In:
PLOS ONE, Public Library of Science (PLoS), Vol. 16, No. 12 ( 2021-12-28), p. e0261179-
Abstract:
Distinct bacterial upper airway microbiota structures have been described in pediatric populations, and relate to risk of respiratory viral infection and, exacerbations of asthma. We hypothesized that distinct nasopharyngeal (NP) microbiota structures exist in pediatric populations, relate to environmental exposures and modify risk of acute sinusitis or upper respiratory infection (URI) in children. Methods Bacterial 16S rRNA profiles from nasopharyngeal swabs (n = 354) collected longitudinally over a one-year period from 58 children, aged four to seven years, were analyzed and correlated with environmental variables, URI, and sinusitis outcomes. Results Variance in nasopharyngeal microbiota composition significantly related to clinical outcomes, participant characteristics and environmental exposures including dominant bacterial genus, season, daycare attendance and tobacco exposure. Four distinct nasopharyngeal microbiota structures (Cluster I-IV) were evident and differed with respect to URI and sinusitis outcomes. These clusters were characteristically either dominated by Moraxella with sparse underlying taxa (Cluster I), comprised of a non-dominated, diverse microbiota (Cluster II), dominated by Alloiococcus/Corynebacterium (Cluster III), or by Haemophilus (Cluster IV). Cluster I was associated with increased risk of URI and sinusitis (RR = 1.18, p = 0.046; RR = 1.25, p = 0.009, respectively) in the population studied. Conclusion In a pediatric population, URI and sinusitis associate with the presence of Moraxella -dominated NP microbiota.
Type of Medium:
Online Resource
ISSN:
1932-6203
DOI:
10.1371/journal.pone.0261179
DOI:
10.1371/journal.pone.0261179.g001
DOI:
10.1371/journal.pone.0261179.g002
DOI:
10.1371/journal.pone.0261179.g003
DOI:
10.1371/journal.pone.0261179.g004
DOI:
10.1371/journal.pone.0261179.t001
DOI:
10.1371/journal.pone.0261179.t002
DOI:
10.1371/journal.pone.0261179.t003
DOI:
10.1371/journal.pone.0261179.t004
DOI:
10.1371/journal.pone.0261179.s001
DOI:
10.1371/journal.pone.0261179.s002
DOI:
10.1371/journal.pone.0261179.s003
DOI:
10.1371/journal.pone.0261179.r001
DOI:
10.1371/journal.pone.0261179.r002
DOI:
10.1371/journal.pone.0261179.r003
DOI:
10.1371/journal.pone.0261179.r004
Language:
English
Publisher:
Public Library of Science (PLoS)
Publication Date:
2021
detail.hit.zdb_id:
2267670-3
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