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Changes of the Membrane Lipid Organization Characterized by Means of a New Cholesterol-Pyrene Probe

Le Guyader, Laurent ; Le Roux, Christophe ; Mazères, Serge ; [et al.]

Elsevier BV ; 2007

In: Biophysical Journal Vol. 93, No. 12 ( 2007-12), p. 4462-4473

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In: Biophysical Journal, Elsevier BV, Vol. 93, No. 12 ( 2007-12), p. 4462-4473

Type of Medium: Online Resource

ISSN: 0006-3495

URL: Article

DOI: 10.1529/biophysj.107.112821

Language: English

Publisher: Elsevier BV

Publication Date: 2007

detail.hit.zdb_id: 1477214-0

SSG: 12

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Rv0180c contributes to Mycobacterium tuberculosis cell shape and to infectivity in mice and macrophages

Payros, Delphine ; Alonso, Henar ; Malaga, Wladimir ; [et al.]

Public Library of Science (PLoS) ; 2021

In: PLOS Pathogens Vol. 17, No. 11 ( 2021-11-1), p. e1010020-

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In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 17, No. 11 ( 2021-11-1), p. e1010020-

Abstract: Mycobacterium tuberculosis , the main causative agent of human tuberculosis, is transmitted from person to person via small droplets containing very few bacteria. Optimizing the chance to seed in the lungs is therefore a major adaptation to favor survival and dissemination in the human population. Here we used TnSeq to identify genes important for the early events leading to bacterial seeding in the lungs. Beside several genes encoding known virulence factors, we found three new candidates not previously described: rv0180c , rv1779c and rv1592c . We focused on the gene, rv0180c , of unknown function. First, we found that deletion of rv0180c in M . tuberculosis substantially reduced the initiation of infection in the lungs of mice. Next, we established that Rv0180c enhances entry into macrophages through the use of complement-receptor 3 (CR3), a major phagocytic receptor for M . tuberculosis . Silencing CR3 or blocking the CR3 lectin site abolished the difference in entry between the wild-type parental strain and the Δ rv0180c :: km mutant. However, we detected no difference in the production of both CR3-known carbohydrate ligands (glucan, arabinomannan, mannan), CR3-modulating lipids (phthiocerol dimycocerosate), or proteins in the capsule of the Δ rv0180c :: km mutant in comparison to the wild-type or complemented strains. By contrast, we established that Rv0180c contributes to the functionality of the bacterial cell envelope regarding resistance to toxic molecule attack and cell shape. This alteration of bacterial shape could impair the engagement of membrane receptors that M . tuberculosis uses to invade host cells, and open a new perspective on the modulation of bacterial infectivity.

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1010020

DOI: 10.1371/journal.ppat.1010020.g001

DOI: 10.1371/journal.ppat.1010020.g002

DOI: 10.1371/journal.ppat.1010020.g003

DOI: 10.1371/journal.ppat.1010020.g004

DOI: 10.1371/journal.ppat.1010020.g005

DOI: 10.1371/journal.ppat.1010020.g006

DOI: 10.1371/journal.ppat.1010020.g007

DOI: 10.1371/journal.ppat.1010020.s001

DOI: 10.1371/journal.ppat.1010020.s002

DOI: 10.1371/journal.ppat.1010020.s003

DOI: 10.1371/journal.ppat.1010020.s004

DOI: 10.1371/journal.ppat.1010020.s005

DOI: 10.1371/journal.ppat.1010020.s006

DOI: 10.1371/journal.ppat.1010020.s007

DOI: 10.1371/journal.ppat.1010020.s008

DOI: 10.1371/journal.ppat.1010020.s009

DOI: 10.1371/journal.ppat.1010020.s010

DOI: 10.1371/journal.ppat.1010020.s011

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2021

detail.hit.zdb_id: 2205412-1

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Probing the influence of the particle in Single Particle Tracking measurements of lipid diffusion

Mascalchi, Patrice ; Haanappel, Evert ; Carayon, Kévin ; [et al.]

Royal Society of Chemistry (RSC) ; 2012

In: Soft Matter Vol. 8, No. 16 ( 2012), p. 4462-

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In: Soft Matter, Royal Society of Chemistry (RSC), Vol. 8, No. 16 ( 2012), p. 4462-

Type of Medium: Online Resource

ISSN: 1744-683X , 1744-6848

URL: Article

DOI: 10.1039/c2sm07018a

Language: English

Publisher: Royal Society of Chemistry (RSC)

Publication Date: 2012

detail.hit.zdb_id: 2191476-X

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Preparation of Tetradentate Copper Chelators as Potential Anti‐Alzheimer Agents

Zhang, Weixin ; Huang, Daya ; Huang, Meijie ; [et al.]

Wiley ; 2018

In: ChemMedChem Vol. 13, No. 7 ( 2018-04-06), p. 684-704

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In: ChemMedChem, Wiley, Vol. 13, No. 7 ( 2018-04-06), p. 684-704

Abstract: The uncontrolled redox activity of metal ions, especially copper, in the brains of patients with Alzheimer's disease (AD) should be considered the origin of intense oxidative damage to neurons in the AD brain. To obtain low‐molecular‐weight copper chelators that act as tetradentate ligands, we designed new compounds based on an 8‐aminoquinoline motif with a lateral chain attached at the 2‐position of the aromatic ring. Some of these new ligands, termed TDMQ for TetraDentate MonoQuinolines, are specific for copper chelation. Full characterization of these ligands is reported, as well as their affinities for Cu II , and their capacities to inhibit oxidative stress induced by copper–amyloids activated by a reductant. Such metal ligands can be considered as potential anti‐AD agents, as they should be able to regulate the homeostasis of copper in brain tissue.

Type of Medium: Online Resource

ISSN: 1860-7179 , 1860-7187

URL: Issue

URL: Article

DOI: 10.1002/cmdc.v13.7

DOI: 10.1002/cmdc.201700734

RVK:

VA 3569

Language: English

Publisher: Wiley

Publication Date: 2018

detail.hit.zdb_id: 2209649-8

SSG: 15,3

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Thioflavin Derivatives as Markers for Amyloid‐β Fibrils: Insights into Structural Features Important for High‐Affinity Binding

Leuma Yona, Rodrigue ; Mazères, Serge ; Faller, Peter ; [et al.]

Wiley ; 2008

In: ChemMedChem Vol. 3, No. 1 ( 2008-01-11), p. 63-66

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In: ChemMedChem, Wiley, Vol. 3, No. 1 ( 2008-01-11), p. 63-66

Type of Medium: Online Resource

ISSN: 1860-7179 , 1860-7187

URL: Issue

URL: Article

DOI: 10.1002/cmdc.v3:1

DOI: 10.1002/cmdc.200700188

RVK:

VA 3569

Language: English

Publisher: Wiley

Publication Date: 2008

detail.hit.zdb_id: 2209649-8

SSG: 15,3

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Corrigendum: Preparation of Tetradentate Copper Chelators as Potential Anti‐Alzheimer Agents

Zhang, Weixin ; Huang, Daya ; Huang, Meijie ; [et al.]

Wiley ; 2019

In: ChemMedChem Vol. 14, No. 19 ( 2019-10-04), p. 1742-1742

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In: ChemMedChem, Wiley, Vol. 14, No. 19 ( 2019-10-04), p. 1742-1742

Type of Medium: Online Resource

ISSN: 1860-7179 , 1860-7187

URL: Issue

URL: Article

DOI: 10.1002/cmdc.v14.19

DOI: 10.1002/cmdc.201900516

RVK:

VA 3569

Language: English

Publisher: Wiley

Publication Date: 2019

detail.hit.zdb_id: 2209649-8

SSG: 15,3

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Natural mutations in the sensor kinase of the PhoPR two-component regulatory system modulate virulence of ancestor-like tuberculosis bacilli

Malaga, Wladimir ; Payros, Delphine ; Meunier, Eva ; [et al.]

Public Library of Science (PLoS) ; 2023

In: PLOS Pathogens Vol. 19, No. 7 ( 2023-7-14), p. e1011437-

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In: PLOS Pathogens, Public Library of Science (PLoS), Vol. 19, No. 7 ( 2023-7-14), p. e1011437-

Abstract: The molecular factors and genetic adaptations that contributed to the emergence of Mycobacterium tuberculosis (MTB) from an environmental Mycobacterium canettii -like ancestor, remain poorly investigated. In MTB , the PhoPR two-component regulatory system controls production and secretion of proteins and lipid virulence effectors. Here, we describe that several mutations, present in phoR of M . canettii relative to MTB , impact the expression of the PhoP regulon and the pathogenicity of the strains. First, we establish a molecular model of PhoR and show that some substitutions found in PhoR of M . canettii are likely to impact the structure and activity of this protein. Second, we show that STB-K, the most attenuated available M . canettii strain, displays lower expression of PhoP-induced genes than MTB . Third, we demonstrate that genetic swapping of the phoPR allele from STB-K with the ortholog from MTB H37Rv enhances expression of PhoP-controlled functions and the capacities of the recombinant strain to colonize human macrophages, the MTB target cells, as well as to cause disease in several mouse infection models. Fourth, we extended these observations to other M . canettii strains and confirm that PhoP-controlled functions are expressed at lower levels in most M . canettii strains than in M . tuberculosis . Our findings suggest that distinct PhoR variants have been selected during the evolution of tuberculosis bacilli, contributing to higher pathogenicity and persistence of MTB in the mammalian host.

Type of Medium: Online Resource

ISSN: 1553-7374

URL: Article

DOI: 10.1371/journal.ppat.1011437

DOI: 10.1371/journal.ppat.1011437.g001

DOI: 10.1371/journal.ppat.1011437.g002

DOI: 10.1371/journal.ppat.1011437.g003

DOI: 10.1371/journal.ppat.1011437.g004

DOI: 10.1371/journal.ppat.1011437.g005

DOI: 10.1371/journal.ppat.1011437.g006

DOI: 10.1371/journal.ppat.1011437.g007

DOI: 10.1371/journal.ppat.1011437.g008

DOI: 10.1371/journal.ppat.1011437.s001

DOI: 10.1371/journal.ppat.1011437.s002

DOI: 10.1371/journal.ppat.1011437.s003

DOI: 10.1371/journal.ppat.1011437.s004

DOI: 10.1371/journal.ppat.1011437.s005

DOI: 10.1371/journal.ppat.1011437.s006

DOI: 10.1371/journal.ppat.1011437.s007

DOI: 10.1371/journal.ppat.1011437.s008

DOI: 10.1371/journal.ppat.1011437.s009

DOI: 10.1371/journal.ppat.1011437.s010

DOI: 10.1371/journal.ppat.1011437.s011

DOI: 10.1371/journal.ppat.1011437.s012

DOI: 10.1371/journal.ppat.1011437.s013

DOI: 10.1371/journal.ppat.1011437.s014

DOI: 10.1371/journal.ppat.1011437.s015

DOI: 10.1371/journal.ppat.1011437.s016

DOI: 10.1371/journal.ppat.1011437.s017

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2023

detail.hit.zdb_id: 2205412-1

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Characterization of M-laurdan, a versatile probe to explore order in lipid membranes

Mazeres, Serge ; Joly, Etienne ; Lopez, Andre ; [et al.]

F1000 Research Ltd ; 2014

In: F1000Research Vol. 3 ( 2014-11-19), p. 172-

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In: F1000Research, F1000 Research Ltd, Vol. 3 ( 2014-11-19), p. 172-

Type of Medium: Online Resource

ISSN: 2046-1402

URL: Journal

URL: Article

DOI: 10.12688/f1000research

DOI: 10.12688/f1000research.4805.2

Language: English

Publisher: F1000 Research Ltd

Publication Date: 2014

detail.hit.zdb_id: 2699932-8

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N-Heterocyclic Carbene-Iridium Complexes as Photosensitizers for In Vitro Photodynamic Therapy to Trigger Non-Apoptotic Cell Death in Cancer Cells

Wang, Xing ; Zhang, Chen ; Madji, Ryma ; [et al.]

MDPI AG ; 2023

In: Molecules Vol. 28, No. 2 ( 2023-01-10), p. 691-

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In: Molecules, MDPI AG, Vol. 28, No. 2 ( 2023-01-10), p. 691-

Abstract: A series of seven novel iridium complexes were synthetized and characterized as potential photosensitizers for photodynamic therapy (PDT) applications. Among them, four complexes were evaluated in vitro for their anti-proliferative activity with and without irradiation on a panel of five cancer cell lines, namely PC-3 (prostate cancer), T24 (bladder cancer), MCF7 (breast cancer), A549 (lung cancer) and HeLa (cervix cancer), and two non-cancerous cell models (NIH-3T3 fibroblasts and MC3T3 osteoblasts). After irradiation at 458 nm, all tested complexes showed a strong selectivity against cancer cells, with a selectivity index (SI) ranging from 8 to 34 compared with non-cancerous cells. The cytotoxic effect of all these complexes was found to be independent of the anti-apoptotic protein Bcl-xL. The compound exhibiting the best selectivity, complex 4a, was selected for further investigations. Complex 4a was mainly localized in the mitochondria. We found that the loss of cell viability and the decrease in ATP and GSH content induced by complex 4a were independent of both Bcl-xL and caspase activation, leading to a non-apoptotic cell death. By counteracting the intrinsic or acquired resistance to apoptosis associated with cancer, complex 4a could be an interesting therapeutic alternative to be studied in preclinical models.

Type of Medium: Online Resource

ISSN: 1420-3049

URL: Article

DOI: 10.3390/molecules28020691

Language: English

Publisher: MDPI AG

Publication Date: 2023

detail.hit.zdb_id: 2008644-1

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Using spectral decomposition of the signals from laurdan-derived probes to evaluate the physical state of membranes in live cells

Mazeres, Serge ; Fereidouni, Farzad ; Joly, Etienne

F1000 Research Ltd ; 2017

In: F1000Research Vol. 6 ( 2017-8-1), p. 763-

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In: F1000Research, F1000 Research Ltd, Vol. 6 ( 2017-8-1), p. 763-

Type of Medium: Online Resource

ISSN: 2046-1402

URL: Journal

URL: Article

DOI: 10.12688/f1000research

DOI: 10.12688/f1000research.11577.2

Language: English

Publisher: F1000 Research Ltd

Publication Date: 2017

detail.hit.zdb_id: 2699932-8

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