In:
French-Ukrainian Journal of Chemistry, Taras Shevchenko National University of Kyiv, Vol. 3, No. 1 ( 2015), p. 21-28
Abstract:
The chemistry of three prototypes of secondary alkynylcarbinols (ACs), recently highlighted as challenging targets in anti-tumoral medicinal chemistry, is further documented by results on n-alkyl, alkynyl and alkenyl representatives. The N-naphthyl carbamate of an n-butyl-AC is thus characterized by X-ray crystallography. A novel dialkynylcarbinol (DAC) with synthetic potential is described, namely the highly dissymmetrical triisopropylsilyl-protected version of diethynylmethanol. The latter is shown to act as a dipolarophile in a selective Huisgen reaction with benzyl azide under CuAAC click conditions, giving an alkenyl-AC, where the alkene unsaturation is embedded in a 1,4-disubstituted 1,2,3-triazole ring, as confirmed by X-ray crystallography.
Type of Medium:
Online Resource
ISSN:
2312-3222
DOI:
10.17721/fujcV3I1P21-28
Language:
English
Publisher:
Taras Shevchenko National University of Kyiv
Publication Date:
2015
detail.hit.zdb_id:
2921413-0
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