In:
Cardiology, S. Karger AG, Vol. 90, No. 1 ( 1998), p. 43-47
Abstract:
Lymphocytes can be activated to produce and release opioid peptides. We investigated the levels of immunoreactive β-endorphin in peripheral blood mononuclear cells from 11 patients with acute myocardial infarction. The concentrations of β-endorphin in mononuclear leukocytes of 30.2 ± 6.9 pg/10 〈 sup 〉 6 〈 /sup 〉 cells on admission were in the normal range of 20–40 pg/10 〈 sup 〉 6 〈 /sup 〉 cells and decreased significantly to 6.9 ± 1.9 pg/10 〈 sup 〉 6 〈 /sup 〉 cells after 48 h (p 〈 0.05). Decreased levels of mononuclear leukocyte-associated β-endorphin in acute myocardial infarction may be due to the release of endogenous opioid after stimulation by stress and acute-phase reactants and play a role in inflammation and pain.
Type of Medium:
Online Resource
ISSN:
0008-6312
,
1421-9751
Language:
English
Publisher:
S. Karger AG
Publication Date:
1998
detail.hit.zdb_id:
1482041-9
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