In:
Immunology, Wiley, Vol. 154, No. 2 ( 2018-06), p. 261-273
Abstract:
Deep characterization of the frequencies, phenotypes and functionalities of liver and peripheral blood natural killer ( NK ), natural killer T ( NKT ) and T cells from healthy individuals is an essential step to further interpret changes in liver diseases. These data indicate that CCR 7, a chemokine essential for cell migration through lymphoid organs, is almost absent in liver NK and T cells. CD 56 bright NK cells, which represent half of liver NK cells, showed lower expression of the inhibitory molecule NKG 2A and an increased frequency of the activation marker NK p44. By contrast, a decrease of CD 16 expression with a potential decreased capacity to perform antibody‐dependent cellular cytotoxicity was the main difference between liver and peripheral blood CD 56 dim NK cells. Liver T cells with an effector memory or terminally differentiated phenotype showed an increased frequency of MAIT cells,T‐cell receptor‐ γδ ( TCR ‐ γδ ) T cells and TCR ‐ αβ CD 8 + cells, with few naive T cells. Most liver NK and T cells expressed the homing markers CD 161 and CD 244. Liver T cells revealed a unique expression pattern of killer cell immunoglobulin‐like receptors ( KIR ) receptors, with increased degranulation ability and higher secretion of interferon‐ γ . Hence, the liver possesses a large amount of memory and terminally differentiated CD 8 + cells with a unique expression pattern of KIR activating receptors that have a potent functional capacity as well as a reduced amount of CCR 7, which are unable to migrate to regional lymph nodes. These results are consistent with previous studies showing that liver T (and also NK ) cells likely remain and die in the liver.
Type of Medium:
Online Resource
ISSN:
0019-2805
,
1365-2567
DOI:
10.1111/imm.2018.154.issue-2
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2006481-0
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