In:
Annual Review of Pharmacology and Toxicology, Annual Reviews, Vol. 40, No. 1 ( 2000-04), p. 389-430
Abstract:
Cloning of multiple opioid receptors has presented opportunities to investigate the mechanisms of multiple opioid receptor signaling and the regulation of these signals. The subsequent identification of receptor gene structures has also provided opportunities to study the regulation of receptor gene expression and to manipulate the concentration of the gene products in vivo. Thus, in the current review, we examine recent advances in the delineation basis for the multiple opioid receptor signaling, and their regulation at multiple levels. We discuss the use of receptor knockout animals to investigate the function and the pharmacology of these multiple opioid receptors. The reasons and basis for the multiple opioid receptor are addressed.
Type of Medium:
Online Resource
ISSN:
0362-1642
,
1545-4304
DOI:
10.1146/pharmtox.2000.40.issue-1
DOI:
10.1146/annurev.pharmtox.40.1.389
Language:
English
Publisher:
Annual Reviews
Publication Date:
2000
detail.hit.zdb_id:
1474461-2
SSG:
15,3
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