In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 72, No. 8_Supplement ( 2012-04-15), p. 3406-3406
Abstract:
Epithelial-Mesenchymal transition (EMT) plays a critical role in cancer progression and metastasis. However, whether the overexpression of EMT-related genes mediates the malignant phenotype in HCC remains largely unclear. In this study, we examined the relationship between mRNA expression levels of EMT-related genesand 12 clinical characteristics including recurrence-free survival and overall survival in HCC patients who had undergone curative hepatic resection. The mRNA expression levels of 15 genes (CDH1, CDH2, Snail, Slug, ZEB1, ZEB2, TWIST, Vimentin, Fibronectin, DDR2, S100A4, TJP-1/ZO-1, FOXC2, SIX1, GSC) was determined by quantitative real-time PCR in tissues from 72 HCC tumors. Twist expression was significantly upregulated in recurrence group (p=0.02). The upregulation of Twist and the downregulation of TJP1 were significantly related with poor prognosis in univariate and multivariate analysis. In conclusion, Twist and TJP1 may be predictive biomarkers in patients with HCC after hepatectomy. Our findings provide a novel insight into TJP1 and HCC, warranting further investigations. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 3406. doi:1538-7445.AM2012-3406
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.AM2012-3406
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2012
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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