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Lapses in Care Among Patients Assigned to Ranibizumab for Proliferative Diabetic Retinopathy : A Post Hoc Analysis of a Randomized Clinical Trial

Maguire, Maureen G. ; Liu, Danni ; Bressler, Susan B. ; [et al.]

American Medical Association (AMA) ; 2021

In: JAMA Ophthalmology Vol. 139, No. 12 ( 2021-12-01), p. 1266-

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In: JAMA Ophthalmology, American Medical Association (AMA), Vol. 139, No. 12 ( 2021-12-01), p. 1266-

Type of Medium: Online Resource

ISSN: 2168-6165

URL: Article

DOI: 10.1001/jamaophthalmol.2021.4103

Language: English

Publisher: American Medical Association (AMA)

Publication Date: 2021

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The inter-regional epidemiological study of childhood cancer (IRESCC): Case-control study of children with central nervous system tumours

Birch, Jillian M. ; Hartley, Ann L. ; Teare, M. Dawn ; [et al.]

Informa UK Limited ; 1990

In: British Journal of Neurosurgery Vol. 4, No. 1 ( 1990-01), p. 17-25

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In: British Journal of Neurosurgery, Informa UK Limited, Vol. 4, No. 1 ( 1990-01), p. 17-25

Type of Medium: Online Resource

ISSN: 0268-8697 , 1360-046X

URL: Article

DOI: 10.3109/02688699009000677

Language: English

Publisher: Informa UK Limited

Publication Date: 1990

detail.hit.zdb_id: 1499131-7

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Publisher Correction: Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

Stacey, David ; Chen, Lingyan ; Stanczyk, Paulina J. ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Nature Communications Vol. 13, No. 1 ( 2022-04-06)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2022-04-06)

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-022-29641-6

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2553671-0

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Elucidating mechanisms of genetic cross-disease associations at the PROCR vascular disease locus

Stacey, David ; Chen, Lingyan ; Stanczyk, Paulina J. ; [et al.]

Springer Science and Business Media LLC ; 2022

In: Nature Communications Vol. 13, No. 1 ( 2022-03-09)

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In: Nature Communications, Springer Science and Business Media LLC, Vol. 13, No. 1 ( 2022-03-09)

Abstract: Many individual genetic risk loci have been associated with multiple common human diseases. However, the molecular basis of this pleiotropy often remains unclear. We present an integrative approach to reveal the molecular mechanism underlying the PROCR locus, associated with lower coronary artery disease (CAD) risk but higher venous thromboembolism (VTE) risk. We identify PROCR -p.Ser219Gly as the likely causal variant at the locus and protein C as a causal factor. Using genetic analyses, human recall-by-genotype and in vitro experimentation, we demonstrate that PROCR -219Gly increases plasma levels of (activated) protein C through endothelial protein C receptor (EPCR) ectodomain shedding in endothelial cells, attenuating leukocyte–endothelial cell adhesion and vascular inflammation. We also associate PROCR -219Gly with an increased pro-thrombotic state via coagulation factor VII, a ligand of EPCR. Our study, which links PROCR -219Gly to CAD through anti-inflammatory mechanisms and to VTE through pro-thrombotic mechanisms, provides a framework to reveal the mechanisms underlying similar cross-phenotype associations.

Type of Medium: Online Resource

ISSN: 2041-1723

URL: Article

DOI: 10.1038/s41467-022-28729-3

Language: English

Publisher: Springer Science and Business Media LLC

Publication Date: 2022

detail.hit.zdb_id: 2553671-0

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Inherited variation in immune genes and pathways and glioblastoma risk

Schwartzbaum, Judith A. ; Xiao, Yuanyuan ; Liu, Yanhong ; [et al.]

Oxford University Press (OUP) ; 2010

In: Carcinogenesis Vol. 31, No. 10 ( 2010-10), p. 1770-1777

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In: Carcinogenesis, Oxford University Press (OUP), Vol. 31, No. 10 ( 2010-10), p. 1770-1777

Type of Medium: Online Resource

ISSN: 1460-2180 , 0143-3334

URL: Article

DOI: 10.1093/carcin/bgq152

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 2010

detail.hit.zdb_id: 1474206-8

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IDDM2-VNTR-encoded Susceptibility to Type 1 Diabetes: Dominant Protection and Parental Transmission of Alleles of the Insulin Gene-linked Minisatellite Locus

Bennett, Simon T. ; Wilson, Amanda J. ; Cucca, Francesco ; [et al.]

Elsevier BV ; 1996

In: Journal of Autoimmunity Vol. 9, No. 3 ( 1996-6), p. 415-421

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In: Journal of Autoimmunity, Elsevier BV, Vol. 9, No. 3 ( 1996-6), p. 415-421

Type of Medium: Online Resource

ISSN: 0896-8411

URL: Article

DOI: 10.1006/jaut.1996.0057

RVK:

XA 52099

Language: English

Publisher: Elsevier BV

Publication Date: 1996

detail.hit.zdb_id: 1468989-3

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Reduction of ethnic inequalities in birthweight: a public health paradox

West, Jane ; Lawlor, Debbie A ; Fairley, Lesley ; [et al.]

Elsevier BV ; 2012

In: The Lancet Vol. 380 ( 2012-11), p. S78-

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In: The Lancet, Elsevier BV, Vol. 380 ( 2012-11), p. S78-

Type of Medium: Online Resource

ISSN: 0140-6736

URL: Article

DOI: 10.1016/S0140-6736(13)60434-1

RVK:

XA 10000

Language: English

Publisher: Elsevier BV

Publication Date: 2012

detail.hit.zdb_id: 2067452-1

detail.hit.zdb_id: 3306-6

detail.hit.zdb_id: 1476593-7

SSG: 5,21

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A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium

McKay, James D. ; Truong, Therese ; Gaborieau, Valerie ; [et al.]

Public Library of Science (PLoS) ; 2011

In: PLoS Genetics Vol. 7, No. 3 ( 2011-3-17), p. e1001333-

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In: PLoS Genetics, Public Library of Science (PLoS), Vol. 7, No. 3 ( 2011-3-17), p. e1001333-

Type of Medium: Online Resource

ISSN: 1553-7404

URL: Article

DOI: 10.1371/journal.pgen.1001333

DOI: 10.1371/journal.pgen.1001333.g001

DOI: 10.1371/journal.pgen.1001333.g002

DOI: 10.1371/journal.pgen.1001333.g003

DOI: 10.1371/journal.pgen.1001333.g004

DOI: 10.1371/journal.pgen.1001333.t001

DOI: 10.1371/journal.pgen.1001333.t002

DOI: 10.1371/journal.pgen.1001333.t003

DOI: 10.1371/journal.pgen.1001333.t004

DOI: 10.1371/journal.pgen.1001333.s001

DOI: 10.1371/journal.pgen.1001333.s002

DOI: 10.1371/journal.pgen.1001333.s003

DOI: 10.1371/journal.pgen.1001333.s004

DOI: 10.1371/journal.pgen.1001333.s005

DOI: 10.1371/journal.pgen.1001333.s006

DOI: 10.1371/journal.pgen.1001333.s007

DOI: 10.1371/journal.pgen.1001333.s008

Language: English

Publisher: Public Library of Science (PLoS)

Publication Date: 2011

detail.hit.zdb_id: 2186725-2

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Leukaemia incidence, social class and estuaries: an ecological analysis

Alexander, Freda E. ; Cartwright, Ray A. ; McKinney, Patricia A. ; [et al.]

Oxford University Press (OUP) ; 1990

In: Journal of Public Health Vol. 12, No. 2 ( 1990), p. 109-117

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In: Journal of Public Health, Oxford University Press (OUP), Vol. 12, No. 2 ( 1990), p. 109-117

Type of Medium: Online Resource

ISSN: 1741-3850 , 1741-3842

URL: Article

DOI: 10.1093/oxfordjournals.pubmed.a042527

Language: English

Publisher: Oxford University Press (OUP)

Publication Date: 1990

detail.hit.zdb_id: 1497445-9

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Mobile phone use and risk of glioma in adults: case-control study

Hepworth, Sarah J ; Schoemaker, Minouk J ; Muir, Kenneth R ; [et al.]

BMJ ; 2006

In: BMJ Vol. 332, No. 7546 ( 2006-04-15), p. 883-887

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In: BMJ, BMJ, Vol. 332, No. 7546 ( 2006-04-15), p. 883-887

Type of Medium: Online Resource

ISSN: 0959-8138 , 1468-5833

URL: Article

DOI: 10.1136/bmj.38720.687975.55

Language: English

Publisher: BMJ

Publication Date: 2006

detail.hit.zdb_id: 1479799-9

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