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  • 1
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    Sleep complaints in early pregnancy. A cross-sectional study among women attending prenatal care in general practice
    Springer Science and Business Media LLC ; 2020
    In:  BMC Pregnancy and Childbirth Vol. 20, No. 1 ( 2020-12)
    Details
    In: BMC Pregnancy and Childbirth, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)
    Abstract: Sleep problems in late pregnancy are common, but sleep in early pregnancy is less well described. The aim of this study was to describe the occurrence and severity of sleep complaints in early pregnancy. We asked the women about worries due to sleep problems. Furthermore, we investigated the associations between sleep complaints and pregnancy-related symptoms. This association was studied taking into account physical and mental health, sociodemographic characteristics, and reproductive history of the women. Methods Cross-sectional study in Danish general practice based on an electronic questionnaire completed by pregnant women and a Pregnancy Health Record filled in by the general practitioner (GP). The questionnaire measured three sleep complaints and 11 common physical pregnancy-related symptoms. The sleep complaints were measured as mild, moderate or severe, and it was recorded how much they worried the women. The associations between the physical pregnancy-related symptoms and sleep complaints were assessed by odds ratios from multivariable logistic regression models. Results The questionnaire was completed by 1338 out of 1508 eligible women before the end of gestation week 16. The gestational age ranged from 5 to 16 weeks (median 11 weeks) among the included women. On average, more than one third of the women reported to have at least one of the three sleep complaints in the questionnaire. Problems “taking a long time to fall asleep” was reported by 312 women (23%), “waking up too early” was reported by 629 (47%), and 183 (14%) had been “lying awake most of the night”. One sleep complaint was reported by 38%, two by 16, and 4% had all three symptoms. The majority were not at all or only mildly worried because of their sleep disturbances, but moderate or severe worries were found among 46% of those“ taking a long time to fall asleep” and among 40% of those “lying awake most of the night”. “Moderate or severe complaints” were reported by 277 (21%) women “Moderate or severe complaints” were associated with pregnancy-related physical symptoms, such as back pain, pelvic girdle pain and pelvic cavity pain, but only the association with pelvic cavity pain stayed significant after adjustment for depression. Conclusion This study showed that sleep complaints in early pregnancy are common, and sleep complaints showed association with physical as well as mental symptoms. It may be important for pregnant patients that clinicians address depression, and mood in relation to sleep problems during pregnancy.
    Type of Medium: Online Resource
    ISSN: 1471-2393
    URL: Article
    DOI: 10.1186/s12884-020-2813-6
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2020
    detail.hit.zdb_id: 2059869-5
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  • 2
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    Expression of the Homeobox Genes OTX2 and OTX1 in the Early Developing Human Brain
    SAGE Publications ; 2010
    In:  Journal of Histochemistry & Cytochemistry Vol. 58, No. 7 ( 2010-07), p. 669-678
    Details
    In: Journal of Histochemistry & Cytochemistry, SAGE Publications, Vol. 58, No. 7 ( 2010-07), p. 669-678
    Abstract: In rodents, the Otx2 gene is expressed in the diencephalon, mesencephalon, and cerebellum and is crucial for the development of these brain regions. Together with Otx1, Otx2 is known to cooperate with other genes to develop the caudal forebrain and, further, Otx1 is also involved in differentiation of young neurons of the deeper cortical layers. We have studied the spatial and temporal expression of the two homeobox genes OTX2 and OTX1 in human fetal brains from 7 to 14 weeks postconception by in situ hybridization and immunohistochemistry. OTX2 was expressed in the diencephalon, mesencephalon, and choroid plexus, with a minor expression in the basal telencephalon. The expression of OTX2 in the hippocampal anlage was strong, with no expression in the adjacent neocortex. Contrarily, the OTX1 expression was predominantly located in the proliferative zones of the neocortex. At later stages, the OTX2 protein was found in the subcommissural organ, pineal gland, and cerebellum. The early expression of OTX2 and OTX1 in proliferative cell layers of the human fetal brain supports the concept that these homeobox genes are important in neuronal cell development and differentiation: OTX1 primarily in the neocortex, and OTX2 in the archicortex, diencephalon, rostral brain stem, and cerebellum.
    Type of Medium: Online Resource
    ISSN: 0022-1554 , 1551-5044
    URL: Article
    DOI: 10.1369/jhc.2010.955757
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2010
    detail.hit.zdb_id: 1421306-0
    SSG: 12
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  • 3
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    Physical discomfort in early pregnancy and postpartum depressive symptoms
    Informa UK Limited ; 2019
    In:  Nordic Journal of Psychiatry Vol. 73, No. 3 ( 2019-04-03), p. 200-206
    Details
    In: Nordic Journal of Psychiatry, Informa UK Limited, Vol. 73, No. 3 ( 2019-04-03), p. 200-206
    Type of Medium: Online Resource
    ISSN: 0803-9488 , 1502-4725
    URL: Article
    DOI: 10.1080/08039488.2019.1579861
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2019
    detail.hit.zdb_id: 2008313-0
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  • 4
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    Selection bias in general practice research: analysis in a cohort of pregnant Danish women
    Informa UK Limited ; 2020
    In:  Scandinavian Journal of Primary Health Care Vol. 38, No. 4 ( 2020-10-01), p. 464-472
    Details
    In: Scandinavian Journal of Primary Health Care, Informa UK Limited, Vol. 38, No. 4 ( 2020-10-01), p. 464-472
    Type of Medium: Online Resource
    ISSN: 0281-3432 , 1502-7724
    URL: Article
    DOI: 10.1080/02813432.2020.1847827
    Language: English
    Publisher: Informa UK Limited
    Publication Date: 2020
    detail.hit.zdb_id: 2027113-X
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  • 5
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    What factors are most important for the development of the maternal–fetal relationship? A prospective study among pregnant women in Danish general practice
    Springer Science and Business Media LLC ; 2021
    In:  BMC Psychology Vol. 9, No. 1 ( 2021-12)
    Details
    In: BMC Psychology, Springer Science and Business Media LLC, Vol. 9, No. 1 ( 2021-12)
    Abstract: Development of the maternal antenatal attachment (MAA) constitutes an important aspect of the transition into motherhood. Early identification of women at risk of developing a poor MAA provides possibilities for preventive interventions targeting maternal mental health and the emerging mother-infant relationship. In this study, we investigate the relative importance of an extensive set of psychosocial, pregnancy-related, and physiological factors measured in the first trimester of pregnancy for MAA measured in third trimester. Methods A prospective study was conducted among pregnant women in Danish general practice (GP). Data were obtained in the first and the third trimester from pregnancy health records and electronic questionnaires associated with routine GP antenatal care visits. The Maternal Antenatal Attachment Scale (MAAS) was used to assess maternal antenatal attachment. The relative importance of potential determinants of maternal antenatal attachment was assessed by the relative contribution of each factor to the fit (R 2 ) calculated from multivariable regression models. Results The sample consisted of 1328 women. Low antenatal attachment (Total MAAS ≤ 75) was observed for 513 (38.6%) women. Perceived social support (having someone to talk to and having access to practical help when needed) emerged as the most important determinant. Furthermore, scores on the MAAS decreased with worse self-rated health, poor physical fitness, depression, increasing age, having given birth previously, and higher education. Conclusion Pregnant women reporting lack of social support and general low physical and mental well-being early in pregnancy may be at risk for developing a poor MAA. An approach targeting both psychosocial and physiological well-being may positively influence expectant mothers’ successful adaptation to motherhood.
    Type of Medium: Online Resource
    ISSN: 2050-7283
    URL: Article
    DOI: 10.1186/s40359-020-00499-x
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2705921-2
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  • 6
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    Examining to what extent pregnancy-related physical symptoms worry women in the first trimester of pregnancy: a cross-sectional study in general practice
    Royal College of General Practitioners ; 2019
    In:  BJGP Open Vol. 3, No. 4 ( 2019-12), p. bjgpopen19X101674-
    Details
    In: BJGP Open, Royal College of General Practitioners, Vol. 3, No. 4 ( 2019-12), p. bjgpopen19X101674-
    Abstract: Women often wish to discuss their pregnancy symptoms with their GP. However, the two parties’ understanding of symptoms may not be aligned. Aim To examine to what degree a specific pregnancy-related symptom worried women in the first trimester and analyse the characteristics of the most worried women. Design & setting A cross-sectional study was performed in general practice in Denmark from 1 March 2015–15 August 2016. Method Women attending the first prenatal care visit completed a questionnaire about pregnancy-related physical symptoms and worries. Women were recruited from 125 GP practices and 294 GPs participated in the study. Further data were obtained from their pregnancy health record. Multivariable logistic regression analysis was used to assess the associations between the women’s worries and the severity of the symptoms, which were adjusted for age and parity. Results A total of 1508 women, aged 16–45 years, were included and 1455 completed the questionnaire. Nausea, vomiting, pelvic cavity pain, and back pain were the most common symptoms, and 88% reported having two or more symptoms simultaneously. Among the 1278 women reporting nausea, only 21% were worried, while 88% of the 252 women reporting vaginal bleeding were worried. Primigravidae (those pregnant for the first time) were significantly more worried about vomiting and nausea than multigravidae (those who have experienced pregnancy previously). Those aged 〉 35 years were more worried about pelvic girdle pain and pelvic cavity pain than younger women. Conclusion Pregnancy-related physical symptoms are frequent in the first trimester. The severity of worries depends on the symptom. Vaginal bleeding and pain give rise to the majority of severe worries, especially among young women.
    Type of Medium: Online Resource
    ISSN: 2398-3795
    URL: Article
    DOI: 10.3399/bjgpopen19X101674
    Language: English
    Publisher: Royal College of General Practitioners
    Publication Date: 2019
    detail.hit.zdb_id: 2881009-0
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  • 7
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    Factors in early pregnancy predicting pregnancy‐related pain in the second and third trimester
    Wiley ; 2023
    In:  Acta Obstetricia et Gynecologica Scandinavica Vol. 102, No. 10 ( 2023-10), p. 1269-1280
    Details
    In: Acta Obstetricia et Gynecologica Scandinavica, Wiley, Vol. 102, No. 10 ( 2023-10), p. 1269-1280
    Abstract: Pain during pregnancy affects women's well‐being, causes worry and is a risk factor for the child and the mother during labor. The aim was to investigate the relative importance of an extensive set of pregnancy‐related physiological symptoms and psychosocial factors assessed in the first trimester compared with the occurrence of pregnancy‐related pain symptoms later in the pregnancy. Material and methods Included were all women who booked an appointment for a first prenatal visit in one of 125 randomly selected general practitioner practices in Eastern Denmark from April 2015 to August 2016. These women answered an electronic questionnaire containing questions on the occurrence of five pregnancy‐related pain symptoms: back pain, leg cramps, pelvic cavity pain, pelvic girdle pain and uterine contractions. The questionnaire also included sociodemographic questions and questions on chronic diseases, physical symptoms, mental health symptoms, lifestyle and reproductive background. The questionnaire was repeated in each trimester. The relative importance of this set of factors from the first trimester on the five pregnancy‐related pain symptoms compared with the second and third trimesters was assessed in a dominance analysis. Results A total of 1491 women were included. The most important factor for pregnancy‐related pain in the second trimester and third trimester is the presence of the corresponding pain in the first trimester. Parity was associated with pelvic cavity pain and uterine contractions in the following pregnancies. For back pain and pelvic cavity pain, the odds increased as the women's estimated low self‐assessed fitness decreased and had low WHO‐5 wellbeing scores. Conclusions When including physical risk factors, sociodemographic factors, psychological factors and clinical risk factors, women's experiences of pregnancy‐related pain in the first trimester are the most important predictors for pain later in pregnancy. Beyond the expected positive effects of pregnancy‐related pain, notably self‐assessed fitness, age and parity were predictive for pain later in pregnancy.
    Type of Medium: Online Resource
    ISSN: 0001-6349 , 1600-0412
    URL: Issue
    URL: Article
    DOI: 10.1111/aogs.v102.10
    DOI: 10.1111/aogs.14670
    RVK:
    YM 6500
    Language: English
    Publisher: Wiley
    Publication Date: 2023
    detail.hit.zdb_id: 2024554-3
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  • 8
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    Spatiotemporal Distribution of 〈i〉PAX6〈/i〉 and 〈i〉MEIS2〈/i〉 Expression and Total Cell Numbers in the Ganglionic Eminence in the Early Developing Human Forebrain
    S. Karger AG ; 2010
    In:  Developmental Neuroscience Vol. 32, No. 2 ( 2010), p. 149-162
    Details
    In: Developmental Neuroscience, S. Karger AG, Vol. 32, No. 2 ( 2010), p. 149-162
    Abstract: The development of the human neocortex is a complex and highly regulated process involving a time-related expression of many transcription factors including the homeobox genes 〈 i 〉 Pax6 〈 /i 〉 and 〈 i 〉 Meis2 〈 /i 〉 . During early development, 〈 i 〉 Pax6 〈 /i 〉 is expressed in nuclei of radial glia cells in the neocortical proliferative zones and controls the differentiation and neurogenetic fate of these cells in the dorsal telencephalon in rodents. Animal studies on the 〈 i 〉 Meis2 〈 /i 〉 gene have revealed expression in the developing telencephalon and 〈 i 〉 Meis2 〈 /i 〉 is known to regulate the expression of 〈 i 〉 Pax6 〈 /i 〉 in the eye and pancreas. Because of this functional relation between 〈 i 〉 Pax6 〈 /i 〉 and 〈 i 〉 Meis2 〈 /i 〉 , we studied the spatial and temporal expression of 〈 i 〉 PAX6 〈 /i 〉 , and 〈 i 〉 MEIS2 〈 /i 〉 using a developmental series of human fetal brains at 7–19 postconceptional weeks with emphasis on the forebrain to investigate whether the two genes are expressed in the same regions and zones in the same time window. We demonstrate by in situ hybridization and immunohistochemistry that the two homeobox genes are expressed during early fetal brain development in humans. PAX6 mRNA and protein were located in the proliferative zones of the neocortex and in single cells in the cortical preplate at 7 fetal weeks and in the developing cortical plate from 8 or 9 to 19 fetal weeks. The expression of 〈 i 〉 PAX6 〈 /i 〉 expanded into the ganglionic eminence just prior to the stage at which a stereological estimation showed an exponential rise in total cell number in this area. The 〈 i 〉 MEIS2 〈 /i 〉 gene was also present in the proliferative zones of the human fetal neocortex and a higher expression of 〈 i 〉 MEIS2 〈 /i 〉 than 〈 i 〉 PAX6 〈 /i 〉 was observed in these areas at 9 fetal weeks. Further, 〈 i 〉 MEIS2 〈 /i 〉 was expressed at a very high level in the developing ganglionic eminence and at a more moderate level in the cortical plate.
    Type of Medium: Online Resource
    ISSN: 0378-5866 , 1421-9859
    URL: Article
    DOI: 10.1159/000297602
    RVK:
    XG 8817
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482201-5
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  • 9
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    Tricyclic Imidazoline Derivatives as Potent and Selective Adenosine A1 Receptor Antagonists
    American Chemical Society (ACS) ; 2006
    In:  Journal of Medicinal Chemistry Vol. 49, No. 24 ( 2006-11-30), p. 7132-7139
    Details
    In: Journal of Medicinal Chemistry, American Chemical Society (ACS), Vol. 49, No. 24 ( 2006-11-30), p. 7132-7139
    Type of Medium: Online Resource
    ISSN: 0022-2623 , 1520-4804
    URL: Article
    URL: Article
    DOI: 10.1021/jm060539t
    DOI: 10.1021/jm060539t.s001
    Language: English
    Publisher: American Chemical Society (ACS)
    Publication Date: 2006
    detail.hit.zdb_id: 1491411-6
    SSG: 15,3
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