In:
Cardiovascular Therapy and Prevention, Silicea - Poligraf, LLC, Vol. 22, No. 5 ( 2023-06-08), p. 3548-
Abstract:
Aim . To assess the significance of troponin I (hs-cTnI) for cardiovascular risk stratification in a population of Russian working-age men and women of. Material and methods . The data of 13976 men and women aged 25-64 from the ESSE-RF1 and ESSE-RF2 multicenter studies were analyzed. The examination included following points: standard questionnaire, measurements of height, weight, waist circumference, body mass index, blood pressure, pulse rate, biochemical tests. The level of hs-cTnI in blood serum samples stored at -70 о C in the Biobank of the National Medical Research Center for Therapy and Preventive Medicine was determined by chemiluminescent immunoassay analysis. Individual cardiovascular risk was calculated using the SCORE scale: values 〈 1% — low risk; 1-4% — moderate, 5-9% — high and ≥10% very high. Similar to the BiomarCaRE study, participants were divided into 3 sex-adjusted cTnI levels: men 〈 6, 6 to 12, and 〉 12 pg/ml; women 〈 4, 4 to 10, and 〉 10 pg/ml. We analyzed following hard endpoints: cardiovascular death or non-fatal myocardial infarction, and composite endpoint: the same and stroke. Results . The prospective analysis of the relationship between troponin levels and endpoints and composite endpoints showed that in participants without prior CVD, hs-cTnI levels 〉 12 pg/ml in men and 〉 10 pg/ml in women are associated with an increased risk of endpoints and composite endpoints by 3,39 (1,91-6,03) and 2,69 (1,6-4,52) times (p 〈 0,001), respectively. Similarly to BiomarCaRE, the SCORE-calculated risk reclassification was validated by adding the hs-cTnI value. The net reclassification improvement index (NRI) for endpoints and composite endpoints was 13% and 11% (p 〈 0,001), respectively. Among men, the reclassification for NRI composite endpoints was more accurate than among women: 19% and 11%, respectively. Conclusion . The hs-cTnI level is an independent predictor of myocardial infarction, stroke, and death from CVD in people aged 35-64 years without prior CVD. Adding the hs-cTnI level to the SCORE model makes the risk prediction more accurate.
Type of Medium:
Online Resource
ISSN:
2619-0125
,
1728-8800
DOI:
10.15829/1728-8800-2023-5
DOI:
10.15829/1728-8800-2023-3548
Language:
Unknown
Publisher:
Silicea - Poligraf, LLC
Publication Date:
2023
detail.hit.zdb_id:
3032202-9
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