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ZFP423 Coordinates Notch and Bone Morphogenetic Protein Signaling, Selectively Up-regulating Hes5 Gene Expression

Masserdotti, Giacomo ; Badaloni, Aurora ; Green, Yangsook Song ; [et al.]

Elsevier BV ; 2010

In: Journal of Biological Chemistry Vol. 285, No. 40 ( 2010-10), p. 30814-30824

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In: Journal of Biological Chemistry, Elsevier BV, Vol. 285, No. 40 ( 2010-10), p. 30814-30824

Type of Medium: Online Resource

ISSN: 0021-9258

URL: Article

DOI: 10.1074/jbc.M110.142869

Language: English

Publisher: Elsevier BV

Publication Date: 2010

detail.hit.zdb_id: 2141744-1

detail.hit.zdb_id: 1474604-9

SSG: 12

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A key role for the HLH transcription factor EBF2COE2,O/E-3 in Purkinje neuron migration and cerebellar cortical topography

Croci, Laura ; Chung, Seung-Hyuk ; Masserdotti, Giacomo ; [et al.]

The Company of Biologists ; 2006

In: Development Vol. 133, No. 14 ( 2006-07-15), p. 2719-2729

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In: Development, The Company of Biologists, Vol. 133, No. 14 ( 2006-07-15), p. 2719-2729

Abstract: Early B-cell factor 2 (EBF2) is one of four mammalian members of an atypical helix-loop-helix transcription factor family (COE). COE proteins have been implicated in various aspects of nervous and immune system development. We and others have generated and described mice carrying a null mutation of Ebf2, a gene previously characterized in the context of Xenopus laevis primary neurogenesis and neuronal differentiation. In addition to deficits in neuroendocrine and olfactory development, and peripheral nerve maturation, Ebf2 null mice feature an ataxic gait and obvious motor deficits associated with clear-cut abnormalities of cerebellar development. The number of Purkinje cells (PCs) in the Ebf2 null is markedly decreased, resulting in a small cerebellum with notable foliation defects,particularly in the anterior vermis. We show that this stems from the defective migration of a molecularly defined PC subset that subsequently dies by apoptosis. Part of the striped cerebellar topography is disrupted due to cell death and, in addition, many of the surviving PCs, that would normally adopt a zebrin II-negative phenotype, transdifferentiate to Zebrin II-positive, an unprecedented finding suggesting that Ebf2 is required for the establishment of a proper cerebellar cortical map.

Type of Medium: Online Resource

ISSN: 1477-9129 , 0950-1991

URL: Article

DOI: 10.1242/dev.02437

Language: English

Publisher: The Company of Biologists

Publication Date: 2006

detail.hit.zdb_id: 2007916-3

SSG: 12

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Direct neuronal reprogramming: learning from and for development

Masserdotti, Giacomo ; Gascón, Sergio ; Götz, Magdalena

The Company of Biologists ; 2016

In: Development Vol. 143, No. 14 ( 2016-07-15), p. 2494-2510

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In: Development, The Company of Biologists, Vol. 143, No. 14 ( 2016-07-15), p. 2494-2510

Abstract: The key signalling pathways and transcriptional programmes that instruct neuronal diversity during development have largely been identified. In this Review, we discuss how this knowledge has been used to successfully reprogramme various cell types into an amazing array of distinct types of functional neurons. We further discuss the extent to which direct neuronal reprogramming recapitulates embryonic development, and examine the particular barriers to reprogramming that may exist given a cell's unique developmental history. We conclude with a recently proposed model for cell specification called the ‘Cook Islands’ model, and consider whether it is a fitting model for cell specification based on recent results from the direct reprogramming field.

Type of Medium: Online Resource

ISSN: 1477-9129 , 0950-1991

URL: Article

DOI: 10.1242/dev.092163

Language: English

Publisher: The Company of Biologists

Publication Date: 2016

detail.hit.zdb_id: 2007916-3

SSG: 12

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Directing Astroglia from the Cerebral Cortex into Subtype Specific Functional Neurons

Heinrich, Christophe ; Blum, Robert ; Gascón, Sergio ; [et al.]

Public Library of Science (PLoS) ; 2010

In: PLoS Biology Vol. 8, No. 5 ( 2010-5-18), p. e1000373-

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In: PLoS Biology, Public Library of Science (PLoS), Vol. 8, No. 5 ( 2010-5-18), p. e1000373-

Type of Medium: Online Resource

ISSN: 1545-7885

URL: Article

DOI: 10.1371/journal.pbio.1000373

DOI: 10.1371/journal.pbio.1000373.g001

DOI: 10.1371/journal.pbio.1000373.g002

DOI: 10.1371/journal.pbio.1000373.g003

DOI: 10.1371/journal.pbio.1000373.g004

DOI: 10.1371/journal.pbio.1000373.g005

DOI: 10.1371/journal.pbio.1000373.g006

DOI: 10.1371/journal.pbio.1000373.g007

DOI: 10.1371/journal.pbio.1000373.g008

DOI: 10.1371/journal.pbio.1000373.g009

DOI: 10.1371/journal.pbio.1000373.g010

DOI: 10.1371/journal.pbio.1000373.g011

DOI: 10.1371/journal.pbio.1000373.g012

DOI: 10.1371/journal.pbio.1000373.g013

DOI: 10.1371/journal.pbio.1000373.g014

DOI: 10.1371/journal.pbio.1000373.g015

DOI: 10.1371/journal.pbio.1000373.s001

DOI: 10.1371/journal.pbio.1000373.s002

DOI: 10.1371/journal.pbio.1000373.s003

DOI: 10.1371/journal.pbio.1000373.s004

DOI: 10.1371/journal.pbio.1000373.s005

DOI: 10.1371/journal.pbio.1000373.s006

DOI: 10.1371/journal.pbio.1000373.s007

DOI: 10.1371/journal.pbio.1000373.s008

DOI: 10.1371/journal.pbio.1000373.s009

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2010

detail.hit.zdb_id: 2126773-X

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Probing cell identity hierarchies by fate titration and collision during direct reprogramming

Hersbach, Bob A ; Fischer, David S ; Masserdotti, Giacomo ; [et al.]

EMBO ; 2022

In: Molecular Systems Biology Vol. 18, No. 9 ( 2022-09)

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In: Molecular Systems Biology, EMBO, Vol. 18, No. 9 ( 2022-09)

Type of Medium: Online Resource

ISSN: 1744-4292 , 1744-4292

URL: Article

DOI: 10.15252/msb.202211129

Language: English

Publisher: EMBO

Publication Date: 2022

detail.hit.zdb_id: 2193510-5

SSG: 12

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Oligodendrogliogenic and neurogenic adult subependymal zone neural stem cells constitute distinct lineages and exhibit differential responsiveness to Wnt signalling

Ortega, Felipe ; Gascón, Sergio ; Masserdotti, Giacomo ; [et al.]

Springer Science and Business Media LLC ; 2013

In: Nature Cell Biology Vol. 15, No. 6 ( 2013-06), p. 602-613

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In: Nature Cell Biology, Springer Science and Business Media LLC, Vol. 15, No. 6 ( 2013-06), p. 602-613

Type of Medium: Online Resource

ISSN: 1465-7392 , 1476-4679

URL: Article

DOI: 10.1038/ncb2736

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2013

detail.hit.zdb_id: 1494945-3

SSG: 12

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SoxC Transcription Factors Are Required for Neuronal Differentiation in Adult Hippocampal Neurogenesis

Mu, Lifang ; Berti, Lucia ; Masserdotti, Giacomo ; [et al.]

Society for Neuroscience ; 2012

In: The Journal of Neuroscience Vol. 32, No. 9 ( 2012-02-29), p. 3067-3080

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In: The Journal of Neuroscience, Society for Neuroscience, Vol. 32, No. 9 ( 2012-02-29), p. 3067-3080

Abstract: Neural stem cells (NSCs) generate new hippocampal dentate granule neurons throughout adulthood. The genetic programs controlling neuronal differentiation of adult NSCs are only poorly understood. Here we show that, in the adult mouse hippocampus, expression of the SoxC transcription factors Sox4 and Sox11 is initiated around the time of neuronal commitment of adult NSCs and is maintained in immature neurons. Overexpression of Sox4 and Sox11 strongly promotes in vitro neurogenesis from adult NSCs, whereas ablation of Sox4/Sox11 prevents in vitro and in vivo neurogenesis from adult NSCs. Moreover, we demonstrate that SoxC transcription factors target the promoters of genes that are induced on neuronal differentiation of adult NSCs. Finally, we show that reprogramming of astroglia into neurons is dependent on the presence of SoxC factors. These data identify SoxC proteins as essential contributors to the genetic network controlling neuronal differentiation in adult neurogenesis and neuronal reprogramming of somatic cells.

Type of Medium: Online Resource

ISSN: 0270-6474 , 1529-2401

URL: Article

DOI: 10.1523/JNEUROSCI.4679-11.2012

Language: English

Publisher: Society for Neuroscience

Publication Date: 2012

detail.hit.zdb_id: 1475274-8

SSG: 12

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A Critical Period for Experience-Dependent Remodeling of Adult-Born Neuron Connectivity

Bergami, Matteo ; Masserdotti, Giacomo ; Temprana, Silvio G. ; [et al.]

Elsevier BV ; 2015

In: Neuron Vol. 85, No. 4 ( 2015-02), p. 710-717

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In: Neuron, Elsevier BV, Vol. 85, No. 4 ( 2015-02), p. 710-717

Type of Medium: Online Resource

ISSN: 0896-6273

URL: Article

DOI: 10.1016/j.neuron.2015.01.001

Language: English

Publisher: Elsevier BV

Publication Date: 2015

detail.hit.zdb_id: 2001944-0

SSG: 12

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Direct neuronal reprogramming: Fast forward from new concepts toward therapeutic approaches

Bocchi, Riccardo ; Masserdotti, Giacomo ; Götz, Magdalena

Elsevier BV ; 2022

In: Neuron Vol. 110, No. 3 ( 2022-02), p. 366-393

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In: Neuron, Elsevier BV, Vol. 110, No. 3 ( 2022-02), p. 366-393

Type of Medium: Online Resource

ISSN: 0896-6273

URL: Article

DOI: 10.1016/j.neuron.2021.11.023

Language: English

Publisher: Elsevier BV

Publication Date: 2022

detail.hit.zdb_id: 2001944-0

SSG: 12

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Identification and Successful Negotiation of a Metabolic Checkpoint in Direct Neuronal Reprogramming

Gascón, Sergio ; Murenu, Elisa ; Masserdotti, Giacomo ; [et al.]

Elsevier BV ; 2016

In: Cell Stem Cell Vol. 18, No. 3 ( 2016-03), p. 396-409

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In: Cell Stem Cell, Elsevier BV, Vol. 18, No. 3 ( 2016-03), p. 396-409

Type of Medium: Online Resource

ISSN: 1934-5909

URL: Article

DOI: 10.1016/j.stem.2015.12.003

Language: English

Publisher: Elsevier BV

Publication Date: 2016

detail.hit.zdb_id: 2375356-0

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