In:
Genes & Development, Cold Spring Harbor Laboratory, Vol. 23, No. 15 ( 2009-08-01), p. 1737-1742
Abstract:
Epithelial-to-mesenchymal transition (EMT) plays an important role during normal embryogenesis, and it has been implicated in cancer invasion and metastasis. Here, we report that Ladybird homeobox 1 ( LBX1 ), a developmentally regulated homeobox gene, directs expression of the known EMT inducers ZEB1 , ZEB2 , Snail1 , and transforming growth factor β2 ( TGFB2 ). In mammary epithelial cells, overexpression of LBX1 leads to morphological transformation, expression of mesenchymal markers, enhanced cell migration, increased CD44 high /CD24 low progenitor cell population, and tumorigenic cooperation with known oncogenes. In human breast cancer, LBX1 is up-regulated in the unfavorable estrogen receptor (ER)/progesterone (PR)/HER2 triple-negative basal-like subtype. Thus, aberrant expression of LBX1 may lead to the activation of a developmentally regulated EMT pathway in human breast cancer.
Type of Medium:
Online Resource
ISSN:
0890-9369
,
1549-5477
Language:
English
Publisher:
Cold Spring Harbor Laboratory
Publication Date:
2009
detail.hit.zdb_id:
1467414-2
SSG:
12
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