In:
The Journal of Clinical Pharmacology, Wiley, Vol. 22, No. 2-3 ( 1982-02-03), p. 97-101
Abstract:
Abstract: The effects of the antidiuretic agent chlorpropamide and the diuretic agent tolazamide on solute‐free water clearance ( C H 2 O) were compared in noninsulin‐dependent diabetic patients undergoing water diuresis. Hyperglycmia (fasting serum glucose above 200 mg/dl) obscured the effects of these two sulfonylureas on C H 2 O. Thiazide or ethacrynic acid enhancement of chlorpropamide antidiuresis was also blunted by hyperglycemia and attendant osmotic diuresis. Thus, the low incidence of symptomatic hyponatremia during chlorpropamide treatment of diabetic patients may be explained by persistent hyperglycemia in such patients.
Type of Medium:
Online Resource
ISSN:
0091-2700
,
1552-4604
DOI:
10.1002/jcph.1982.22.issue-2-3
DOI:
10.1002/j.1552-4604.1982.tb02655.x
Language:
English
Publisher:
Wiley
Publication Date:
1982
detail.hit.zdb_id:
2010253-7
SSG:
15,3
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