In:
Evidence-Based Complementary and Alternative Medicine, Hindawi Limited, Vol. 2015 ( 2015), p. 1-9
Abstract:
The rhizome of Smilax glabra has been used for a long time as both food and folk medicine in many countries. The present study focused on the active constituents from the rhizome of S. glabra , which possess potential anti-inflammatory activities. As a result, nine known compounds were isolated from the rhizome of S. glabra with the bioassay-guiding, and were identified as syringaresinol ( 1 ), lasiodiplodin ( 2 ), de-O-methyllasiodiplodin ( 3 ), syringic acid ( 4 ), 1,4-bis(4-hydroxy-3,5-dimethoxyphenyl)-2,3-bis(hydroxymethyl)-1,4-butanediol ( 5 ), lyoniresinol ( 6 ), trans -resveratrol ( 7 ), trans -caffeic acid methyl ester ( 8 ), and dihydrokaempferol ( 9 ). Among these compounds, 2 and 3 were isolated for the first time from S. glabra . In addition, the potential anti-inflammatory activities of the isolated compounds were evaluated in vitro in lipopolysaccharide- (LPS-) induced RAW264.7 cells. Results indicated that 4 and 7 showed significant inhibitory effects on NO production of RAW264.7 cells, and 1 , 2 , 3 , and 5 showed moderate suppression effects on induced NO production. 1 , 7 , and 5 exhibited high inhibitory effects on TNF- α production, with the IC 50 values less than 2.3, 4.4, and 16.6 μ M, respectively. These findings strongly suggest that compounds 1 , 2 , 3 , 4 , 5 , 7 , and 9 were the potential anti-inflammatory active compositions of S. glabra .
Type of Medium:
Online Resource
ISSN:
1741-427X
,
1741-4288
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2015
detail.hit.zdb_id:
2148302-4
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