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Supplementary material 6 from: Benítez-Benítez C, Jiménez-Mejías P, Luceño M, Martín-Bravo S (2023) Carex quixotiana (Cyperaceae), a new Iberian endemic from Don Quixote’s land (La Mancha, S Spain). PhytoKeys 221: 161-186. https://doi.org/10.3897/phytokeys.221.99234

Benítez-Benítez, Carmen ; Jiménez-Mejías, Pedro ; Luceño, Modesto ; [et al.]

Pensoft Publishers ; 2023

In: PhytoKeys Vol. 221 ( 2023-03-14), p. 161-186

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In: PhytoKeys, Pensoft Publishers, Vol. 221 ( 2023-03-14), p. 161-186

Abstract: Despite centuries of work, the basic taxonomic knowledge of the flora of the Iberian Peninsula is still incomplete, especially for highly diverse and/or difficult genera such as Carex . In this study, we conducted an integrative systematic study based on molecular, morphological and cytogenetic data to elucidate the taxonomic status of several problematic Carex populations from La Mancha region (S Spain) belonging to Carex sect. Phacocystis. These populations have been traditionally considered of uncertain taxonomic adscription, but close to C. reuteriana due to their morphological appearance and ecological preferences. A detailed morphological and cytogenetic study was performed on 16 La Mancha’s problematic populations (Sierra Madrona and Montes de Toledo) to compare them with the other Iberian sect. Phacocystis species. In addition, a phylogenetic analysis was conducted using two nuclear (ITS, ETS) and two plastid ( rpl 32‐ trn L UAG , ycf 6‐ psb M) DNA regions, including representatives from all species of sect. Phacocystis. We found a significant degree of molecular and morphological differentiation that supports the recognition of La Mancha’s problematic populations as a new Iberian endemic species, described here as Carex quixotiana Ben.Benítez, Martín-Bravo, Luceño & Jim.Mejías. Our results reveal that C. quixotiana , unexpectedly, is more closely related to C. nigra than to C. reuteriana on the basis of phylogenetic relationships and chromosome number. These contrasting patterns reflect the taxonomic complexity in sect. Phacocystis and highlight the need for integrative systematic approaches to disentangle such complicated evolutionary scenarios.

Type of Medium: Online Resource

ISSN: 1314-2003 , 1314-2011

URL: Article

DOI: 10.3897/phytokeys.221.99234

DOI: 10.3897/phytokeys.221.99234.figure1

DOI: 10.3897/phytokeys.221.99234.figure2

DOI: 10.3897/phytokeys.221.99234.figure3

DOI: 10.3897/phytokeys.221.99234.figure4

DOI: 10.3897/phytokeys.221.99234.figure5

DOI: 10.3897/phytokeys.221.99234.suppl1

DOI: 10.3897/phytokeys.221.99234.suppl2

DOI: 10.3897/phytokeys.221.99234.suppl3

DOI: 10.3897/phytokeys.221.99234.suppl4

DOI: 10.3897/phytokeys.221.99234.suppl5

DOI: 10.3897/phytokeys.221.99234.suppl6

Language: Unknown

Publisher: Pensoft Publishers

Publication Date: 2023

detail.hit.zdb_id: 2579891-1

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Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries

Glasbey, James C ; Abbott, Tom EF ; Ademuyiwa, Adesoji ; [et al.]

Elsevier BV ; 2022

In: The Lancet Vol. 400, No. 10363 ( 2022-11), p. 1607-1617

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In: The Lancet, Elsevier BV, Vol. 400, No. 10363 ( 2022-11), p. 1607-1617

Type of Medium: Online Resource

ISSN: 0140-6736

URL: Article

DOI: 10.1016/S0140-6736(22)01846-3

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2067452-1

detail.hit.zdb_id: 3306-6

detail.hit.zdb_id: 1476593-7

SSG: 5,21

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Validation of the RIM Score-COVID in the Spanish SEMI-COVID-19 Registry

Ramos-Rincón, José-Manuel ; Ventura, Paula Sol ; Casas-Rojo, José-Manuel ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Internal and Emergency Medicine Vol. 18, No. 3 ( 2023-04), p. 907-915

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In: Internal and Emergency Medicine, Springer Science and Business Media LLC, Vol. 18, No. 3 ( 2023-04), p. 907-915

Type of Medium: Online Resource

ISSN: 1828-0447 , 1970-9366

URL: Article

DOI: 10.1007/s11739-023-03200-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2378342-4

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Mortality reduction in older COVID-19-patients hospitalized in Spain during the second pandemic wave from the SEMI-COVID-19 Registry

Casas-Rojo, José-Manuel ; Antón-Santos, Juan-Miguel ; Millán-Núñez-Cortés, Jesús ; [et al.]

Springer Science and Business Media LLC ; 2023

In: Scientific Reports Vol. 13, No. 1 ( 2023-10-18)

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In: Scientific Reports, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2023-10-18)

Abstract: In 2020, the COVID-19 pandemic followed a two-wave pattern in most countries. Hospital admission for COVID-19 in one wave or another could have affected mortality, especially among the older persons. The objective of this study was to evaluate whether the admission of older patients during the different waves, before SARS-CoV-2 vaccination was available, was associated with a different mortality. We compared the mortality rates of patients hospitalized during 2020 before (first wave) and after (second wave) July 7, 2020, included in the SEMI-COVID-19 Registry, a large, multicenter, retrospective cohort of patients admitted to 126 Spanish hospitals for COVID-19. A multivariate logistic regression analysis was performed to control for changes in either the patient or disease profile. As of December 26, 2022, 22,494 patients had been included (17,784 from the first wave and 4710 from the second one). Overall mortality was 20.4% in the first wave and 17.2% in the second wave (risk difference (RD) − 3.2%; 95% confidence interval (95% CI) − 4.4 to − 2.0). Only patients aged 70 and older (10,973 patients: 8571 in the first wave and 2386 in the second wave) had a significant reduction in mortality (RD − 7.6%; 95% CI − 9.7 to − 5.5) (unadjusted relative risk reduction: 21.6%). After adjusting for age, comorbidities, variables related to the severity of the disease, and treatment received, admission during the second wave remained a protective factor. In Spain, patients aged 70 years and older admitted during the second wave of the COVID-19 pandemic had a significantly lower risk of mortality, except in severely dependent persons in need of corticosteroid treatment. This effect is independent of patient characteristics, disease severity, or treatment received. This suggests a protective effect of a better standard of care, greater clinical expertise, or a lesser degree of healthcare system overload.

Type of Medium: Online Resource

ISSN: 2045-2322

URL: Article

DOI: 10.1038/s41598-023-42735-5

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2023

detail.hit.zdb_id: 2615211-3

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Access to and quality of elective care: a prospective cohort study using hernia surgery as a tracer condition in 83 countries

Dönmez, A Eylül ; Goswami, Aakansha Giri ; Raheja, Aashna ; [et al.]

Elsevier BV ; 2024

In: The Lancet Global Health Vol. 12, No. 7 ( 2024-07), p. e1094-e1103

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In: The Lancet Global Health, Elsevier BV, Vol. 12, No. 7 ( 2024-07), p. e1094-e1103

Type of Medium: Online Resource

ISSN: 2214-109X

URL: Article

DOI: 10.1016/S2214-109X(24)00142-6

Language: English

Publisher: Elsevier BV

Publication Date: 2024

detail.hit.zdb_id: 2723488-5

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Effectiveness and safety of first-line antiretroviral regimens in clinical practice: a multicentre cohort study

Alejos, Belén ; Suárez-García, Inés ; Rava, Marta ; [et al.]

Oxford University Press (OUP) ; 2020

In: Journal of Antimicrobial Chemotherapy Vol. 75, No. 10 ( 2020-10-01), p. 3004-3014

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In: Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), Vol. 75, No. 10 ( 2020-10-01), p. 3004-3014

Abstract: We compared 48 week effectiveness and safety of first-line antiretroviral regimens. Methods We analysed HIV treatment-naive adults from the Cohort of the Spanish HIV/AIDS Research Network (CoRIS) starting the most commonly used antiretroviral regimens from 2014 to 2018. We used multivariable regression models to assess the impact of initial regimen on: (i) viral suppression (VS) (viral load & lt;50 copies/mL); (ii) change in CD4 cell count; (iii) CD4/CD8 normalization ( & gt;0.4 and & gt;1); (iv) CD4 percentage normalization ( & gt;29%); (v) multiple T-cell marker recovery (MTMR: CD4 & gt; 500 cells/mm3 plus CD4 percentage & gt;29% plus CD4/CD8 & gt; 1); (vi) lipid, creatinine and transaminase changes; and (vii) discontinuations due to adverse events (AE). Results Among 3945 individuals analysed, the most frequently prescribed regimens were ABC/3TC/DTG (34.0%), TAF/FTC/EVG/CBT (17.2%), TDF/FTC + DTG (11.9%), TDF/FTC/EVG/CBT (11.7%), TDF/FTC/RPV (11.5%), TDF/FTC + bDRV (8.3%) and TDF/FTC + RAL (5.3%). At 48 weeks, 89.7% of individuals achieved VS with no significant differences by initial regimen. CD4 mean increase was 257.8 (249.3; 266.2) cells/mm3, and it was lower with TAF/FTC/EVG/CBT and TDF/FTC/RPV compared with ABC/3TC/DTG. CD4 percentage normalization was less likely with TAF/FTC/EVG/CBT, and MTMR was less likely with TAF/FTC/EVG/CBT and TDF/FTC + RAL. The proportion of discontinuations due to AE was higher with TDF/FTC + bDRV (9.7%), followed by TDF/FTC/EVG/CBT (9.5%) and TDF/FTC + DTG (7.9%). Compared with ABC/3TC/DTG, cholesterol and LDL mean increases were higher with TAF/FTC/EVG/CBT and lower with TDF/FTC + DTG, TDF/FTC/RPV and TDF/FTC + RAL. Higher mean increases in triglycerides were significantly associated with TAF/FTC/EVG/CBT. Regimens containing DTG showed higher creatinine increases. Conclusions The significantly greater immunological response and safety of some combinations may be useful for making decisions when initiating treatment.

Type of Medium: Online Resource

ISSN: 0305-7453 , 1460-2091

URL: Article

DOI: 10.1093/jac/dkaa246

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2020

detail.hit.zdb_id: 1467478-6

SSG: 15,3

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ESICM LIVES 2016: part three : Milan, Italy. 1–5 October 2016

Velasquez, T. ; GETGAG Working Group ; Mackey, G. ; [et al.]

Springer Science and Business Media LLC ; 2016

In: Intensive Care Medicine Experimental Vol. 4, No. S1 ( 2016-9)

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In: Intensive Care Medicine Experimental, Springer Science and Business Media LLC, Vol. 4, No. S1 ( 2016-9)

Type of Medium: Online Resource

ISSN: 2197-425X

URL: Article

DOI: 10.1186/s40635-016-0100-7

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2016

detail.hit.zdb_id: 2740385-3

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Global variation in postoperative mortality and complications after cancer surgery: a multicentre, prospective cohort study in 82 countries

Knight, Stephen R ; Shaw, Catherine A ; Pius, Riinu ; [et al.]

Elsevier BV ; 2021

In: The Lancet Vol. 397, No. 10272 ( 2021-01), p. 387-397

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In: The Lancet, Elsevier BV, Vol. 397, No. 10272 ( 2021-01), p. 387-397

Type of Medium: Online Resource

ISSN: 0140-6736

URL: Article

DOI: 10.1016/S0140-6736(21)00001-5

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2021

detail.hit.zdb_id: 2067452-1

detail.hit.zdb_id: 3306-6

detail.hit.zdb_id: 1476593-7

SSG: 5,21

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Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Knight, Stephen R ; Shaw, Catherine A ; Pius, Riinu ; [et al.]

Elsevier BV ; 2022

In: The Lancet Global Health Vol. 10, No. 7 ( 2022-07), p. e1003-e1011

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In: The Lancet Global Health, Elsevier BV, Vol. 10, No. 7 ( 2022-07), p. e1003-e1011

Type of Medium: Online Resource

ISSN: 2214-109X

URL: Article

DOI: 10.1016/S2214-109X(22)00168-1

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2723488-5

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Elective Cancer Surgery in COVID-19–Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study

Glasbey, James C. ; Nepogodiev, Dmitri ; Simoes, Joana F.F. ; [et al.]

American Society of Clinical Oncology (ASCO) ; 2021

In: Journal of Clinical Oncology Vol. 39, No. 1 ( 2021-01-01), p. 66-78

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In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 39, No. 1 ( 2021-01-01), p. 66-78

Abstract: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks.

Type of Medium: Online Resource

ISSN: 0732-183X , 1527-7755

URL: Article

DOI: 10.1200/JCO.20.01933

RVK:

XA 52760

RVK:

XA 10000

Language: English

Publisher: American Society of Clinical Oncology (ASCO)

Publication Date: 2021

detail.hit.zdb_id: 2005181-5

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