In:
Critical Care Research and Practice, Hindawi Limited, Vol. 2014 ( 2014), p. 1-8
Abstract:
Background . The aim of this study was to investigate whether different haemofilter surface areas affect clotting and platelet consumption in critically ill patients undergoing continuous venovenous haemodiafiltration (CVVHDF). Methods . CVVHDF was performed in postdilution technique using a capillary haemofilter with two different membrane sizes, Ultraflux AV 1000S ( n = 17 , surface 1.8 m 2 , volume 130 mL), and the smaller AV 600S ( n = 16 , surface 1.4 m 2 , volume 100 mL), respectively. Anticoagulation was performed with heparin. Results . No significant differences were found when the two filters were compared. CVVHDF was performed for 33 (7–128) hours with the filter AV 1000S and 39 (7–97) hours with AV 600S ( P = 0.68 ). Two (1–4) filters were utilised in both groups over this observation period ( P = 0.94 ). Platelets dropped by 52,000 (0–212,000) in AV 1000S group and by 89,500 (0–258,000) in AV 600S group ( P = 0.64 ). Haemoglobin decreased by 1.2 (0–2.8) g/dL in AV 1000S group and by 1.65 (0–3.9) g/dL in AV 600S group ( P = 0.51 ), leading to the transfusion of 1 (0–4) unit of blood in 19 patients (10 patients with AV 1000S and 9 with AV 600S). Filter observation was abandoned due to death (12.1%), need for systemic anticoagulation (12.1%), repeated clotting (36.4%), and recovery of renal function (39.4%). Conclusion . Our study showed that a larger filter surface area did neither reduce the severity of thrombocytopenia and anaemia, nor decrease the frequency of clotting events.
Type of Medium:
Online Resource
ISSN:
2090-1305
,
2090-1313
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2014
detail.hit.zdb_id:
2573849-5
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