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Acquired resistance to temsirolimus is associated with integrin α7 driven chemotactic activity of renal cell carcinoma in vitro

Engl, Tobias ; Rutz, Jochen ; Maxeiner, Sebastian ; [et al.]

Impact Journals, LLC ; 2018

In: Oncotarget Vol. 9, No. 27 ( 2018-04-10), p. 18747-18759

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In: Oncotarget, Impact Journals, LLC, Vol. 9, No. 27 ( 2018-04-10), p. 18747-18759

Type of Medium: Online Resource

ISSN: 1949-2553

URL: Issue

URL: Article

DOI: 10.18632/oncotarget.v9i27

DOI: 10.18632/oncotarget.24650

Language: English

Publisher: Impact Journals, LLC

Publication Date: 2018

detail.hit.zdb_id: 2560162-3

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An accelerated dual method based on analytical extrapolation for distributed quadratic optimization of large-scale production complexes

Maxeiner, Lukas Samuel ; Engell, Sebastian

Elsevier BV ; 2020

In: Computers & Chemical Engineering Vol. 135 ( 2020-04), p. 106728-

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In: Computers & Chemical Engineering, Elsevier BV, Vol. 135 ( 2020-04), p. 106728-

Type of Medium: Online Resource

ISSN: 0098-1354

URL: Article

DOI: 10.1016/j.compchemeng.2020.106728

Language: English

Publisher: Elsevier BV

Publication Date: 2020

detail.hit.zdb_id: 1499971-7

detail.hit.zdb_id: 754954-4

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HDAC Inhibition Counteracts Metastatic Re-Activation of Prostate Cancer Cells Induced by Chronic mTOR Suppression

Makarević, Jasmina ; Rutz, Jochen ; Juengel, Eva ; [et al.]

MDPI AG ; 2018

In: Cells Vol. 7, No. 9 ( 2018-09-01), p. 129-

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In: Cells, MDPI AG, Vol. 7, No. 9 ( 2018-09-01), p. 129-

Abstract: This study was designed to investigate whether epigenetic modulation by histone deacetylase (HDAC) inhibition might circumvent resistance towards the mechanistic target of rapamycin (mTOR) inhibitor temsirolimus in a prostate cancer cell model. Parental (par) and temsirolimus-resistant (res) PC3 prostate cancer cells were exposed to the HDAC inhibitor valproic acid (VPA), and tumor cell adhesion, chemotaxis, migration, and invasion were evaluated. Temsirolimus resistance was characterized by reduced binding of PC3res cells to endothelium, immobilized collagen, and fibronectin, but increased adhesion to laminin, as compared to the parental cells. Chemotaxis, migration, and invasion of PC3res cells were enhanced following temsirolimus re-treatment. Integrin α and β receptors were significantly altered in PC3res compared to PC3par cells. VPA significantly counteracted temsirolimus resistance by down-regulating tumor cell–matrix interaction, chemotaxis, and migration. Evaluation of integrin expression in the presence of VPA revealed a significant down-regulation of integrin α5 in PC3res cells. Blocking studies demonstrated a close association between α5 expression on PC3res and chemotaxis. In this in vitro model, temsirolimus resistance drove prostate cancer cells to become highly motile, while HDAC inhibition reversed the metastatic activity. The VPA-induced inhibition of metastatic activity was accompanied by a lowered integrin α5 surface level on the tumor cells.

Type of Medium: Online Resource

ISSN: 2073-4409

URL: Article

DOI: 10.3390/cells7090129

Language: English

Publisher: MDPI AG

Publication Date: 2018

detail.hit.zdb_id: 2661518-6

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Sulforaphane Reduces Prostate Cancer Cell Growth and Proliferation In Vitro by Modulating the Cdk-Cyclin Axis and Expression of the CD44 Variants 4, 5, and 7

Rutz, Jochen ; Thaler, Sarah ; Maxeiner, Sebastian ; [et al.]

MDPI AG ; 2020

In: International Journal of Molecular Sciences Vol. 21, No. 22 ( 2020-11-18), p. 8724-

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In: International Journal of Molecular Sciences, MDPI AG, Vol. 21, No. 22 ( 2020-11-18), p. 8724-

Abstract: Prostate cancer patients whose tumors develop resistance to conventional treatment often turn to natural, plant-derived products, one of which is sulforaphane (SFN). This study was designed to determine whether anti-tumor properties of SFN, identified in other tumor entities, are also evident in cultivated DU145 and PC3 prostate cancer cells. The cells were incubated with SFN (1–20 µM) and tumor cell growth and proliferative activity were evaluated. Having found a considerable anti-growth, anti-proliferative, and anti-clonogenic influence of SFN on both prostate cancer cell lines, further investigation into possible mechanisms of action were performed by evaluating the cell cycle phases and cell-cycle-regulating proteins. SFN induced a cell cycle arrest at the S- and G2/M-phase in both DU145 and PC3 cells. Elevation of histone H3 and H4 acetylation was also evident in both cell lines following SFN exposure. However, alterations occurring in the Cdk-cyclin axis, modification of the p19 and p27 proteins and changes in CD44v4, v5, and v7 expression because of SFN exposure differed in the two cell lines. SFN, therefore, does exert anti-tumor properties on these two prostate cancer cell lines by histone acetylation and altering the intracellular signaling cascade, but not through the same molecular mechanisms.

Type of Medium: Online Resource

ISSN: 1422-0067

URL: Article

DOI: 10.3390/ijms21228724

Language: English

Publisher: MDPI AG

Publication Date: 2020

detail.hit.zdb_id: 2019364-6

SSG: 12

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Primary magnetic resonance imaging/ultrasonography fusion‐guided biopsy of the prostate

Maxeiner, Andreas ; Kittner, Beatrice ; Blobel, Conrad ; [et al.]

Wiley ; 2018

In: BJU International Vol. 122, No. 2 ( 2018-08), p. 211-218

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In: BJU International, Wiley, Vol. 122, No. 2 ( 2018-08), p. 211-218

Abstract: To examine the performance of a primary magnetic resonance imaging ( MRI )/ultrasonography ( US ) fusion‐guided targeted biopsy ( TB ), and in combination with an added systematic biopsy ( SB ). Patients and Methods Analysis of 318 consecutive biopsy‐naïve men with suspicious multiparametric MRI (mp MRI ; Prostate Imaging Reporting and Data System [ PI ‐ RADS ] score ≥3) undergoing transrectal TB and 10‐core SB between January 2012 and December 2016. The indication for performing mp MRI was based on clinical parameters and decided by the treating urologist before admission. TB was performed with a sensor‐based MRI / US fusion‐guided platform. Clinically significant prostate cancer was defined as Gleason score ≥4 + 3 = 7 (International Society of Urological Pathology Grade [ ISUP ] grade 3) or maximum cancer core length of ≥6 mm. Results A median (interquartile range) of 14 (13–14) biopsies per case were taken. The overall cancer detection rate ( CDR ) was 77% (245/318). The TB alone detected 67% of prostate cancers and the SB alone detected 70%. The PI ‐ RADS dependent CDR for the combination of TB / SB were 38% (21/55), 78% (120/154) and 95% (104/109) for PI ‐ RADS scores of 3/4/5, respectively. Clinically significant prostate cancer was diagnosed by the combination of TB and SB in 195 men (61%) and by TB alone in 163 cases (51%). The number of missed or underestimated prostate cancers with a Gleason score ≥8 for TB alone was 31 (10%, P 〈 0.001) and 21 (7%, P 〈 0.001) for SB alone in comparison with the results of the combination of TB and SB . The rate of insignificant prostate cancer was comparable for the combination of TB and SB and TB alone (50/318, 16% vs 50/318, 16%). Conclusions Pre‐biopsy mp MRI is of incremental value in increasing the detection of clinically significant prostate cancer in biopsy‐naïve patients with suspicion of prostate cancer. Combining TB with SB further improved the diagnostic accuracy without increasing the rate of insignificant prostate cancer.

Type of Medium: Online Resource

ISSN: 1464-4096 , 1464-410X

URL: Issue

URL: Article

DOI: 10.1111/bju.2018.122.issue-2

DOI: 10.1111/bju.14212

Language: English

Publisher: Wiley

Publication Date: 2018

detail.hit.zdb_id: 2019983-1

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Deciphering the Molecular Machinery—Influence of sE-Cadherin on Tumorigenic Traits of Prostate Cancer Cells

Tsaur, Igor ; Thomas, Anita ; Juengel, Eva ; [et al.]

MDPI AG ; 2021

In: Biology Vol. 10, No. 10 ( 2021-10-07), p. 1007-

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In: Biology, MDPI AG, Vol. 10, No. 10 ( 2021-10-07), p. 1007-

Abstract: The serum level of soluble (s)E-cadherin is elevated in several malignancies, including prostate cancer (PCa). This study was designed to investigate the effects of sE-cadherin on the behavior of PCa cells in vitro, with the aim of identifying a potential therapeutic target. Growth as well as adhesive and motile behavior were evaluated in PC3, DU-145, and LNCaP cells. Flow cytometry was used to assess cell cycle phases and the surface expression of CD44 variants as well as α and β integrins. Confocal microscopy was utilized to visualize the distribution of CD44 variants within the cells. Western blot was applied to investigate expression of α3 and β1 integrins as well as cytoskeletal and adhesion proteins. Cell growth was significantly inhibited after exposure to 5 µg/mL sE-cadherin and was accompanied by a G0/G1-phase arrest. Adhesion of cells to collagen and fibronectin was mitigated, while motility was augmented. CD44v4, v5, and v7 expression was elevated while α3 and β1 integrins were attenuated. Blocking integrin α3 reduced cell growth and adhesion to collagen but increased motility. sE-cadherin therefore appears to foster invasive tumor cell behavior, and targeting it might serve as a novel and innovative concept to treat advanced PCa.

Type of Medium: Online Resource

ISSN: 2079-7737

URL: Article

DOI: 10.3390/biology10101007

Language: English

Publisher: MDPI AG

Publication Date: 2021

detail.hit.zdb_id: 2661517-4

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Hierarchical MPC of batch reactors with shared resources * *The work leading to this publication has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 723575 (CoPro, spire2030.eu/copro) in the framework of the SPIRE PPP and it has received funding under the grant agreement No 611281 (FP7 ICT project DYMASOS, dymasos.eu).

Maxeiner, Lukas S. ; Engell, Sebastian

Elsevier BV ; 2017

In: IFAC-PapersOnLine Vol. 50, No. 1 ( 2017-07), p. 12041-12046

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In: IFAC-PapersOnLine, Elsevier BV, Vol. 50, No. 1 ( 2017-07), p. 12041-12046

Type of Medium: Online Resource

ISSN: 2405-8963

URL: Article

DOI: 10.1016/j.ifacol.2017.08.2103

Language: English

Publisher: Elsevier BV

Publication Date: 2017

detail.hit.zdb_id: 2839185-8

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Sulforaphane inhibits proliferation and invasive activity of everolimus-resistant kidney cancer cells in vitro

Juengel, Eva ; Maxeiner, Sebastian ; Rutz, Jochen ; [et al.]

Impact Journals, LLC ; 2016

In: Oncotarget Vol. 7, No. 51 ( 2016-12-20), p. 85208-85219

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In: Oncotarget, Impact Journals, LLC, Vol. 7, No. 51 ( 2016-12-20), p. 85208-85219

Type of Medium: Online Resource

ISSN: 1949-2553

URL: Issue

URL: Article

DOI: 10.18632/oncotarget.v7i51

DOI: 10.18632/oncotarget.13421

Language: English

Publisher: Impact Journals, LLC

Publication Date: 2016

detail.hit.zdb_id: 2560162-3

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Amygdalin Modulates Prostate Cancer Cell Adhesion and Migration In Vitro

Mani, Jens ; Neuschäfer, Jens ; Resch, Christian ; [et al.]

Informa UK Limited ; 2020

In: Nutrition and Cancer Vol. 72, No. 3 ( 2020-04-02), p. 528-537

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In: Nutrition and Cancer, Informa UK Limited, Vol. 72, No. 3 ( 2020-04-02), p. 528-537

Type of Medium: Online Resource

ISSN: 0163-5581 , 1532-7914

URL: Article

DOI: 10.1080/01635581.2019.1637442

Language: English

Publisher: Informa UK Limited

Publication Date: 2020

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Coincident airway exposure to low-potency allergen and cytomegalovirus sensitizes for allergic airway disease by viral activation of migratory dendritic cells

Reuter, Sebastian ; Lemmermann, Niels A. W. ; Maxeiner, Joachim ; [et al.]

Public Library of Science (PLoS) ; 2019

In: PLOS Pathogens Vol. 15, No. 3 ( 2019-3-7), p. e1007595-

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In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 15, No. 3 ( 2019-3-7), p. e1007595-

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1007595

DOI: 10.1371/journal.ppat.1007595.g001

DOI: 10.1371/journal.ppat.1007595.g002

DOI: 10.1371/journal.ppat.1007595.g003

DOI: 10.1371/journal.ppat.1007595.g004

DOI: 10.1371/journal.ppat.1007595.g005

DOI: 10.1371/journal.ppat.1007595.g006

DOI: 10.1371/journal.ppat.1007595.g007

DOI: 10.1371/journal.ppat.1007595.g008

DOI: 10.1371/journal.ppat.1007595.g009

DOI: 10.1371/journal.ppat.1007595.g010

DOI: 10.1371/journal.ppat.1007595.g011

DOI: 10.1371/journal.ppat.1007595.t001

DOI: 10.1371/journal.ppat.1007595.s001

DOI: 10.1371/journal.ppat.1007595.s002

DOI: 10.1371/journal.ppat.1007595.s003

DOI: 10.1371/journal.ppat.1007595.s004

DOI: 10.1371/journal.ppat.1007595.s005

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2019

detail.hit.zdb_id: 2205412-1

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