

URL: Article

DOI: 10.1002/eji.v43.8

DOI: 10.1002/eji.201343403

RVK:

XA 10000

Language: English

Publisher: Wiley

Publication Date: 2013

detail.hit.zdb_id: 1491907-2

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EBV + high‐grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements: a multi‐institutional study

Liu, Hui ; Xu‐Monette, Zijun Y ; Tang, Guilin ; [et al.]

Wiley ; 2022

In: Histopathology Vol. 80, No. 3 ( 2022-02), p. 575-588

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In: Histopathology, Wiley, Vol. 80, No. 3 ( 2022-02), p. 575-588

Abstract: It is unknown whether Epstein–Barr virus (EBV) infection can occur in high‐grade B cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements, also known as double‐ or triple‐hit lymphoma (DHL/THL). Methods and results Here we report 16 cases of EBV + DHL/THL from screening 846 cases of DHL/THL and obtaining additional EBV + cases through multi‐institutional collaboration: eight MYC and BCL2 DHL, six MYC and BCL6 DHL and two THL. There were eight men and eight women, with a median age of 65 years (range = 32–86). Two patients had a history of follicular lymphoma and one had AIDS. Nine of 14 patients had an International Prognostic Index of ≥3. Half of the cases showed high‐grade/Burkitt‐like morphology and the other half diffuse large B cell lymphoma morphology. Using immunohistochemistry, the lymphoma cells were positive for MYC ( n = 14 of 16), BCL2 ( n = 12 of 16), BCL6 ( n = 14 of 16), CD10 ( n = 13 of 16) and MUM1 ( n = six of 14). Using Hans’ algorithm, 13 cases were classified as germinal centre B cell (GCB) and three as non‐GCB. The lymphomas frequently showed an EBV latency Type I with a median EBV‐encoded small RNAs of 80% positive cells (range = 20–100%). After a median follow‐up of 36.3 months (range = 2.0–41.6), seven patients died, with a median survival of 15.4 months (range = 3.4–47.3) after diagnosis of EBV + DHL/THL. Five of six patients with MYC and BCL6 DHL were alive, including four in complete remission. In contrast, only four of 10 patients with MYC and BCL2 DHL or THL were alive, including two in complete remission. The median survival in patients with MYC and BCL6 DHL was unreached and was 21.6 months in patients with MYC and BCL2 DHL or THL. Conclusions EBV infection in DHL/THL is rare (~1.5%). Cases of EBV + DHL/THL are largely similar to their EBV – counterparts clinicopathologically. Our findings expand the spectrum of EBV + B cell lymphomas currently recognised in the World Health Organisation classification and suggest differences between EBV + MYC and BCL2 DHL versus EBV+ MYC and BCL6 DHL that may have therapeutic implications.

Type of Medium: Online Resource

ISSN: 0309-0167 , 1365-2559

URL: Issue

URL: Article

DOI: 10.1111/his.v80.3

DOI: 10.1111/his.14585

RVK:

XA 10000

Language: English

Publisher: Wiley

Publication Date: 2022

detail.hit.zdb_id: 2006447-0

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Direct Antimicrobial Activity of IFN-β

Kaplan, Amber ; Lee, Michelle W. ; Wolf, Andrea J. ; [et al.]

The American Association of Immunologists ; 2017

In: The Journal of Immunology Vol. 198, No. 10 ( 2017-05-15), p. 4036-4045

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In: The Journal of Immunology, The American Association of Immunologists, Vol. 198, No. 10 ( 2017-05-15), p. 4036-4045

Abstract: Type I IFNs are a cytokine family essential for antiviral defense. More recently, type I IFNs were shown to be important during bacterial infections. In this article, we show that, in addition to known cytokine functions, IFN-β is antimicrobial. Parts of the IFN-β molecular surface (especially helix 4) are cationic and amphipathic, both classic characteristics of antimicrobial peptides, and we observed that IFN-β can directly kill Staphylococcus aureus. Further, a mutant S. aureus that is more sensitive to antimicrobial peptides was killed more efficiently by IFN-β than was the wild-type S. aureus, and immunoblotting showed that IFN-β interacts with the bacterial cell surface. To determine whether specific parts of IFN-β are antimicrobial, we synthesized IFN-β helix 4 and found that it is sufficient to permeate model prokaryotic membranes using synchrotron x-ray diffraction and that it is sufficient to kill S. aureus. These results suggest that, in addition to its well-known signaling activity, IFN-β may be directly antimicrobial and be part of a growing family of cytokines and chemokines, called kinocidins, that also have antimicrobial properties.

Type of Medium: Online Resource

ISSN: 0022-1767 , 1550-6606

URL: Article

DOI: 10.4049/jimmunol.1601226

RVK:

XA 54100

RVK:

XA 10000

Language: English

Publisher: The American Association of Immunologists

Publication Date: 2017

detail.hit.zdb_id: 1475085-5

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A Cholesterol Biosynthesis Inhibitor Blocks Staphylococcus aureus Virulence

Liu, Chia-I ; Liu, George Y. ; Song, Yongcheng ; [et al.]

American Association for the Advancement of Science (AAAS) ; 2008

In: Science Vol. 319, No. 5868 ( 2008-03-07), p. 1391-1394

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In: Science, American Association for the Advancement of Science (AAAS), Vol. 319, No. 5868 ( 2008-03-07), p. 1391-1394

Abstract: Staphylococcus aureus produces hospital- and community-acquired infections, with methicillin-resistant S. aureus posing a serious public health threat. The golden carotenoid pigment of S. aureus , staphyloxanthin, promotes resistance to reactive oxygen species and host neutrophil-based killing, and early enzymatic steps in staphyloxanthin production resemble those for cholesterol biosynthesis. We determined the crystal structures of S. aureus dehydrosqualene synthase (CrtM) at 1.58 angstrom resolution, finding structural similarity to human squalene synthase (SQS). We screened nine SQS inhibitors and determined the structures of three, bound to CrtM. One, previously tested for cholesterol-lowering activity in humans, blocked staphyloxanthin biosynthesis in vitro (median inhibitory concentration ∼100 nM), resulting in colorless bacteria with increased susceptibility to killing by human blood and to innate immune clearance in a mouse infection model. This finding represents proof of principle for a virulence factor–based therapy against S. aureus .

Type of Medium: Online Resource

ISSN: 0036-8075 , 1095-9203

URL: Article

DOI: 10.1126/science.1153018

RVK:

TA 1000

RVK:

WA 15000

Language: English

Publisher: American Association for the Advancement of Science (AAAS)

Publication Date: 2008

detail.hit.zdb_id: 128410-1

detail.hit.zdb_id: 2066996-3

detail.hit.zdb_id: 2060783-0

SSG: 11

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Review of Optical Humidity Sensors

Rao, Xing ; Zhao, Lin ; Xu, Lukui ; [et al.]

MDPI AG ; 2021

In: Sensors Vol. 21, No. 23 ( 2021-12-01), p. 8049-

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In: Sensors, MDPI AG, Vol. 21, No. 23 ( 2021-12-01), p. 8049-

Abstract: Optical humidity sensors have evolved through decades of research and development, constantly adapting to new demands and challenges. The continuous growth is supported by the emergence of a variety of optical fibers and functional materials, in addition to the adaptation of different sensing mechanisms and optical techniques. This review attempts to cover the majority of optical humidity sensors reported to date, highlight trends in design and performance, and discuss the challenges of different applications.

Type of Medium: Online Resource

ISSN: 1424-8220

URL: Article

DOI: 10.3390/s21238049

Language: English

Publisher: MDPI AG

Publication Date: 2021

detail.hit.zdb_id: 2052857-7

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A mobility-aware dynamic database caching scheme for wireless mobile computing and communications

Liu, George Y. ; Maguire, Gerald Q.

Springer Science and Business Media LLC ; 1996

In: Distributed and Parallel Databases Vol. 4, No. 3 ( 1996-7), p. 271-288

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In: Distributed and Parallel Databases, Springer Science and Business Media LLC, Vol. 4, No. 3 ( 1996-7), p. 271-288

Type of Medium: Online Resource

ISSN: 0926-8782 , 1573-7578

URL: Article

DOI: 10.1007/BF00140953

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 1996

detail.hit.zdb_id: 913166-8

detail.hit.zdb_id: 1475521-X

SSG: 24,1

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