In:
International Journal of Cancer, Wiley, Vol. 146, No. 9 ( 2020-05), p. 2460-2474
Abstract:
What's new? Infection with human papilloma virus (HPV) generally lowers risk of death for patients with oropharyngeal squamous cell carcinoma but 20% of patients do not “benefit” from HPV infection in this sense. Here the authors used DNA methylome analysis to further subdivide HPV+ and HPV‐ cancer patients, successfully recapitulating the distinct prognosis. They also generated classifier markers to accurately distinguish between subtypes based on epigenome analysis, but not genomic mutations, thus potentially aiding with clinical treatment decisions in the future.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2020
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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