In:
Clinical Transplantation, Wiley, Vol. 26, No. 5 ( 2012-09), p. 755-763
Abstract:
Congenital heart diseases ( CHD s) have high infant mortality in their severe forms. When adulthood is reached, a heart transplant ( HT x) may be required. Spanish adult population transplanted for CHD was analyzed and compared with the most frequent causes of HT x and between different subgroups of CHD . Materials and Methods A total of 6048 patients ( HT x 1984–2009) were included. Pediatric transplants ( 〈 15 yr), combined transplants, re HT x, and HT x for heart diseases other than idiopathic dilated cardiomyopathy ( IDCM ) and ischemic heart disease ( IHD ) were excluded. Total patients included: 3166 ( IHD = 1888; IDCM = 1223; CHD = 55). Subgroups were studied as follows: (1) single ventricle with pulmonary stenosis (n = 18), (2) single ventricle with tricuspid atresia and G lenn/ F ontan surgery (n = 10), (3) congenitally corrected transposition of the great vessels ( TGV ) or with switch atrial surgery (n = 10), and (4) CHD with right ventricle overload (n = 17). Results Survival probability was different between groups (p = 0.0001). Post hoc analysis showed some differences between groups ( CHD vs. IHD , p = 0.05; CHD vs. IDCM , p = 0.5; IHD vs. IDCM , p = 0.0001). Early mortality was different between CHD subgroups (group 1 = 19%, group 2 = 40%, group 3 = 0%, group 4 = 29%; p 〈 0.001); however, overall mortality did not show differences between subgroups (p = 0.5). Conclusions The percentage of S panish adult HT x patients for CHD is low (1%). The survival curve is better than for other HT x causes ( IHD ). Nevertheless, early mortality was higher, particularly in some subgroups ( F ontan).
Type of Medium:
Online Resource
ISSN:
0902-0063
,
1399-0012
DOI:
10.1111/ctr.2012.26.issue-5
DOI:
10.1111/j.1399-0012.2012.01611.x
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2739458-X
detail.hit.zdb_id:
2004801-4
Bookmarklink