In:
PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 10 ( 2021-10-6), p. e1009742-
Abstract:
Disease manifestations in COVID-19 range from mild to severe illness associated with a dysregulated innate immune response. Alterations in function and regeneration of dendritic cells (DCs) and monocytes may contribute to immunopathology and influence adaptive immune responses in COVID-19 patients. We analyzed circulating DC and monocyte subsets in 65 hospitalized COVID-19 patients with mild/moderate or severe disease from acute illness to recovery and in healthy controls. Persisting reduction of all DC subpopulations was accompanied by an expansion of proliferating Lineage − HLADR + cells lacking DC markers. Increased frequency of CD163 + CD14 + cells within the recently discovered DC3 subpopulation in patients with more severe disease was associated with systemic inflammation, activated T follicular helper cells, and antibody-secreting cells. Persistent downregulation of CD86 and upregulation of programmed death-ligand 1 (PD-L1) in conventional DCs (cDC2 and DC3) and classical monocytes associated with a reduced capacity to stimulate naïve CD4 + T cells correlated with disease severity. Long-lasting depletion and functional impairment of DCs and monocytes may have consequences for susceptibility to secondary infections and therapy of COVID-19 patients.
Type of Medium:
Online Resource
ISSN:
1553-7374
DOI:
10.1371/journal.ppat.1009742
DOI:
10.1371/journal.ppat.1009742.g001
DOI:
10.1371/journal.ppat.1009742.g002
DOI:
10.1371/journal.ppat.1009742.g003
DOI:
10.1371/journal.ppat.1009742.g004
DOI:
10.1371/journal.ppat.1009742.g005
DOI:
10.1371/journal.ppat.1009742.g006
DOI:
10.1371/journal.ppat.1009742.g007
DOI:
10.1371/journal.ppat.1009742.g008
DOI:
10.1371/journal.ppat.1009742.s001
DOI:
10.1371/journal.ppat.1009742.s002
DOI:
10.1371/journal.ppat.1009742.s003
DOI:
10.1371/journal.ppat.1009742.s004
DOI:
10.1371/journal.ppat.1009742.s005
DOI:
10.1371/journal.ppat.1009742.s006
DOI:
10.1371/journal.ppat.1009742.s007
DOI:
10.1371/journal.ppat.1009742.s008
DOI:
10.1371/journal.ppat.1009742.s009
DOI:
10.1371/journal.ppat.1009742.s010
DOI:
10.1371/journal.ppat.1009742.s011
DOI:
10.1371/journal.ppat.1009742.s012
DOI:
10.1371/journal.ppat.1009742.s013
DOI:
10.1371/journal.ppat.1009742.s014
DOI:
10.1371/journal.ppat.1009742.s015
DOI:
10.1371/journal.ppat.1009742.r001
DOI:
10.1371/journal.ppat.1009742.r002
DOI:
10.1371/journal.ppat.1009742.r003
DOI:
10.1371/journal.ppat.1009742.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2205412-1
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