In:
CNS & Neurological Disorders - Drug Targets, Bentham Science Publishers Ltd., Vol. 20, No. 5 ( 2021-11-08), p. 473-477
Abstract:
Catatonia is a psychomotor syndrome that presents with severe symptoms
which can lead to dangerous and lethal conditions if not diagnosed and treated properly. SARS-- CoV-2 is a positive-sense single-stranded RNA virus that can occur in severe cases with acute
pneumonia, ARDS, sepsis and septic shock. In these cases, ICU admission is necessary. Case Summary: A 59-year-old Caucasian man with septic shock and bilateral interstitial pneumonia
from SARS-CoV-2 and schizotypal personality disorder presented with catatonic behaviour manifested by soporous state, response to intense painful stimuli with the opening of the eyes, execution
of simple verbal commands, maintenance of the same position, catalepsy, immobility, rigidity and mutism. At the same time, there were symptoms of septic shock and catatonic symptoms,
causing greater difficulty in the correct formulation of the diagnosis. During the course of his hospitalization, he was treated with asenapine 20 mg/day. The catatonia responded rapidly and significantly
to the asenapine. Discussion: To date, the pathophysiology of catatonia is unclear, and few guidelines are available
for the treatment of catatonia. In the literature, studies have reported the efficacy of benzodiazepines such as lorazepam and diazepam, GABAA agonists such as zolpidem, NMDA receptor antagonists
such as memantine, antidepressant SSRIs such as fluoxetine and paroxetine, and antipsychotics such as olanzapine, clozapine and aripiprazole. We demonstrate that the antipsychotic asenapine
is also effective in treating catatonic symptoms in psychiatric disorders. Conclusion: Asenapine produced a rapid and significant reduction in catatonic symptoms in our patient
with schizotypal personality disorder.
Type of Medium:
Online Resource
ISSN:
1871-5273
DOI:
10.2174/1871527320666210226114238
Language:
English
Publisher:
Bentham Science Publishers Ltd.
Publication Date:
2021
SSG:
15,3
Bookmarklink