In:
The Journal of Clinical Hypertension, Wiley, Vol. 16, No. 9 ( 2014-09), p. 634-639
Abstract:
The aim of this study was to investigate the association of v itamin D receptor ( VDR ) gene polymorphism and hypertension in a C hinese H an population. The authors genotyped 3 tag SNP s (rs11574129, rs2228570, and rs739837) of the VDR gene using T aq M an assays in a case‐control study including 2409 patients with hypertension and 3063 controls. The results showed that rs2228570 presented statistical correlations with decreased risk of male hypertension after adjustment for confounding factors, odds ratios ( OR s) and 95% confidence intervals ( CIs ) of additive, dominant, and recessive models were 0.828 (0.74–0.927), 0.75 (0.631–0.89), and 0.816 (0.67–0.995), and P values were .001, .001, and .044, respectively. Significant associations were found in the smoking population and OR s (95% CIs ) of additive and dominant models were 0.81 (0.69–0.952) and 0.71 (0.552–0.913) ( P values .011 and .008), respectively, after adjustment for covariates. Quantitative trait analysis indicated that the untreated cases with TT genotype of rs2228570 showed higher systolic blood pressure compared with the TC / CC genotype ( P =.015). Our findings suggest that VDR genetic polymorphism rs2228570 is significantly associated with the decreased risk of hypertension in C hinese men and smokers.
Type of Medium:
Online Resource
ISSN:
1524-6175
,
1751-7176
DOI:
10.1111/jch.2014.16.issue-9
Language:
English
Publisher:
Wiley
Publication Date:
2014
detail.hit.zdb_id:
2058690-5
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