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m4C DNA methylation regulates biosynthesis of daptomycin in Streptomyces roseosporus L30

Fang, Jiao-Le ; Gao, Wen-Li ; Xu, Wei-Feng ; [et al.]

Elsevier BV ; 2022

In: Synthetic and Systems Biotechnology Vol. 7, No. 4 ( 2022-12), p. 1013-1023

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In: Synthetic and Systems Biotechnology, Elsevier BV, Vol. 7, No. 4 ( 2022-12), p. 1013-1023

Type of Medium: Online Resource

ISSN: 2405-805X

URL: Article

DOI: 10.1016/j.synbio.2022.06.001

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2846506-4

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A novel strategy of gene screen based on multi-omics in Streptomyces roseosporus

Xu, Wei-Feng ; Fang, Jiao-Le ; Bu, Qing-Ting ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Applied Microbiology and Biotechnology Vol. 106, No. 8 ( 2022-04), p. 3103-3112

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In: Applied Microbiology and Biotechnology, Springer Science and Business Media LLC, Vol. 106, No. 8 ( 2022-04), p. 3103-3112

Type of Medium: Online Resource

ISSN: 0175-7598 , 1432-0614

URL: Article

DOI: 10.1007/s00253-022-11904-3

RVK:

WA 15000

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 1464336-4

SSG: 12

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Comparing the morphological characteristics and nutritional composition of 23 pepper (Capsicum annuum L.) varieties

Jin, Li ; Jin, Ning ; Wang, Shuya ; [et al.]

Springer Science and Business Media LLC ; 2023

In: European Food Research and Technology Vol. 249, No. 4 ( 2023-04), p. 963-974

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In: European Food Research and Technology, Springer Science and Business Media LLC, Vol. 249, No. 4 ( 2023-04), p. 963-974

Type of Medium: Online Resource

ISSN: 1438-2377 , 1438-2385

URL: Article

DOI: 10.1007/s00217-022-04187-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 1476605-X

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Table_4.DOCX

Lyu, Zhong-Yuan ; Bu, Qing-Ting ; Fang, Jiao-Le ; [et al.]

Frontiers Media SA ; 2022

In: Frontiers in Microbiology Vol. 13 ( 2022-4-18)

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In: Frontiers in Microbiology, Frontiers Media SA, Vol. 13 ( 2022-4-18)

Abstract: Daptomycin is a cyclic lipopeptide antibiotic with a significant antibacterial action against antibiotic-resistant Gram-positive bacteria. Despite numerous attempts to enhance daptomycin yield throughout the years, the production remains unsatisfactory. This study reports the application of multilevel metabolic engineering strategies in Streptomyces roseosporus to reconstruct high-quality daptomycin overproducing strain L2797-VHb, including precursor engineering (i.e., refactoring kynurenine pathway), regulatory pathway reconstruction (i.e., knocking out negative regulatory genes arpA and phaR ), byproduct engineering (i.e., removing pigment), multicopy biosynthetic gene cluster (BGC), and fermentation process engineering (i.e., enhancing O 2 supply). The daptomycin titer of L2797-VHb arrived at 113 mg/l with 565% higher comparing the starting strain L2790 (17 mg/l) in shake flasks and was further increased to 786 mg/l in 15 L fermenter. This multilevel metabolic engineering method not only effectively increases daptomycin production, but can also be applied to enhance antibiotic production in other industrial strains.

Type of Medium: Online Resource

ISSN: 1664-302X

URL: Article

DOI: 10.3389/fmicb.2022.872397

DOI: 10.3389/fmicb.2022.872397.s001

DOI: 10.3389/fmicb.2022.872397.s002

DOI: 10.3389/fmicb.2022.872397.s003

DOI: 10.3389/fmicb.2022.872397.s004

DOI: 10.3389/fmicb.2022.872397.s005

DOI: 10.3389/fmicb.2022.872397.s006

DOI: 10.3389/fmicb.2022.872397.s007

DOI: 10.3389/fmicb.2022.872397.s008

DOI: 10.3389/fmicb.2022.872397.s009

DOI: 10.3389/fmicb.2022.872397.s010

DOI: 10.3389/fmicb.2022.872397.s011

DOI: 10.3389/fmicb.2022.872397.s012

DOI: 10.3389/fmicb.2022.872397.s013

Language: Unknown

Publisher: Frontiers Media SA

Publication Date: 2022

detail.hit.zdb_id: 2587354-4

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Developing high elongation of Ca-containing Zn alloys with superior osteogenic and antibacterial properties

Xiao, Yong ; Cai, Yu ; Yao, Wenmin ; [et al.]

Elsevier BV ; 2024

In: Journal of Alloys and Compounds ( 2024-10), p. 176988-

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In: Journal of Alloys and Compounds, Elsevier BV, ( 2024-10), p. 176988-

Type of Medium: Online Resource

ISSN: 0925-8388

URL: Article

DOI: 10.1016/j.jallcom.2024.176988

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 2012675-X

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Identification and Characterization of a New Regulator, TagR, for Environmental Stress Resistance Based on the DNA Methylome of Streptomyces roseosporus

Gao, Wen-Li ; Fang, Jiao-Le ; Zhu, Chen-Yang ; [et al.]

American Society for Microbiology ; 2023

In: Microbiology Spectrum Vol. 11, No. 3 ( 2023-06-15)

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In: Microbiology Spectrum, American Society for Microbiology, Vol. 11, No. 3 ( 2023-06-15)

Abstract: DNA methylation is a defense that microorganisms use against extreme environmental stress, and improving resistance against environmental stress is essential for industrial actinomycetes. However, research on strain optimization utilizing DNA methylation for breakthroughs is rare. Based on DNA methylome analysis and KEGG pathway assignment in Streptomyces roseosporus , we discovered an environmental stress resistance regulator, TagR. A series of in vivo and in vitro experiments identified TagR as a negative regulator, and it is the first reported regulator of the wall teichoic acid (WTA) ABC transport system. Further study showed that TagR had a positive self-regulatory loop and m4C methylation in the promoter improved its expression. The Δ tagR mutant exhibited better hyperosmotic resistance and higher decanoic acid tolerance than the wild type, which led to a 100% increase in the yield of daptomycin. Moreover, enhancing the expression of the WTA transporter resulted in better osmotic stress resistance in Streptomyces lividans TK24, indicating the potential for wide application of the TagR-WTA transporter regulatory pathway. This research confirmed the feasibility and effectiveness of mining regulators of environmental stress resistance based on the DNA methylome, characterized the mechanism of TagR, and improved the resistance and daptomycin yield of strains. Furthermore, this research provides a new perspective on the optimization of industrial actinomycetes. IMPORTANCE This study established a novel strategy for screening regulators of environmental stress resistance based on the DNA methylome and discovered a new regulator, TagR. The TagR-WTA transporter regulatory pathway improved the resistance and antibiotic yield of strains and has the potential for wide application. Our research provides a new perspective on the optimization and reconstruction of industrial actinomycetes.

Type of Medium: Online Resource

ISSN: 2165-0497

URL: Article

DOI: 10.1128/spectrum.00380-23

Language: English

Publisher: American Society for Microbiology

Publication Date: 2023

detail.hit.zdb_id: 2807133-5

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Controllable Synthesis of Ag-In-Zn-S Quaternary Nanocrystals and Their Applications in Electroluminescent Light-emitting Diodes

ZHANG, Jing ; 北京交通大学　理学院，北京　 100044 School of Science, Beijing Jiaotong University, Beijing 100044, China ; LYU, Pei-wen ; [et al.]

Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences ; 2021

In: Chinese Journal of Luminescence Vol. 42, No. 05 ( 2021), p. 620-628

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In: Chinese Journal of Luminescence, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Vol. 42, No. 05 ( 2021), p. 620-628

Type of Medium: Online Resource

ISSN: 1000-7032

URL: Article

DOI: 10.37188/CJL.20210016

Language: English

Publisher: Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences

Publication Date: 2021

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Sequence sedimentary evolution and reservoir distribution in the third and fourth members of Sinian Dengying Formation, Gaomo area, Sichuan Basin, SW China

TAN, Lei ; LIU, Hong ; CHEN, Kang ; [et al.]

Elsevier BV ; 2022

In: Petroleum Exploration and Development Vol. 49, No. 5 ( 2022-10), p. 1004-1018

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In: Petroleum Exploration and Development, Elsevier BV, Vol. 49, No. 5 ( 2022-10), p. 1004-1018

Type of Medium: Online Resource

ISSN: 1876-3804

URL: Article

DOI: 10.1016/S1876-3804(22)60328-8

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2471051-9

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Anthracene and porphyrin-based conjugated microporous polymer for nitrofuran antibiotics and nitroaromatic explosives detection

Qi, Chufeng ; Liu, Huiling ; Lyu, Jiatong ; [et al.]

Elsevier BV ; 2023

In: Journal of Environmental Chemical Engineering Vol. 11, No. 6 ( 2023-12), p. 111553-

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In: Journal of Environmental Chemical Engineering, Elsevier BV, Vol. 11, No. 6 ( 2023-12), p. 111553-

Type of Medium: Online Resource

ISSN: 2213-3437

URL: Article

DOI: 10.1016/j.jece.2023.111553

Language: English

Publisher: Elsevier BV

Publication Date: 2023

detail.hit.zdb_id: 2710047-9

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Figure 8 from: Lyu J-C, Dai L-L, Wei P-F, He Y-H, Yuan Z-Y, Shi W-L, Zhou S-l, Ran S-y, Kuang Z-F, Guo X, Wei G, Yuan G (2020) A new species of the genus Leptobrachella Smith, 1925 (Anura, Megophryidae) from Guizhou, China. ZooKeys 1008: 139-157. https://doi.org/10.3897/zookeys.1008.56412

Lyu, Jing-Cai ; Dai, Liang-Liang ; Wei, Ping-Fan ; [et al.]

Pensoft Publishers ; 2020

In: ZooKeys Vol. 1008 ( 2020-12-31), p. 139-157

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In: ZooKeys, Pensoft Publishers, Vol. 1008 ( 2020-12-31), p. 139-157

Abstract: Asian leaf-litter toads of the genus Leptobrachella represent charismatic anuran diversification with 80 species, of which 25 are from China. Recent new discoveries suggest that the diversity of this genus is underestimated. Here, we describe a new species of Leptobrachella , Leptobrachella bashaensis sp. nov. from the Basha Nature Reserve, Congjiang County, Guizhou Province, China. The new species is distinguished from its congeners by the following suite of morphological traits: small body size (SVL 22.9–25.6 mm in six adult males and 27.1 mm in one adult female); head longer than wide; dorsal skin slightly shagreened with small tubercles; creamy-white chest and belly with irregular black spots; distinct ventrolateral glands forming a white line; finger webbing and fringes absent; toe webbing rudimentary and lateral fringes narrow; iris bicolored with bright orange in upper half and silver in lower half; dorsal surface of tadpole head dark brown with small, brown, irregular spot, air sac-shaped bulges on both sides of body. The new species differs from all known congeners by an uncorrected p -distance of & gt;5.3% of the 16S rRNA gene fragment examined, and the phylogenetic analysis clusters the new species with L. maoershanensis and L. laui . At present, the new species is only known from a small range of montane evergreen secondary forests in Basha Nature Reserve approximately 900 m elevation. Its natural history and conservation status are discussed.

Type of Medium: Online Resource

ISSN: 1313-2970 , 1313-2989

URL: Article

DOI: 10.3897/zookeys.1008.56412

DOI: 10.3897/zookeys.1008.56412.figure1

DOI: 10.3897/zookeys.1008.56412.figure2

DOI: 10.3897/zookeys.1008.56412.figure3

DOI: 10.3897/zookeys.1008.56412.figure4

DOI: 10.3897/zookeys.1008.56412.figure5

DOI: 10.3897/zookeys.1008.56412.figure6

DOI: 10.3897/zookeys.1008.56412.figure7

DOI: 10.3897/zookeys.1008.56412.figure8

Language: Unknown

Publisher: Pensoft Publishers

Publication Date: 2020

detail.hit.zdb_id: 2445640-8

SSG: 12

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