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  • 1
    Online Resource
    Online Resource
    Associations between liver function and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in non‐demented adults: The CABLE study
    Wiley ; 2024
    In:  Journal of Neurochemistry Vol. 168, No. 1 ( 2024-01), p. 39-51
    Details
    In: Journal of Neurochemistry, Wiley, Vol. 168, No. 1 ( 2024-01), p. 39-51
    Abstract: Liver function has been suggested as a possible factor in the progression of Alzheimer's disease (AD) development. However, the association between liver function and cerebrospinal fluid (CSF) levels of AD biomarkers remains unclear. In this study, we analyzed the data from 1687 adults without dementia from the Chinese Alzheimer's Biomarker and LifestylE study to investigate differences in liver function between pathological and clinical AD groups, as defined by the 2018 National Institute on Aging‐Alzheimer's Association Research Framework. We also examined the linear relationship between liver function, CSF AD biomarkers, and cognition using linear regression models. Furthermore, mediation analyses were applied to explore the potential mediation effects of AD pathological biomarkers on cognition. Our findings indicated that, with AD pathological and clinical progression, the concentrations of total protein (TP), globulin (GLO), and aspartate aminotransferase/alanine transaminase (ALT) increased, while albumin/globulin (A/G), adenosine deaminase, alpha‐L‐fucosidase, albumin, prealbumin, ALT, and glutamate dehydrogenase (GLDH) concentrations decreased. Furthermore, we also identified significant relationships between TP ( β = −0.115, p FDR 〈 0.001), GLO ( β = −0.184, p FDR 〈 0.001), and A/G ( β = 0.182, p FDR 〈 0.001) and CSF β‐amyloid 1–42 (Aβ 1–42 ) (and its related CSF AD biomarkers). Moreover, after 10 000 bootstrapped iterations, we identified a potential mechanism by which TP and GLDH may affect cognition by mediating CSF AD biomarkers, with mediation effect sizes ranging from 3.91% to 16.44%. Overall, our results suggested that abnormal liver function might be involved in the clinical and pathological progression of AD. Amyloid and tau pathologies also might partially mediate the relationship between liver function and cognition. Future research is needed to fully understand the underlying mechanisms and causality to develop an approach to AD prevention and treatment approach.
    Type of Medium: Online Resource
    ISSN: 0022-3042 , 1471-4159
    URL: Issue
    URL: Article
    DOI: 10.1111/jnc.v168.1
    DOI: 10.1111/jnc.16025
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2020528-4
    SSG: 12
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  • 2
    Online Resource
    Online Resource
    Application of the Amyloid/Tau/Neurodegeneration Framework in Cognitively Intact Adults: The CABLE Study
    Wiley ; 2022
    In:  Annals of Neurology Vol. 92, No. 3 ( 2022-09), p. 439-450
    Details
    In: Annals of Neurology, Wiley, Vol. 92, No. 3 ( 2022-09), p. 439-450
    Abstract: The amyloid/tau/neurodegeneration (AT[N]) framework has conceptualized the Alzheimer's disease (AD) continuum as a continuum of disease with evidence of amyloid‐related pathologies independent of clinical manifestation. Based on this framework, it is necessary to reveal the distribution and risk factors of AD continuum in the cognitively intact population among different cohorts and races, including the northern Chinese Han population. Methods This study classified cognitively intact Chinese Alzheimer's Biomarker and LifestylE (CABLE) participants through the AT(N) scheme. Gaussian mixture models were used to identify the cutoff values of cerebrospinal fluid biomarkers, which distinguished AD continuum ( A + T−N−, A + T + N−, A + T−N + and A + T + N +) from 1,005 participants (mean age 61 years; 40% female). Multivariable logistic regressions and Cochran–Armitage trend tests were used to test neuropsychological performance and risk factors for AD continuum. Results Approximately one‐third of individuals (33.7%) belonged to the AD continuum. Four potential modifiable risk factors, including hypertension, thyroid diseases, social isolation, and minimal depression symptoms, were identified for the AD continuum (OR ranging 1.68–6.90). A trend toward higher prevalence of the AD continuum was associated with a larger number of risk factors ( p for trend 〈 0.0001). The risk of AD continuum increased by approximately twofold for each additional modifiable risk factor (OR 1.9, 95% CI 1.65–2.24, p   〈  0.0001). Interpretation This study revealed the distribution and potential risk factors of the AD continuum in a cognitively intact Han population in northern China, which filled the gap in the area about the performance of the AT(N) framework in the Asian population. ANN NEUROL 2022;92:439–450
    Type of Medium: Online Resource
    ISSN: 0364-5134 , 1531-8249
    URL: Issue
    URL: Article
    DOI: 10.1002/ana.v92.3
    DOI: 10.1002/ana.26439
    Language: English
    Publisher: Wiley
    Publication Date: 2022
    detail.hit.zdb_id: 2037912-2
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  • 3
    Online Resource
    Online Resource
    Time spent in outdoor light is associated with the risk of dementia: a prospective cohort study of 362094 participants
    Springer Science and Business Media LLC ; 2022
    In:  BMC Medicine Vol. 20, No. 1 ( 2022-12)
    Details
    In: BMC Medicine, Springer Science and Business Media LLC, Vol. 20, No. 1 ( 2022-12)
    Abstract: Data on the association between free-living daytime sunlight exposure and incident dementia are scarce. The objective is to evaluate whether the time spent in outdoor light is related to the dementia risk and to investigate whether the optimal duration varies with clinical parameters. Methods Data were from a prospective cohort of 362,094 UK Biobank participants. A questionnaire survey was conducted to investigate how many hours the participants spent outdoors on typical summer and winter days. A restricted cubic spline (RCS) was performed to explore the potential nonlinear relationship between sunlight exposure and the risk of dementia. We used multivariate Cox proportional hazard regression models to estimate the hazard ratios (HRs) for the associations between sunlight exposure and dementia outcomes, with the change points as a reference. Results After a median follow-up of 9.0 years, 4149 (1.15%) individuals were diagnosed with dementia. RCS showed a J-shaped relationship between time spent in outdoor light and the dementia risk, with the lowest risk at three change points (1.5 h/day on average, 2 h/day in summer, and 1 h/day in winter). Cox hazard regression models showed a marked increase in risk at low exposure (HR=1.287, 95%CI 1.094–1.515) but a relatively slow increase at higher exposure (HR=1.070, 95%CI 1.031–1.10). Results are more pronounced among participants over 60 years old, females, and those with exactly 7 h of sleep every night. Conclusions Sunlight exposure had a J-shaped association with dementia risk. Giving detailed guidance on sunlight exposure can effectively prevent dementia.
    Type of Medium: Online Resource
    ISSN: 1741-7015
    URL: Article
    DOI: 10.1186/s12916-022-02331-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2022
    detail.hit.zdb_id: 2131669-7
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  • 4
    Online Resource
    Online Resource
    Data_Sheet_2.pdf
    Frontiers Media SA ; 2022
    In:  Frontiers in Aging Neuroscience Vol. 14 ( 2022-12-16)
    Details
    In: Frontiers in Aging Neuroscience, Frontiers Media SA, Vol. 14 ( 2022-12-16)
    Abstract: Neurofilament light chain protein (NfL) in cerebrospinal fluid (CSF) reflects the severity of neurodegeneration, with its altered concentrations discovered in Parkinson’s disease (PD) and Parkinson’s disease dementia (PD-D). Objective To determine whether CSF NfL, a promising biomarker of neuronal/axonal damage, can be used to monitor cognitive progression in de novo Parkinson’s disease and predict future cognitive decline. Methods A total of 259 people were recruited in this study, including 85 healthy controls (HC) and 174 neonatal PD patients from the Parkinson’s Progression Markers Initiative (PPMI). Multiple linear regression and linear mixed effects models were used to examine the associations of baseline/longitudinal CSF NfL with cognitive decline and other CSF biomarkers. Kaplan–Meier analysis and log-rank test were used to compare the cumulative probability risk of cognition progression during the follow-up. Multivariate cox regression was used to detect cognitive progression in de novo PD. Results We found PD patients with mild cognitive impairment (PD-MCI) was higher than with normal cognition (PD-NC) in terms of CSF NfL baseline levels ( p  = 0.003) and longitudinal increase rate ( p  = 0.034). Both baseline CSF NfL and its rate of change predicted measurable cognitive decline in de novo PD (MoCA, β  = −0.010, p  = 0.011; β  = −0.0002, p   & lt; 0.001, respectively). The predictive effects in de novo PD patients aged & gt;65, male, ill-educated ( & lt;13 years) and without carrying Apolipoprotein E ε4 ( APOE ε4 ) seemed to be more obvious and reflected in more domains investigated. We also observed that CSF NfL levels predicted progression in de novo PD patients with different cognitive diagnosis and amyloid status. After an average follow-up of 6.66 ± 2.54 years, higher concentration above the median of baseline CSF NfL was associated with a future high risk of PD with dementia (adjusted HR 2.82, 95% CI: 1.11–7.20, p  = 0.030). Conclusion Our results indicated that CSF NfL is a promising prognostic predictor of PD, and its concentration and dynamics can monitor the severity and progression of cognitive decline in de novo PD patients.
    Type of Medium: Online Resource
    ISSN: 1663-4365
    URL: Article
    URL: Article
    URL: Article
    DOI: 10.3389/fnagi.2022.1061096
    DOI: 10.3389/fnagi.2022.1061096.s001
    DOI: 10.3389/fnagi.2022.1061096.s002
    Language: Unknown
    Publisher: Frontiers Media SA
    Publication Date: 2022
    detail.hit.zdb_id: 2558898-9
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  • 5
    Online Resource
    Online Resource
    Social Networks and Cerebrospinal Fluid Biomarkers of Alzheimer’s Disease Pathology in Cognitively Intact Older Adults: The CABLE Study
    IOS Press ; 2021
    In:  Journal of Alzheimer's Disease Vol. 81, No. 1 ( 2021-05-04), p. 263-272
    Details
    In: Journal of Alzheimer's Disease, IOS Press, Vol. 81, No. 1 ( 2021-05-04), p. 263-272
    Abstract: Background: Although social networks are deemed as moderators of incident Alzheimer’s disease (AD), few data are available on the mechanism relevant to AD pathology. Objective: We aimed to investigate whether social networks affect metabolism of cerebrospinal fluid (CSF) AD biomarkers during early stage and identify modification effects of genetic factor and subjective cognitive decline (SCD). Methods: We studied participants from the Chinese Alzheimer’s disease Biomarker and Lifestyle (CABLE) database who received cognition assessments and CSF amyloid-β (Aβ1–42 and Aβ1–40) and tau proteins (total-tau [T-tau] and phosphorylated-tau [P-tau] ) measurements. The social networks were measured using self-reported questionnaires about social ties. Linear regression models were used. Results: Data were analyzed from 886 cognitively intact individuals aged 61.91 years (SD = 10.51), including 295 preclinical AD participants and 591 healthy controls. Social networks were mostly associated with CSF indicators of AD multi-pathologies (low P-tau/Aβ1–42 and T-tau/Aβ1–42 and high Aβ1–42/Aβ1–40). Significant differences of genetic and cognitive status were observed for CSF indicators, in which associations of social network scores with CSF P-tau and indicators of multi-pathologies appeared stronger in APOE 4 carriers (versus non-carriers) and participants with SCD (versus controls), respectively. Alternatively, more pronounced associations for CSF T-tau (β= –0.005, p  〈  0.001), Aβ1–42/Aβ1–40 (β= 0.481, p = 0.001), and T-tau/Aβ1–42 (β= –0.047, p  〈  0.001) were noted in preclinical AD stage than controls. Conclusion: These findings consolidated strong links between social networks and AD risks. Social networks as a modifiable lifestyle probably affected metabolisms of multiple AD pathologies, especially among at-risk populations.
    Type of Medium: Online Resource
    ISSN: 1387-2877 , 1875-8908
    URL: Article
    DOI: 10.3233/JAD-201426
    Language: Unknown
    Publisher: IOS Press
    Publication Date: 2021
    detail.hit.zdb_id: 2070772-1
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  • 6
    Online Resource
    Online Resource
    Associations of Physical Activity with Alzheimer’s Disease Pathologies and Cognition: The CABLE Study
    IOS Press ; 2022
    In:  Journal of Alzheimer's Disease Vol. 89, No. 2 ( 2022-09-13), p. 483-492
    Details
    In: Journal of Alzheimer's Disease, IOS Press, Vol. 89, No. 2 ( 2022-09-13), p. 483-492
    Abstract: Background: The associations of physical activity with Alzheimer’s disease (AD) pathologies remain controversial. Objective: To quantitatively assess the association between the frequency of physical activity with cerebrospinal fluid (CSF) biomarkers in AD and further explore the mechanism by which AD pathologies regulate the correlation between physical activity and cognition. Methods: A total of 918 participants without dementia from Chinese Alzheimer’s Biomarker and Lifestyle (CABLE) were examined in this population-based cross-sectional study. Multiple linear models were used to evaluate the associations of physical activity with CSF biomarkers and cognition. Moreover, mediation analyses were conducted to investigate the potential relationships between physical activity, AD pathologies, and cognitive function. Results: Regular physical activity was positively associated with CSF Aβ42 (p  〈  0.001) and Aβ42/40 (p  〈  0.001), while it was negatively associated with p-tau/Aβ42 (p  〈  0.001) and t-tau/Aβ42 (p  〈  0.001). Of all participants, regular physical activity was associated with increased cognitive function (p  〈  0.001). The interaction effect indicated that age moderated the association between physical activity frequency and CSF Aβ42 (p = 0.014) and p-tau/Aβ42 (p = 0.041). The impact of physical activity on cognition was mediated in part by amyloid pathologies, accounting for 4.87% to 21.56% of the total effect (p  〈  0.05). Conclusion: This study showed the beneficial impact of physical activity on AD pathologies and cognition in participants without dementia.
    Type of Medium: Online Resource
    ISSN: 1387-2877 , 1875-8908
    URL: Article
    DOI: 10.3233/JAD-220389
    Language: Unknown
    Publisher: IOS Press
    Publication Date: 2022
    detail.hit.zdb_id: 2070772-1
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  • 7
    Online Resource
    Online Resource
    Associations of liver dysfunction with incident dementia, cognition, and brain structure: A prospective cohort study of 431 699 adults
    Wiley ; 2024
    In:  Journal of Neurochemistry Vol. 168, No. 1 ( 2024-01), p. 26-38
    Details
    In: Journal of Neurochemistry, Wiley, Vol. 168, No. 1 ( 2024-01), p. 26-38
    Abstract: The relationship between liver dysfunction and dementia has been researched extensively but remains poorly understood. In this study, we investigate the longitudinal and cross‐sectional associations between liver function and liver diseases and risk of incident dementia, impaired cognition, and brain structure abnormalities using Cox proportion hazard model and linear regression model. 431 699 participants with a mean of 8.65 (standard deviation [SD] 2.61) years of follow‐up were included from the UK Biobank; 5542 all‐cause dementia (ACD), 2427 Alzheimer's disease (AD), and 1282 vascular dementia (VaD) cases were documented. We observed that per SD decreases in alanine transaminase (ALT; hazard ratio [HR], 0.917; P FDR 〈 0.001) and per SD increases in aspartate aminotransferase (AST; HR, 1.048; P FDR = 0.010), AST to ALT ratio (HR, 1.195; P FDR 〈 0.001), gamma‐glutamyl transpeptidase (GGT; HR, 1.066; P FDR 〈 0.001), alcoholic liver disease (ALD; HR, 2.872; P FDR 〈 0.001), and fibrosis and cirrhosis of liver (HR, 2.285; P FDR = 0.002), being significantly associated with a higher risk of incident ACD. Restricted cubic spline models identified a strong U‐shaped association between Alb and AST and incident ACD ( P nonlinear 〈 0.05). Worse cognition was positively correlated with AST, AST to ALT ratio, direct bilirubin (DBil), and GGT; negatively correlated with ALT, Alb, and total bilirubin (TBil); and ALD and fibrosis and cirrhosis of liver ( P FDR 〈 0.05). Moreover, changes in ALT, GGT, AST to ALT ratio, and ALD were significantly associated with altered cortical and subcortical regions, including hippocampus, amygdala, thalamus, pallidum, and fusiform ( P FDR 〈 0.05). In sensitivity analysis, metabolic dysfunction‐associated steatotic liver disease (MASLD) was associated with the risk of ACD and brain subcortical changes. Our findings provide substantial evidence that liver dysfunction may be an important factor for incident dementia. Early intervention in the unhealthy liver may help prevent cognitive impairment and dementia incidence.
    Type of Medium: Online Resource
    ISSN: 0022-3042 , 1471-4159
    URL: Issue
    URL: Article
    DOI: 10.1111/jnc.v168.1
    DOI: 10.1111/jnc.15988
    Language: English
    Publisher: Wiley
    Publication Date: 2024
    detail.hit.zdb_id: 2020528-4
    SSG: 12
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  • 8
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    Online Resource
    Associations of Sleep Characteristics with Cerebrospinal Fluid sTREM2 in Cognitively Normal Older Adults: the CABLE Study
    Springer Science and Business Media LLC ; 2021
    In:  Neurotoxicity Research Vol. 39, No. 4 ( 2021-08), p. 1372-1380
    Details
    In: Neurotoxicity Research, Springer Science and Business Media LLC, Vol. 39, No. 4 ( 2021-08), p. 1372-1380
    Type of Medium: Online Resource
    ISSN: 1029-8428 , 1476-3524
    URL: Article
    DOI: 10.1007/s12640-021-00383-5
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2074876-0
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  • 9
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    Online Resource
    Transverse momentum spectra of J/ψ produced in collisions over an energy range from 17.4 GeV to 13 TeV
    IOP Publishing ; 2020
    In:  Journal of Physics G: Nuclear and Particle Physics Vol. 47, No. 4 ( 2020-04-01), p. 045111-
    Details
    In: Journal of Physics G: Nuclear and Particle Physics, IOP Publishing, Vol. 47, No. 4 ( 2020-04-01), p. 045111-
    Abstract: Transverse momentum spectra of inclusive J / ψ mesons produced in particle–particle, particle–nucleus and nucleus–nucleus collisions over a center-of-mass energy range from 17.4 GeV to 13 TeV are analyzed by a multi-component Schwinger mechanism. The model results are found to fit the experimental data measured by the ALICE, CDF, D0, HERA-B, E789, NA50, E705, LHCb and PHENIX Collaborations. We extract the distribution of minimum distance between the partons which form the charmonium c c ¯ . Moreover, the energy and rapidity dependent free parameters in Schwinger mechanism are obtained. The parameter related to string tension is found to increase with the increase of energy and to decrease with the increase of rapidity and centrality.
    Type of Medium: Online Resource
    ISSN: 0954-3899 , 1361-6471
    URL: Article
    DOI: 10.1088/1361-6471/ab67e6
    RVK:
    UA 4720.G
    Language: Unknown
    Publisher: IOP Publishing
    Publication Date: 2020
    detail.hit.zdb_id: 1472964-7
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  • 10
    Online Resource
    Online Resource
    Associations between multimorbidity burden and Alzheimer’s pathology in older adults without dementia: the CABLE study
    Elsevier BV ; 2024
    In:  Neurobiology of Aging Vol. 134 ( 2024-02), p. 1-8
    Details
    In: Neurobiology of Aging, Elsevier BV, Vol. 134 ( 2024-02), p. 1-8
    Type of Medium: Online Resource
    ISSN: 0197-4580
    URL: Article
    DOI: 10.1016/j.neurobiolaging.2023.09.014
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2024
    detail.hit.zdb_id: 1498414-3
    SSG: 12
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