In:
Asian Journal of Pharmaceutical and Clinical Research, Innovare Academic Sciences Pvt Ltd, Vol. 11, No. 12 ( 2018-12-07), p. 143-
Abstract:
Objective: Antimicrobial resistance is a growing problem in Helicobacter pylori eradication which is a microaerophilic bacterium causing various gastroduodenal diseases. The present study has been designed to test the efficacy of Morinda coreia against the metronidazole clarithromycin and levofloxacin-resistant H. pylori strains isolated from the biopsy taken from the patient suffering from gastric erosion in Guwahati, Assam.Method: The antimicrobial activity of n-hexane and chloroform extract of M. coreia was tested against multidrug-resistant H. pylori isolate of Guwahati, Assam, by agar well method and microdilution method.Result: In the present study, the H. pylori strain resistant for metronidazole (minimal inhibitory concentration [MIC] 〉 64 μg/mL), clarithromycin at (MIC 〉 0.5 μg/mL), and levofloxacin at (MIC 〉 1 μg/mL) was tested against the n-hexane and chloroform extract of M. coreia. Both the extracts of M. coreia showed good efficacy against the multidrug-resistant strain of H. pylori shown inhibition at 1.2 μg/mL with n-hexane extract and 2 μg/mL with chloroform extract of M. coreia. Conclusion: The prevalence of metronidazole-resistant ranges between 50% and 90% in the developing countries, including India, clarithromycin ranges from 0% to 15% in India, and levofloxacin ranges between 50% and 70% in India, so there is a need of alternative therapy for the eradication of this bacterium from the stomach. Hence, this study suggests that M. coreia, which has been used traditionally as a folk medicine for the treatment of many gastric diseases, has also shown good efficacy against the multidrug-resistant H. pylori strain of North-east India.
Type of Medium:
Online Resource
ISSN:
2455-3891
,
0974-2441
DOI:
10.22159/ajpcr.2018.v11i12.28064
Language:
Unknown
Publisher:
Innovare Academic Sciences Pvt Ltd
Publication Date:
2018
detail.hit.zdb_id:
2500247-8
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