In:
FEBS Letters, Wiley, Vol. 198, No. 1 ( 1986-03-17), p. 164-168
Abstract:
Creutzfeldt‐Jakob disease is a slow, infectious, progressive neurological disorder which results in human dementia. Synaptic membranes from various brain regions of guinea pigs infected with Creutzfeldt‐Jakob disease show increased guanyl nucleotide‐ or 5‐hydroxytryptamine‐mediated activation of adenylate cyclase. This increased enzyme activity appears due, primarily, to facilitated ‘coupling’ between the GTP‐binding protein which stimulates adenylate cyclase (GN s ) and the catalytic moiety of that enzyme rather than increased sensitivity to 5‐hydroxytryptamine. It is possible that this phenomenon is due to direct effects of the Creutzfeldt‐Jakob infectious agent, or a pathological product resulting from that agent, upon synaptic membrane adenylate cyclase.
Type of Medium:
Online Resource
ISSN:
0014-5793
,
1873-3468
DOI:
10.1016/0014-5793(86)81205-4
Language:
English
Publisher:
Wiley
Publication Date:
1986
detail.hit.zdb_id:
1460391-3
SSG:
12
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