In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 7 ( 2022-7-21), p. e0270736-
Abstract:
Almost 200 million children worldwide are either undernourished or overweight. Only a few studies have addressed the effect of variation in nutritional status on vaccine response. We previously demonstrated an association between stunting and an increased post-vaccination 13-valent pneumococcal conjugate vaccine (PCV13) response. In this prospective study, we assessed to what extent metabolic hormones may be a modifier in the association between nutritional status and PCV13 response. Methods Venezuelan children aged 6 weeks to 59 months were vaccinated with a primary series of PCV13. Nutritional status and serum levels of leptin, adiponectin and ghrelin were measured upon vaccination and their combined effect on serum post-vaccination antibody concentrations was assessed by generalized estimating equations multivariable regression analysis. Results A total of 210 children were included, of whom 80 were stunted, 81 had a normal weight and 49 were overweight. Overweight children had lower post-vaccination antibody concentrations than normal weight children (regression coefficient -1.15, 95% CI -2.22 –-0.072). Additionally, there was a significant adiponectin-nutritional status interaction. In stunted children, higher adiponectin serum concentrations were associated with lower post-PCV13 antibody concentrations (regression coefficient -0.19, 95% CI -0.24 –-0.14) while the opposite was seen in overweight children (regression coefficient 0.14, 95% CI 0.049–0.22). Conclusion Metabolic hormones, in particular adiponectin, may modify the effect of nutritional status on pneumococcal vaccine response. These findings emphasize the importance of further research to better understand the immunometabolic pathways underlying vaccine response and enable a future of optimal personalized vaccination schedules.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0270736
DOI:
10.1371/journal.pone.0270736.g001
DOI:
10.1371/journal.pone.0270736.g002
DOI:
10.1371/journal.pone.0270736.t001
DOI:
10.1371/journal.pone.0270736.t002
DOI:
10.1371/journal.pone.0270736.t003
DOI:
10.1371/journal.pone.0270736.s001
DOI:
10.1371/journal.pone.0270736.s002
DOI:
10.1371/journal.pone.0270736.s003
DOI:
10.1371/journal.pone.0270736.r001
DOI:
10.1371/journal.pone.0270736.r002
DOI:
10.1371/journal.pone.0270736.r003
DOI:
10.1371/journal.pone.0270736.r004
DOI:
10.1371/journal.pone.0270736.r005
DOI:
10.1371/journal.pone.0270736.r006
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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