In:
ChemMedChem, Wiley, Vol. 4, No. 6 ( 2009-06-08), p. 886-886
Abstract:
The inside cover picture shows the X‐ray‐determined binding of an α‐ethoxy‐phenyl‐propionic acid‐derived dual PPARα/γ agonist in complex with PPARα (yellow) and PPARγ (blue). The high α‐selectivity of this phenylthiazole (IC 50 γ/α = 37; EC 50 γ/α = 7) can be rationalized mainly by a single residue difference, Cys 275 (α) vs. Gly 284 (γ), leading to three additional interactions with the terminal p ‐Cl‐Ph group. In addition, its binding site is highlighted in a surface representation of the PPARα protein. For more details, see the Communication by U. Grether et al. on p. 951 ff. magnified image
Type of Medium:
Online Resource
ISSN:
1860-7179
,
1860-7187
DOI:
10.1002/cmdc.200990027
Language:
English
Publisher:
Wiley
Publication Date:
2009
detail.hit.zdb_id:
2209649-8
SSG:
15,3
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