In:
International Journal of Cancer, Wiley, Vol. 138, No. 4 ( 2016-02-15), p. 964-975
Abstract:
What's new? Tumor–stroma interactions play an essential role in colorectal carcinoma (CRC), with multipotent mesenchymal stromal cells (MSC) possibly representing a key part of the stroma. However, little is known about specific interactions between MSC and CRC cells with different mutational backgrounds. This study shows that MSC facilitates tumor formation in CRC cells with dysfunctional E‐cadherin in a mechanism dependent on CRC cell expressed β1‐integrin. MSC‐expressed extracellular matrix seems pivotal for this MSC–CRC interaction. In α‐catenin‐deficient CRC cells, β1‐integrin‐dependent interaction resulted in promotion of early tumor growth in vivo . The data show that MSC specifically interact with CRC cells of distinct mutational backgrounds.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2016
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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