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  • 1
    Online Resource
    Online Resource
    Neuroimaging of full term newborn´s brain with hypoxic-ischemic encephalopathy
    ECO-Vector LLC ; 2016
    In:  Pediatrician (St. Petersburg) Vol. 7, No. 3 ( 2016-09-15), p. 157-161
    Details
    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 7, No. 3 ( 2016-09-15), p. 157-161
    Abstract: Introduction. Hypoxic-ischemic encephalopathy (HIE) in full term newborn is the most frequent courses of neonatal mortality and development of neurology handicap. Magnetic resonance imaging (MRI) is common noninvasive method for detect of post hypoxic brain lesions in newborn. Method of research. We assessed MR-pattern of hypoxic brain injury using Philips Ingenia 1.5 Tl for examination newborn on 14-16 days after delivery. Protocol of MRI scans included axial and coronal plan T1, T2, Flair weighted imaging (WI) and diffusion tensor imaging (DTI) with program Fiber tracking and detected fractional anisotropy (FA). FA was measuring within cortico-spinal tract besides. 3D reconstruction allowed to visualized white matter along the axon direction of cortico-spinal tract. Studies. Four full term newborn (after 37 weeks gestation) have been examined and separated in two groups. First group included newborns with HIE (evidence of fetal distress, low Apgar Scores, low umbilical cord pH ˂ 7.1, necessity for resuscitation and neurological signs, second group consisted term newborn without any medical and problems of health. Results of research. We detected MR-patterns of basal ganglia and thalamus lesions in newborn with HIE (abnormal high signal intensity on T1 and Flair WI). We didn’t detect any abnormal MR scans in healthy newborns (control group). FA within cortico-spinal tracts besides (total and ROI-1) were lower in newborns with HI then in healthy ones. Conclusion. This investigation showed common MR patterns of brain lesions in full term newborns with HIE which included changes of signal intensity T1 and Flair from basal ganglia and thalamus as well as reduction of FA within cortico-spinal tract.
    Type of Medium: Online Resource
    ISSN: 2587-6252 , 2079-7850
    URL: Issue
    URL: Article
    DOI: 10.17816/PED73
    DOI: 10.17816/PED73157-161
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2016
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  • 2
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    Efferent therapy for dichorionic diamniotic twin pregnancy resulting from IVF, complicated by isthmic-cervical insufficiency
    ECO-Vector LLC ; 2022
    In:  Pediatrician (St. Petersburg) Vol. 13, No. 1 ( 2022-05-31), p. 35-42
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    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 13, No. 1 ( 2022-05-31), p. 35-42
    Abstract: Background: Dichorionic diamniotic twin pregnancy resulting from IVF can lead to isthmic-cervical insufficiency with concomitant complications. Against the background of the initial genital chronic infection in a woman there is a threat of septic complications for the mother-fetal couple. The complex pathology is accompanied by an accumulation of toxic substances in the mother-placenta-fetus system that requires pathogenetic treatment measures. Clinical Cases: This paper presents data on the results of efferent therapy in two pregnant women with dichorionic diamniotic twin pregnancy complicated by fetal bladder prolapsing into the cervical canal up to the external pharynx (1 case) and with premature amniotic fluid outflow of the first fetus (2 cases). The patients received preserving therapy at the hospital and then were transferred to the perinatal center with the clinical signs of threatening abortion, endotoxemia, and moderate inflammatory response, which were treated with efferent therapy in the form of medium-volume membrane plasmapheresis combined with photodilution with ultraviolet and laser beams. There were no complications during efferent therapy. In 1 and 2 observations the pregnancies of women in the perinatal center were prolonged by 45 and 34 days with operative delivery at 27 and 31 weeks, respectively. There were no septic complications in women and children. The newborn premature infants after therapeutic and rehabilitative measures had good prospects for a full life. Conclusion: The efferent therapy methods are safe and, in cases of IVF-infant foetuses with complicated isthmic-cervical insufficiency, are a pathogenetic measure; they help to prolong pregnancy and prevent infectious complications in the mother and fetus.
    Type of Medium: Online Resource
    ISSN: 2587-6252 , 2079-7850
    URL: Article
    DOI: 10.17816/PED13135-42
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
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  • 3
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    Online Resource
    Efferent therapy in pregnant women with the threat of very early premature birth with premature effusion of amniotic fluid. Two clinical observations
    ECO-Vector LLC ; 2022
    In:  Pediatrician (St. Petersburg) Vol. 13, No. 4 ( 2022-11-27), p. 93-100
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    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 13, No. 4 ( 2022-11-27), p. 93-100
    Abstract: It is known from the literature that premature amniotic fluid expulsion in 22 weeks 27 weeks 6 days gestation is very dangerous, as it is accompanied by high morbidity and mortality in newborn infants. Clinical observation. This article presents the results of observing two women with premature amniotic fluid expulsion at 22 and 24 weeks gestation, respectively. In the first case, the woman was immediately admitted to the perinatal center; in the second observation, she was admitted after 3.5 weeks of treatment at another institution. In both cases, pregnant women had manifestations of oligo and endotoxemia, a protective inflammatory response in the mother-placental-fetal system (more pronounced in the second observation) against a background of urogenital infection. In the course of complex treatment, the patients underwent detoxification, of efferent therapy in the form of repeated consecutive sessions of plasmapheresis, hemosorption (one operation each), external photomodification of blood with ultraviolet, laser beams with prolongation of pregnancy by 10 and 8 weeks. The deliveries in both cases were operative with live babies with body weight of 1600 g and 1840 g, respectively. In the first case the infant did not need intensive care, was breastfed, in the second observation the newborn received active respiratory support for 9 days, in the dynamics his condition normalized. No septic complications in mothers and fetuses were observed. The concluding efferent therapy in course of therapy were effected by prolongating of pregnancy with of good the results for mothers and them of fetus.
    Type of Medium: Online Resource
    ISSN: 2587-6252 , 2079-7850
    URL: Article
    DOI: 10.17816/PED13493-100
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2022
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  • 4
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    Online Resource
    The Clinical Case Of Symptomatic Epilepsy In Newborn With Neonatal Hypoglycemic Encephalopathy
    ECO-Vector LLC ; 2016
    In:  Pediatrician (St. Petersburg) Vol. 7, No. 4 ( 2016-12-15), p. 147-152
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    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 7, No. 4 ( 2016-12-15), p. 147-152
    Abstract: Symptomatic epilepsy is common disorder in neonatal period. One of the reasons of symptomatic epilepsy can be neonatal hypoglycemia. Hypoglycemia is the commonest metabolic disorder in neonatal period. Neonatal hypoglycemia can cause neonatal hypoglycemic encephalopathy (NHE) with damage of occipital cortex, symptomatic epilepsy in early postnatal period of life and severe neurological impairment in childhood. Early diagnosis of the NHE is possibly by using brain’s MRI and EEG in neonatal period. Presented clinical case of symptomatic epilepsy in newborn with NHE and results of his clinical examination and findings on brain’s MRI, EEG. There has been performance twice EEG recoding in the acute clinical phase of the hypoglycemic encephalopathy with video monitoring. We used multichannel EEG record in the neonatal modification. Once there has been fulfillment MRI (1,5T scanner) in early period of the case disease (after the convulsion discontinuation). We routinely used T1 weighted imaging, T2 weighted imaging, DWI and Flair. We show the correlation functional brain discharge and structural brain damages by MRI in the case of the neonatal hypoglycemic encephalopathy. The EEG recorded epileptiform activity (sharp theta-waves, spices) in central-occipital and temporal regions. We detected the changes MR-signal from central-occipital and temporal brains regions and thinning of occipital cortex with normal cortex architecture
    Type of Medium: Online Resource
    ISSN: 2587-6252 , 2079-7850
    URL: Issue
    URL: Article
    DOI: 10.17816/PED74
    DOI: 10.17816/PED74147-152
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2016
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  • 5
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    Online Resource
    Features of electrophysiological activity in a neonate with severe post-hypoxic brain damage (post-hypoxic cerebral depression)
    ECO-Vector LLC ; 2020
    In:  Pediatrician (St. Petersburg) Vol. 11, No. 6 ( 2020-12-31), p. 13-20
    Details
    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 11, No. 6 ( 2020-12-31), p. 13-20
    Abstract: The article briefly presents the literature data and a description of the clinical dynamic observation of a patient with severe hypoxic brain damage (from the neonatal period to 4 months of life), in the conditions of the neonatal intensive care unit. The article describes the clinical picture, features of paroxysmal states and antiepileptic therapy, dynamics of neuroimaging data, electroencephalographic phenomena recorded in a patient with cerebral depression and structural cerebral injuries. The significance of electroencephalographic examination in the intensive care unit as an informative method for assessing cerebral activity in young children with central nervous system depression syndrome is shown. Disorganization of background activity, indicating structural cerebral damage, long-term persistence of slow-wave activity, detection of epileptic changes in the form of generalized flashes of pointed waves in the theta range, alpha-coma pattern, subsequently replaced by suppression of the background pattern in the patient, are typical electrophysiological disorders recorded in severe hypoxic encephalopathy. In conditions of limited opportunities for visual diagnosis of a patient with impaired consciousness, EEG remains the only method of obtaining information about the functional state of the brain, the data obtained during the study are an important prognostic criterion.
    Type of Medium: Online Resource
    ISSN: 2587-6252 , 2079-7850
    URL: Article
    DOI: 10.17816/PED11613-20
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2020
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  • 6
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    Online Resource
    The results of efferent therapy by woman with HIV infection, with amniotic fluid outflow at 23 weeks with growth retardation syndrome of 2 fetus
    ECO-Vector LLC ; 2020
    In:  Pediatrician (St. Petersburg) Vol. 10, No. 5 ( 2020-01-28), p. 101-104
    Details
    In: Pediatrician (St. Petersburg), ECO-Vector LLC, Vol. 10, No. 5 ( 2020-01-28), p. 101-104
    Abstract: In the article presents data on the management of a 48-year-old patient with HIV infection, urogenital infection with pregnancy, which occurred as a result of IVF, with premature effusion of amniotic fluid at 23 weeks of pregnancy with the syndrome of growth retardation of 2 fetus in monochoric diamniotic twins. After the discharge of the amniotic fluid, the patient was treated for six days in an infectious hospital, then transferred to the perinatal center, where blood tests noted moderatemanifestations of endotoxicosis, increased levels of aminotransferases and an inflammatory reaction of the body. The course of treatment included detoxification methods (plasmapheresis, hemosorption, photomodification of blood with ultraviolet, laser rays), which contributed to the normalization of blood tests, prolongation of pregnancy for another three weeks in the absence of septic complications after operative childbirth in the mother and in newborn girls. At birth, 1 childs weight, body length and Apgar score were 750 g., 29 sm. and3/5points, respectively, in 2 children 590 g., 30 sm. and1/3points, respectively. The children required treatment from resuscitators, at the second stage of nursing, from rehabilitation specialists.
    Type of Medium: Online Resource
    ISSN: 2587-6252 , 2079-7850
    URL: Article
    DOI: 10.17816/PED105101-104
    Language: Unknown
    Publisher: ECO-Vector LLC
    Publication Date: 2020
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