In:
Journal of the Science of Food and Agriculture, Wiley, Vol. 94, No. 5 ( 2014-03-30), p. 951-954
Abstract:
Viticultural residues from commercial viticultural activities represent a potentially important source of bioactive stilbenes such as resveratrol. The main aim of the present study was therefore to isolate, identify and perform biological assays against amyloid‐β peptide aggregation of original stilbenes from Vitis vinifera shoots. RESULTS A new resveratrol oligomer, ( Z )‐ cis ‐miyabenol C (3), was isolated from Vitis vinifera grapevine shoots together with two newly reported oligostilbenes from Vitis vinifera shoots, vitisinol C (1) and ( E )‐ cis ‐miyabenol C (2), and six known compounds: piceatannol, resveratrol, ( E )‐ ε ‐viniferin ( trans‐ε ‐viniferin), ω ‐viniferin, vitisinol C and ( E )‐miyabenol C. The structures of these resveratrol derivatives were established on the basis of detailed spectroscopic analysis including nuclear magnetic resonance experiments. All the newly reported compounds were tested for their anti‐aggregative activity against amyloid‐β fibril formation. Vitisinol C was found to exert a significant activity against amyloid‐β aggregation. CONCLUSION Vitis vinifera grapevine shoots are potentially interesting as a source of new bioactive stilbenes, such as vitisinol C. © 2013 Society of Chemical Industry
Type of Medium:
Online Resource
ISSN:
0022-5142
,
1097-0010
DOI:
10.1002/jsfa.2014.94.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2001807-1
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