In:
PLOS ONE, Public Library of Science (PLoS), Vol. 17, No. 5 ( 2022-5-12), p. e0267853-
Abstract:
Prior to direct-acting antivirals (DAAs), HCV incidence rose among men who have sex with men (MSM) living with HIV infection in Germany despite high hepatitis C virus (HCV) treatment rates. We establish a HCV elimination modeling framework to evaluate whether existing treatment rates can achieve the World Health Organization (WHO) incidence target among MSM living with HIV in Germany. Methods To evaluate progress towards HCV elimination in Germany, we adapted a previously published HCV transmission model among MSM living with diagnosed HIV. We modelled HCV incidence and prevalence until 2030 (relative to 2015) under existing treatment and DAA scale-up and explored potential impacts of disruptions in treatment and behavioral risk reduction due to the COVID-19 pandemic. Results Continuing current treatment rates will result in stable HCV incidence among MSM living with HIV in Germany between 2015–2030. The WHO HCV incidence target is achievable under DAA scale-up to 100% treatment combined with treatment of those previously diagnosed and untreated (at a rate of 15%/year) and would result in greater reductions with early treatment (3 vs 6 months) reducing incidence from 4.0/100person-years to 0.8/100person-years by 2030. A 12-month disruption to HCV treatment (20% reduction) and risk behaviors (25%,50%,75% reduction) during the COVID-19 pandemic would result in a 15% relative increase in total HCV incidence in 2030 compared to that expected under the status quo. Conclusions HCV elimination among MSM living with HIV in Germany requires further DAA scale-up among those newly diagnosed combined with efforts to treat those previously diagnosed but untreated. Prospective monitoring will establish whether Germany is on track for HCV microelimination.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0267853
DOI:
10.1371/journal.pone.0267853.g001
DOI:
10.1371/journal.pone.0267853.g002
DOI:
10.1371/journal.pone.0267853.g003
DOI:
10.1371/journal.pone.0267853.g004
DOI:
10.1371/journal.pone.0267853.t001
DOI:
10.1371/journal.pone.0267853.s001
DOI:
10.1371/journal.pone.0267853.s002
DOI:
10.1371/journal.pone.0267853.s003
DOI:
10.1371/journal.pone.0267853.s004
DOI:
10.1371/journal.pone.0267853.s005
DOI:
10.1371/journal.pone.0267853.s006
DOI:
10.1371/journal.pone.0267853.s007
DOI:
10.1371/journal.pone.0267853.s008
DOI:
10.1371/journal.pone.0267853.r001
DOI:
10.1371/journal.pone.0267853.r002
DOI:
10.1371/journal.pone.0267853.r003
DOI:
10.1371/journal.pone.0267853.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2022
detail.hit.zdb_id:
2267670-3
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