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Functional Genetic Polymorphisms in CYP2C19 Gene in Relation to Cardiac Side Effects and Treatment Dose in a Methadone Maintenance Cohort

Wang, Sheng-Chang ; Ho, Ing-Kang ; Tsou, Hsiao-Hui ; [et al.]

Mary Ann Liebert Inc ; 2013

In: OMICS: A Journal of Integrative Biology Vol. 17, No. 10 ( 2013-10), p. 519-526

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In: OMICS: A Journal of Integrative Biology, Mary Ann Liebert Inc, Vol. 17, No. 10 ( 2013-10), p. 519-526

Type of Medium: Online Resource

ISSN: 1536-2310 , 1557-8100

URL: Article

DOI: 10.1089/omi.2012.0068

Language: English

Publisher: Mary Ann Liebert Inc

Publication Date: 2013

detail.hit.zdb_id: 2030312-9

SSG: 12

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CYP1A2 genetic polymorphisms are associated with early antidepressant escitalopram metabolism and adverse reactions

Kuo, Hsiang-Wei ; Liu, Shu Chih ; Tsou, Hsiao-Hui ; [et al.]

Future Medicine Ltd ; 2013

In: Pharmacogenomics Vol. 14, No. 10 ( 2013-07), p. 1191-1201

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In: Pharmacogenomics, Future Medicine Ltd, Vol. 14, No. 10 ( 2013-07), p. 1191-1201

Abstract: Aim: The liver CYP1A2 enzyme may metabolize antidepressant escitalopram (S-CIT) to S-desmethylcitalopram (S-DCIT) and S-didesmethylcitalopram (S-DDCIT). This study tested whether genetic polymorphisms in the CYP1A2 gene are associated with the treatment responses to S-CIT. Materials & methods: Ten SNPs in CYP1A2 were selected and genotyped in 158 patients under S-CIT treatment. The serum levels of S-CIT and its metabolites were measured by HPLC. Results:CYP1A2 SNPs rs2069521, rs2069526, rs4646425 and rs4646427 are significantly associated with the metabolic ratios of S-DDCIT/S-DCIT (p = 0.002, 0.018, 0.008 and 0.004, respectively) at week 2 of treatment. Carriers of the allele types associated with higher S-DDCIT/S-DCIT ratios had more severe side effects. Conclusion: These results suggest that genetic variants in CYP1A2 may be indicators for S-CIT metabolism and that the fast metabolizers may experience more severe adverse reactions in the early stages of S-CIT treatment. Original submitted 27 December 2012; Revision submitted 15 May 2013

Type of Medium: Online Resource

ISSN: 1462-2416 , 1744-8042

URL: Article

DOI: 10.2217/pgs.13.105

Language: English

Publisher: Future Medicine Ltd

Publication Date: 2013

SSG: 15,3

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Chemokine IP-10 is correlated with cardiac responses and status of infection with HIV and HCV in methadone maintenance patients

Liu, Sheng-Wen ; Liu, Yu-Li ; Hwang, Ling-Ling ; [et al.]

Elsevier BV ; 2015

In: International Journal of Cardiology Vol. 194 ( 2015-09), p. 36-38

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In: International Journal of Cardiology, Elsevier BV, Vol. 194 ( 2015-09), p. 36-38

Type of Medium: Online Resource

ISSN: 0167-5273

URL: Article

DOI: 10.1016/j.ijcard.2015.05.055

Language: English

Publisher: Elsevier BV

Publication Date: 2015

detail.hit.zdb_id: 1500478-8

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Hepatitis C Virus Infection Influences the S-Methadone Metabolite Plasma Concentration

Wu, Shiow-Ling ; Wang, Sheng-Chang ; Tsou, Hsiao-Hui ; [et al.]

Public Library of Science (PLoS) ; 2013

In: PLoS ONE Vol. 8, No. 7 ( 2013-7-23), p. e69310-

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In: PLoS ONE, Public Library of Science (PLoS), Vol. 8, No. 7 ( 2013-7-23), p. e69310-

Type of Medium: Online Resource

ISSN: 1932-6203

URL: Article

DOI: 10.1371/journal.pone.0069310

DOI: 10.1371/journal.pone.0069310.g001

DOI: 10.1371/journal.pone.0069310.g002

DOI: 10.1371/journal.pone.0069310.t001

DOI: 10.1371/journal.pone.0069310.t002

DOI: 10.1371/journal.pone.0069310.t003

DOI: 10.1371/journal.pone.0069310.s001

DOI: 10.1371/journal.pone.0069310.s002

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2013

detail.hit.zdb_id: 2267670-3

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Assessment of CYP450 genetic variability effect on methadone dose and tolerance

Tsai, Hui-Ju ; Wang, Sheng-Chang ; Liu, Sheng-Wen ; [et al.]

Future Medicine Ltd ; 2014

In: Pharmacogenomics Vol. 15, No. 7 ( 2014-05), p. 977-986

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In: Pharmacogenomics, Future Medicine Ltd, Vol. 15, No. 7 ( 2014-05), p. 977-986

Abstract: Aim: Methadone dose is related to treatment success in individuals under methadone maintenance treatment (MMT). We constructed a gene matrix using previously identified genetic polymorphisms in CYP450 and determined their genetic influence on methadone dose or tolerance. Materials & methods: The allelic combinations of CYP450 genetic variants (two from CYP2C19, four from CYP2B6 and five from CYP3A4) were analyzed in 366 MMT heroin dependent patients as possible determinants of methadone dose and tolerance using analysis of covariance. Results: Methadone dose (p = 0.007) and tolerance (p = 0.06) were mainly influenced by CYP2C19 gene dose. Moreover, dominant influence of the CYP2C19 gene dose on methadone dose and tolerance was only found among MMT patients with negative urine morphine test results, but not among those with positive results. Conclusion: The findings suggest that CYP2C19 gene dose may serve as a potential indicator for assessing methadone dose and tolerance in MMT patients. Original submitted 5 September 2013; Revision submitted 23 January 2014

Type of Medium: Online Resource

ISSN: 1462-2416 , 1744-8042

URL: Article

DOI: 10.2217/pgs.14.19

Language: English

Publisher: Future Medicine Ltd

Publication Date: 2014

SSG: 15,3

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[P4–355]: NEURODEGENERATION BIOMARKER EOTAXIN‐1 ELEVATED AT EARLY AGE IN HEROIN‐DEPENDENT PATIENTS

Liu, Yu‐Li ; Kuo, Hsiang‐Wei ; Liu, Sheng‐Wen ; [et al.]

Wiley ; 2017

In: Alzheimer's & Dementia Vol. 13, No. 7S_Part_29 ( 2017-07)

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In: Alzheimer's & Dementia, Wiley, Vol. 13, No. 7S_Part_29 ( 2017-07)

Type of Medium: Online Resource

ISSN: 1552-5260 , 1552-5279

URL: Article

DOI: 10.1016/j.jalz.2017.06.2226

Language: English

Publisher: Wiley

Publication Date: 2017

detail.hit.zdb_id: 2201940-6

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Engineering the Surface/Interface of Horizontally Oriented Carbon Nanotube Macrofilm for Foldable Lithium‐Ion Battery Withstanding Variable Weather

Liu, Ting ; Zhang, Ming ; Wang, Yong Long ; [et al.]

Wiley ; 2018

In: Advanced Energy Materials Vol. 8, No. 30 ( 2018-10)

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In: Advanced Energy Materials, Wiley, Vol. 8, No. 30 ( 2018-10)

Abstract: Flexible lithium‐ion batteries attract extensive attention in wearable electronics but are limited by severe capacity loss under extreme weather due to the poor flexible current collector. Herein, a horizontally oriented carbon nanotube macrofilm (HUCNM) with excellent electrical conductivity and tuned electrolyte wettability through engineering the surface/interface of HUCNM is reported for foldable batteries, which exhibits a high capacity of 700 mAh with excellent flexibility and stable charge/discharge rate performance in several extreme conditions. Such amazing results are ascribed to the excellent contact and interaction among the current collector, active material, and electrolyte, which is rising from the surface/interface engineering of carbon nanotube films. This work provides useful insights in the engineering of the surface/interface of carbon current collectors, and revolutionizes the traditional design for wearable electronics, transcending these devices beyond their current limitations.

Type of Medium: Online Resource

ISSN: 1614-6832 , 1614-6840

URL: Issue

URL: Article

DOI: 10.1002/aenm.v8.30

DOI: 10.1002/aenm.201802349

Language: English

Publisher: Wiley

Publication Date: 2018

detail.hit.zdb_id: 2594556-7

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Identification of Essential Residues of Human α- l -Fucosidase and Tests of Its Mechanism

Liu, Sheng-Wen ; Chen, Chao-Sheng ; Chang, Shih-Shen ; [et al.]

American Chemical Society (ACS) ; 2009

In: Biochemistry Vol. 48, No. 1 ( 2009-01-13), p. 110-120

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In: Biochemistry, American Chemical Society (ACS), Vol. 48, No. 1 ( 2009-01-13), p. 110-120

Type of Medium: Online Resource

ISSN: 0006-2960 , 1520-4995

URL: Article

DOI: 10.1021/bi801529t

RVK:

WA 15000

Language: English

Publisher: American Chemical Society (ACS)

Publication Date: 2009

detail.hit.zdb_id: 1472258-6

SSG: 12

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New Metabolites from the Endophytic Fungus Mollisia sp.

Fan, Nai Wen ; Chang, Hsun Shuo ; Cheng, Ming Jen ; [et al.]

Springer Science and Business Media LLC ; 2016

In: Chemistry of Natural Compounds Vol. 52, No. 4 ( 2016-7), p. 585-590

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In: Chemistry of Natural Compounds, Springer Science and Business Media LLC, Vol. 52, No. 4 ( 2016-7), p. 585-590

Type of Medium: Online Resource

ISSN: 0009-3130 , 1573-8388

URL: Article

DOI: 10.1007/s10600-016-1718-0

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2016

detail.hit.zdb_id: 2037133-0

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Genome-Wide Pharmacogenomic Study on Methadone Maintenance Treatment Identifies SNP rs17180299 and Multiple Haplotypes on CYP2B6, SPON1, and GSG1L Associated with Plasma Concentrations of Methadone R- and S-enantiomers in Heroin-Dependent Patients

Yang, Hsin-Chou ; Chu, Shih-Kai ; Huang, Chieh-Liang ; [et al.]

Public Library of Science (PLoS) ; 2016

In: PLOS Genetics Vol. 12, No. 3 ( 2016-3-24), p. e1005910-

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In: PLOS Genetics, Public Library of Science (PLoS), Vol. 12, No. 3 ( 2016-3-24), p. e1005910-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1005910

DOI: 10.1371/journal.pgen.1005910.g001

DOI: 10.1371/journal.pgen.1005910.g002

DOI: 10.1371/journal.pgen.1005910.g003

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DOI: 10.1371/journal.pgen.1005910.g005

DOI: 10.1371/journal.pgen.1005910.g006

DOI: 10.1371/journal.pgen.1005910.t001

DOI: 10.1371/journal.pgen.1005910.t002

DOI: 10.1371/journal.pgen.1005910.t003

DOI: 10.1371/journal.pgen.1005910.t004

DOI: 10.1371/journal.pgen.1005910.s001

DOI: 10.1371/journal.pgen.1005910.s002

DOI: 10.1371/journal.pgen.1005910.s003

DOI: 10.1371/journal.pgen.1005910.s004

DOI: 10.1371/journal.pgen.1005910.s005

DOI: 10.1371/journal.pgen.1005910.s006

DOI: 10.1371/journal.pgen.1005910.s007

DOI: 10.1371/journal.pgen.1005910.s008

DOI: 10.1371/journal.pgen.1005910.s009

DOI: 10.1371/journal.pgen.1005910.s010

DOI: 10.1371/journal.pgen.1005910.s011

DOI: 10.1371/journal.pgen.1005910.s012

DOI: 10.1371/journal.pgen.1005910.s013

DOI: 10.1371/journal.pgen.1005910.s014

DOI: 10.1371/journal.pgen.1005910.s015

DOI: 10.1371/journal.pgen.1005910.s016

DOI: 10.1371/journal.pgen.1005910.s017

DOI: 10.1371/journal.pgen.1005910.s018

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2016

detail.hit.zdb_id: 2186725-2

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TH Wildau

FH Potsdam

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