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1

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Features and Outcomes of Histologically Proven Myocarditis With Fulminant Presentation

Kanaoka, Koshiro ; Onoue, Kenji ; Terasaki, Satoshi ; [et al.]

Ovid Technologies (Wolters Kluwer Health) ; 2022

In: Circulation Vol. 146, No. 19 ( 2022-11-08), p. 1425-1433

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In: Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 146, No. 19 ( 2022-11-08), p. 1425-1433

Abstract: Fulminant myocarditis presentation (FMP) is a rare and severe presentation of myocarditis. The natural history of FMP and its clinical features associated with poor outcomes are incompletely understood because there is a lack of generalizable evidence. Methods: This multicenter retrospective cohort study included patients hospitalized with histologically proven myocarditis who underwent catecholamine or mechanical support from 235 cardiovascular training hospitals across Japan between April 2012 and March 2017. Clinical features and the prognostic predictors of death or heart transplantation within 90 days on the basis of clinical and pathologic findings were determined using the Kaplan-Meier method, log-rank test, and Cox regression analysis. Results: This study included 344 patients with histologically proven FMP (median age, 54 years; 40% female). The median follow-up was 600 days (interquartile range, 36 to 1599 days) and the cumulative risk of death or heart transplantation at 90 days was 29% (n=98). Results from multivariable Cox regression analysis showed that older age, nonsinus rhythm, low left ventricular wall motion ( 〈 40%) on admission, and ventricular tachycardia or fibrillation on admission day were associated with worse 90-day survival. Severe histologic damage (damaged cardiomyocytes comprising ≥50% of the total cardiomyocytes) was associated with a worse 90-day prognosis in patients with lymphocytic myocarditis. Conclusions: The results from analyses of data from this multicenter registry demonstrated that patients with FMP are at a higher risk of death or heart transplantation in real-world settings. These observations inform which clinical and pathologic findings may be useful for prognostication in FMP. Registration: URL: https://www.umin.ac.jp/ctr ; Unique identifier: UMIN000039763.

Type of Medium: Online Resource

ISSN: 0009-7322 , 1524-4539

URL: Article

DOI: 10.1161/CIRCULATIONAHA.121.058869

Language: English

Publisher: Ovid Technologies (Wolters Kluwer Health)

Publication Date: 2022

detail.hit.zdb_id: 1466401-X

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2

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Microsatellite frameshift variants in SGO1 of gastric cancer are not always associated with MSI status

Sugiyama, Tomohiro ; Iwaizumi, Moriya ; Taniguchi, Terumi ; [et al.]

BMJ ; 2021

In: Journal of Clinical Pathology Vol. 74, No. 6 ( 2021-06), p. 386-390

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In: Journal of Clinical Pathology, BMJ, Vol. 74, No. 6 ( 2021-06), p. 386-390

Abstract: Although frameshift variants in the microsatellite area of shugoshin 1 ( SGO1 ) have been reported in the context of microsatellite instability-high (MSI-H)/deficient mismatch repair gastrointestinal cancer, most have been evaluated only in early stage I–III patients, and only two of its five microsatellite regions have been evaluated. Therefore, we investigated the frequency and MSI status of microsatellite frameshift variants in gastric cancer cases, including stage IV. Methods In a total of 55 cases, 30 gastric cancer resection and 25 non-resection cases, DNA was extracted from both tumour and normal parts and PCR was performed. The variant was confirmed by TA cloning, and MSI was evaluated using GeneMapper software. Results A frameshift variant of c.973delA was observed in 16 of the 45 evaluable cases. Its frequency was 35.6%. Of the 25 cases that could be assessed for MSI status, two cases of MSI-H were associated with the c.973delA SGO1 variant. However, c.973delA SGO1 variant was also observed in four cases of microsatellite stable. Conclusion Our study shows that SGO1 frameshift variants are not always associated with MSI status.

Type of Medium: Online Resource

ISSN: 0021-9746 , 1472-4146

URL: Article

DOI: 10.1136/jclinpath-2020-206934

RVK:

XA 10000

Language: English

Publisher: BMJ

Publication Date: 2021

detail.hit.zdb_id: 2028928-5

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3

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Hydrogel-based biomimetic environment for in vitro modulation of branching morphogenesis

Miyajima, Hiroyuki ; Matsumoto, Takuya ; Sakai, Takayoshi ; [et al.]

Elsevier BV ; 2011

In: Biomaterials Vol. 32, No. 28 ( 2011-10), p. 6754-6763

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In: Biomaterials, Elsevier BV, Vol. 32, No. 28 ( 2011-10), p. 6754-6763

Type of Medium: Online Resource

ISSN: 0142-9612

URL: Article

DOI: 10.1016/j.biomaterials.2011.05.072

Language: English

Publisher: Elsevier BV

Publication Date: 2011

detail.hit.zdb_id: 2004010-6

SSG: 12

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4

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An Autopsy Case of the Marburg Variant of Multiple Sclerosis (Acute Multiple Sclerosis)

Suzuki, Makiko ; Kawasaki, Hideya ; Masaki, Katsuhisa ; [et al.]

Japanese Society of Internal Medicine ; 2013

In: Internal Medicine Vol. 52, No. 16 ( 2013), p. 1825-1832

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In: Internal Medicine, Japanese Society of Internal Medicine, Vol. 52, No. 16 ( 2013), p. 1825-1832

Type of Medium: Online Resource

ISSN: 0918-2918 , 1349-7235

URL: Article

DOI: 10.2169/internalmedicine.52.0425

RVK:

XA 49642

Language: English

Publisher: Japanese Society of Internal Medicine

Publication Date: 2013

detail.hit.zdb_id: 2202453-0

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5

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Treatment Outcomes for Laparoscopic Interval Appendectomy (LIA) in the Treatment of Abscess-forming Appendicitis

Kobayashi, Shinjiro ; Ohshima, Ryuichi ; Katayama, Masafumi ; [et al.]

The Japanese Journal of Gastroenterological Surgery ; 2012

In: The Japanese Journal of Gastroenterological Surgery Vol. 45, No. 4 ( 2012), p. 353-358

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In: The Japanese Journal of Gastroenterological Surgery, The Japanese Journal of Gastroenterological Surgery, Vol. 45, No. 4 ( 2012), p. 353-358

Type of Medium: Online Resource

ISSN: 0386-9768 , 1348-9372

URL: Article

DOI: 10.5833/jjgs.45.353

Language: Unknown

Publisher: The Japanese Journal of Gastroenterological Surgery

Publication Date: 2012

detail.hit.zdb_id: 2303686-2

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6

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Prostaglandin E-major urinary metabolite versus fecal immunochemical occult blood test as a biomarker for patient with ulcerative colitis

Ishida, Natsuki ; Miyazu, Takahiro ; Takano, Ryosuke ; [et al.]

Springer Science and Business Media LLC ; 2020

In: BMC Gastroenterology Vol. 20, No. 1 ( 2020-12)

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In: BMC Gastroenterology, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2020-12)

Abstract: Prostaglandin E-major urinary metabolite (PGE-MUM) may be a novel biomarker for evaluating disease activity in ulcerative colitis (UC). We compared its usefulness to that of the fecal immunochemical occult blood test (FIT). Methods PGE-MUM and FIT measurements were performed of 92 urinary and fecal samples obtained from 60 patients with UC. Endoscopic activity was determined by Mayo endoscopic subscore (eMayo) and Ulcerative Colitis Endoscopic Index of Severity (UCEIS) score. Results PGE-MUM levels and FIT results showed a significant correlation with respect to eMayo ( P 〈 0.001 and P 〈 0.001, respectively), and there was a significant difference in PGE-MUM values between the groups below eMayo1 and above eMayo2 ( P = 0.012). Both biomarkers were significantly correlated with the UCEIS score ( P 〈 0.001 and P 〈 0.001, respectively), and the PGE-MUM values were significantly different between groups below UCEIS1 and above UCEIS2 ( P = 0.012). PGE-MUM and FIT were significantly correlated with eMayo in the group with a disease duration 〈 5 years ( P = 0.041 and P 〈 0.001, respectively). Although PGE-MUM and eMayo differed significantly between groups over 5 years ( P = 0.012), FIT was not correlated with eMayo ( P = 0.101). Conclusions PGE-MUM is useful as a biomarker as FIT for evaluating the endoscopic activity, particularly in long-term affected patients with UC.

Type of Medium: Online Resource

ISSN: 1471-230X

URL: Article

DOI: 10.1186/s12876-020-01256-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2020

detail.hit.zdb_id: 2041351-8

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7

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Immunological Study on Serum of Patients with Periodontal disease

TANI, Akira ; MORI, Shoichi ; HIDAKA, Satoshi ; [et al.]

Japanese Society of Periodontology ; 1977

In: Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology) Vol. 19, No. 1 ( 1977), p. 47-52

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In: Nihon Shishubyo Gakkai Kaishi (Journal of the Japanese Society of Periodontology), Japanese Society of Periodontology, Vol. 19, No. 1 ( 1977), p. 47-52

Type of Medium: Online Resource

ISSN: 0385-0110 , 1880-408X

Uniform Title: 歯周疾患患者血清の免疫学的研究

URL: Article

DOI: 10.2329/perio.19.47

Language: Japanese , Japanese

Publisher: Japanese Society of Periodontology

Publication Date: 1977

detail.hit.zdb_id: 2218241-X

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8

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Ramucirumab plus docetaxel versus placebo plus docetaxel in patients with locally advanced or metastatic urothelial carcinoma after platinum-based therapy (RANGE): overall survival and updated results of a randomised, double-blind, phase 3 trial

Petrylak, Daniel P ; de Wit, Ronald ; Chi, Kim N ; [et al.]

Elsevier BV ; 2020

In: The Lancet Oncology Vol. 21, No. 1 ( 2020-01), p. 105-120

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In: The Lancet Oncology, Elsevier BV, Vol. 21, No. 1 ( 2020-01), p. 105-120

Type of Medium: Online Resource

ISSN: 1470-2045

URL: Article

DOI: 10.1016/S1470-2045(19)30668-0

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 2049730-1

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9

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Tripartite Motif Protein 32 Facilitates Cell Growth and Migration via Degradation of Abl-Interactor 2

Kano, Satoshi ; Miyajima, Naoto ; Fukuda, Satoshi ; [et al.]

American Association for Cancer Research (AACR) ; 2008

In: Cancer Research Vol. 68, No. 14 ( 2008-07-15), p. 5572-5580

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In: Cancer Research, American Association for Cancer Research (AACR), Vol. 68, No. 14 ( 2008-07-15), p. 5572-5580

Abstract: Tripartite motif protein 32 (TRIM32) mRNA has been reported to be highly expressed in human head and neck squamous cell carcinoma, but the involvement of TRIM32 in carcinogenesis has not been fully elucidated. In this study, we found by using yeast two-hybrid screening that TRIM32 binds to Abl-interactor 2 (Abi2), which is known as a tumor suppressor and a cell migration inhibitor, and we showed that TRIM32 mediates the ubiquitination of Abi2. Overexpression of TRIM32 promoted degradation of Abi2, resulting in enhancement of cell growth, transforming activity, and cell motility, whereas a dominant-negative mutant of TRIM32 lacking the RING domain inhibited the degradation of Abi2. In addition, we found that TRIM32 suppresses apoptosis induced by cis-diamminedichloroplatinum (II) in HEp2 cell lines. These findings suggest that TRIM32 is a novel oncogene that promotes tumor growth, metastasis, and resistance to anticancer drugs. [Cancer Res 2008;68(14):5572–80]

Type of Medium: Online Resource

ISSN: 0008-5472 , 1538-7445

URL: Article

DOI: 10.1158/0008-5472.CAN-07-6231

RVK:

XA 36000

RVK:

XA 10000

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2008

detail.hit.zdb_id: 2036785-5

detail.hit.zdb_id: 1432-1

detail.hit.zdb_id: 410466-3

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10

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Ubiquitin-Conjugating Enzyme UBE2Q2 Suppresses Cell Proliferation and Is Down-Regulated in Recurrent Head and Neck Cancer

Maeda, Hiroyuki ; Miyajima, Naoto ; Kano, Satoshi ; [et al.]

American Association for Cancer Research (AACR) ; 2009

In: Molecular Cancer Research Vol. 7, No. 9 ( 2009-09-01), p. 1553-1562

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In: Molecular Cancer Research, American Association for Cancer Research (AACR), Vol. 7, No. 9 ( 2009-09-01), p. 1553-1562

Abstract: The ubiquitin-proteasome system has a crucial role in maintaining and regulating cellular homeostasis including carcinogenesis. UBE2Q2, also designated Ubci, is one of the ubiquitin-conjugating enzymes (E2), and it has been reported that mRNA of UBE2Q2 is highly expressed in human head and neck squamous cell carcinoma, particularly hypopharyngeal carcinoma. However, the involvement of UBE2Q2 in carcinogenesis has not been fully elucidated. Most cases of head and neck carcinoma are treated with cis-diamminedichloroplatinum (II; CDDP) or docetaxel, which are the most effective chemotherapeutic agents against squamous cell carcinomas. Nevertheless, some head and neck cancers develop resistance to these drugs, although the causes and mechanisms remain unknown. In this study, we found high expression levels of UBE2Q2 in human head and neck carcinoma cell lines and cancer tissues by using an anti-UBE2Q2 antibody at the protein level. We also found that the expression level of UBE2Q2 is decreased in cell lines and cancer tissues that have resistance to CDDP or docetaxel and in cancer tissues treated with CDDP or docetaxel. Furthermore, we found that overexpression of UBE2Q2 affects cell proliferation and anchorage-independent cell growth. These findings suggest that UBE2Q2 is a novel oncosuppressor that inhibits tumor growth and is related to the resistance to anticarcinoma agents and that UBE2Q2 likely functions as a novel diagnostic tool and a potentially therapeutic target for head and neck squamous cell carcinoma. (Mol Cancer Res 2009;7(9):1553–62)

Type of Medium: Online Resource

ISSN: 1541-7786 , 1557-3125

URL: Article

DOI: 10.1158/1541-7786.MCR-08-0543

Language: English

Publisher: American Association for Cancer Research (AACR)

Publication Date: 2009

detail.hit.zdb_id: 2097884-4

SSG: 12

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Kooperativer Bibliotheksverbund

Berlin Brandenburg